Wednesday December 11, 2019

New Combo Therapy Found Effective In Kidney Cancer Patients

With this new combination therapy, tumour shrinkage or stabilization was better than that seen in patients taking just one of the two drugs alone, the researchers found

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The study was published in journal The Lancet Oncology. Wikimedia Commons
The study was published in journal The Lancet Oncology. Wikimedia Commons

Combining an anti-angiogenesis agent, which blocks blood vessel formation, with an immunotherapy agent, has shown promising anti-tumour activity in an early phase clinical trial in patients with advanced kidney cancer who had not been previously treated, says a new study.

The findings of the study involving the combination of anti-angiogenesis agent — axitinib (trade name Inlyta) – and the immunotherapy agent — pembrolizumab (trade name Keytruda) – were published in the journal The Lancet Oncology.

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“Our results are unprecedented. The combination doubled the efficacy of the drugs when used alone and the treatment was found to be tolerable,” said Michael Atkins of Georgetown University in Washington, DC, and principal investigator for the study.

The immunotherapy agent, pembrolizumab, is an immune checkpoint inhibitor that blocks a self-defense mechanism used by cancer cells to evade attack and destruction by the body's immune cells. Wikimedia Commons
The immunotherapy agent, pembrolizumab, is an immune checkpoint inhibitor that blocks a self-defence mechanism used by cancer cells to evade attack and destruction by the body’s immune cells. Wikimedia Commons

“Specifically, over 90 percent of patients exhibited tumour shrinkage and the disease was kept under control for a median of over 20 months,” Atkins said.

The investigators started their phase-1 clinical trial of this combination in 2014 and enrolled 52 advanced renal cell carcinoma (the most common form of kidney cancer) patients who had not previously been treated for the disease.

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With this new combination therapy, tumour shrinkage or stabilization was better than that seen in patients taking just one of the two drugs alone, the researchers found.

Patients also had fewer liver abnormalities and less fatigue than those treated with other similar combination therapies, Atkins said.

“We think this combination could present a major advance in the treatment of this disease as well as help define effective combinations of similar drugs for other cancers,” Atkins said. (IANS)

Next Story

Light Alcohol Consumption Might Also Increase Cancer Risk: Study

The researchers found an almost linear association between cancer risk and alcohol consumption

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Alcohol
A light level of Alcohol Consumption at 10-drink-year point, for example, one drink per day for 10 years or two drinks per day for five years would increase cancer risk by five per cent, the findings showed. Pixabay

If you thought one-two drinks a day would not do any harm, think again. Researchers in Japan have found that even light Alcohol consumption might increase the cancer risk.

In the study published in the journal Cancer, the overall cancer risk appeared to be the lowest at zero alcohol consumption. The elevated risk appeared to be explained by alcohol-related cancer risk across relatively common sites, including the colorectum, stomach, breast, prostate and esophagus.

“In Japan, the primary cause of death is cancer,” said one of the researchers Masayoshi Zaitsu from The University of Tokyo. “Given the current burden of overall cancer incidence, we should further encourage promoting public education about alcohol-related cancer risk,” Zaitsu said.

The team examined clinical data on 63,232 patients with cancer and 63,232 controls matched for sex, age, hospital admission date, and admitting hospital. The data was gathered from 33 general hospitals in Japan.

All participants reported their average daily amount of standardised alcohol units and the duration of drinking.

One standardised drink containing 23 grams of ethanol was equivalent to one 180-ml cup of Japanese sake, one 500-ml bottle of beer, one 180-ml glass of wine, or one 60-ml cup of whiskey.

Alcohol
If you thought one-two drinks a day would not do any harm, think again. Researchers in Japan have found that even light Alcohol consumption might increase the cancer risk. Pixabay

The researchers found an almost linear association between cancer risk and alcohol consumption.

A light level of drinking at 10-drink-year point, for example, one drink per day for 10 years or two drinks per day for five years would increase cancer risk by five per cent, the findings showed.

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Those who drank two or fewer drinks a day had an elevated cancer risk regardless of how long they had consumed alcohol. Also, analyses classified by sex, drinking/smoking behaviours and occupational class mostly showed the same patterns. (IANS)