Wednesday September 19, 2018

Your daily cup of coffee can worsen Alzheimer’s symptoms

For the study, the team analysed the effect of caffeine on normal ageing mice and familial Alzheimers models

0
//
48
Coffee can worsen Alzheimer's symptoms. IANS
Republish
Reprint
  • Intake of coffee or caffeine may worsen Alzheimer’s symptoms
  • It may worsen their neuropsychiatric symptoms
  • There can be significant side effects too

Regular intake of coffee or caffeine by patients with Alzheimer’s disease may worsen their neuropsychiatric symptoms, including anxiety, say researchers. While it is well known that memory problems are the hallmarks of Alzheimer’s disease, this dementia is also characterised by neuropsychiatric symptoms, which may be strongly present already in the first stages of the disorder.

Diabetes drug could now treat Alzheimer's disease
Coffee can cause problems to the patients of Alzheimer’s disease. IANS

These are known as Behavioural and Psychological Symptoms of Dementia (BPSD) and include anxiety, apathy, depression, hallucinations, paranoid, sundowning and more. The results indicate that caffeine worsened these symptoms in mice with Alzheimer’s. The researchers also discovered significant effects, especially in relation to neophobia — a fear of everything new — anxiety-related behaviours, and emotional and cognitive flexibility.

“The mice develop Alzheimer’s disease in a very close manner to the human patients with early-onset form of the disease,” said lead author Raquel Baeta-Corral from the Autonomous University of Barcelona in Spain. “They not only exhibit the typical cognitive problems but also a number of Behavioural and Psychological Symptoms of Dementia (BPSD)-like symptoms, so it is a valuable model to address whether the benefits of caffeine will be able to compensate its putative negative effects.”

Also Read: Reducing Alzheimer’s stigma crucial for prevention research

For the study, the team analysed the effect of caffeine on normal ageing mice and familial Alzheimers models. However, coffee has also been suggested as a strategy to prevent dementia, both in patients with Alzheimer’s disease and in normal ageing processes, due to its action in blocking molecules – adenosine receptors – which may cause dysfunctions and diseases in old age.

It can worsen the condition of patients of Alzheimer's. Pixabay
It can worsen the condition of patients of Alzheimer’s. Pixabay

But “our observations of adverse caffeine effects in an Alzheimer’s disease model together with previous clinical observations suggest that an exacerbation of BPSD-like symptoms may partly interfere with the beneficial cognitive effects of caffeine”, the researchers said. IANS

Click here for reuse options!
Copyright 2018 NewsGram

Next Story

Coffee Can Reduce Fatality Rate For People Suffering From Chronic Kidney Disease

For the study, described in the journal Nephrology Dialysis Transplantation, the team involved data from 4,863 people.

0
Coffee beans, chronic kidney disease
Coffee may prolong lifespan for people with kidney disease. VOA

Drinking coffee may help reduce the risk of death for people with chronic kidney disease, suggests a study.

Comparing with people that consumed less caffeine, patients that consumed higher levels of caffeine presented a nearly 25% reduction in the risk of death over a median follow-up of 60 months.

The possible protective effect of caffeine might be related with effects at vascular level as caffeine is known to promote the release of substances, such as nitric oxide, that improve the function of the vessel, the researchers said.

chronic kidney disease
Kidney disease. IANS

“Our study showed a protective effect of caffeine consumption among patients with chronic kidney disease. The reduction in mortality was present even after considering other important factors such as age, gender, race, smoking, other diseases, and diet,” said lead author Miguel Bigotte Vieira from the Centro Hospitalar Lisboa Norte in Portugal.

“These results suggest that advising patients with kidney disease to drink more caffeine may reduce their mortality. This would represent a simple, clinically beneficial, and inexpensive option,” Vieira added.

For the study, described in the journal Nephrology Dialysis Transplantation, the team involved data from 4,863 people.

Also Read: Smelling Coffee May Boost Your Analytical Skills

However, the researchers emphasised that this observational study cannot prove that caffeine reduces the risk of death in patients with chronic kidney disease, but only suggests the possibility of such a protective effect. (IANS)