Saturday January 25, 2020

Common Chemotherapy Drug may Lead to Heart Failure: Study

The drug also caused a wasting syndrome in the heart and the spleen

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Cholesterol
Lead, mercury exposure raises cholesterol levels: Study. Pixabay

A chemotherapy drug, widely used for treatment of ovarian, bladder, lung, thyroid and stomach cancers, has the potential to cause heart toxicity that can lead to congestive heart failure, a study led by a professor of Indian origin, has found.

In the study, conducted on mice, doxorubicin induced fibrosis in the heart, increased the programmed cell death called apoptosis and impaired the pumping of the heart.

The drug also caused a wasting syndrome in the heart and the spleen.

The study, led by Ganesh Halade, Assistant Professor at the University of Alabama in the US, found that disruption of the metabolism that controls immune responses in the spleen and heart is vital for heart maintenance, repair and control of inflammation.

For the study, published in the American Journal of Physiology — Heart and Circulatory Physiology, the team used a mouse model to study the effect of doxorubicin on immunometabolism — the study of how metabolism regulates immune cell function.

A dysregulated immunometabolism impairs resolution of inflammation, and chronic, non-resolving inflammation can lead to advanced heart failure.

heart disease
Representational image. (IANS)

Halade’s team found that doxorubicin is also involved in the deleterious response to the spleen.

First, doxorubicin was shown to induce irreversible dysregulation that lowered the levels of enzymes in the left ventricle of the heart, which in turn reduced the levels of bioactive lipids mediators produced by these enzymes, mediators that usually would help resolve inflammation.

In the spleen, doxorubicin also poisoned a special group of marginal zone immune cells called CD169+ macrophages, causing the spleen to diminish in size.

It also caused an imbalance of the cell-signalling molecules called chemokines and cytokines, and this imbalance suggested suppressed defence capacity of spleen-leukocyte immune cells.

Specifically, the researchers found decreased levels of tumour necrosis factor-alpha in the spleen, and decreased levels of the immune-cells reparative marker MRC-1, also known as CD206, in the heart.

Thus, doxorubicin appears to have a splenocardiac impact in this non-cancer model, Halade said. (IANS)

Next Story

Diabetes is an Independent Risk Factor For Heart Failure: Study

According to health expert in India, if poorly controlled, diabetes leads to cardiomyopathy resulting in progressive deterioration of pumping capacity of heart

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Diabetes
The study shows that diabetes is an independent risk factor for the development of heart failure in the community dwelling population. Pixabay

Heart problems are a common development for people with diabetes and now researchers have found that diabetes is an independent risk factor for the development of heart failure in the community dwelling population.

According to health expert in India, if poorly controlled, diabetes leads to cardiomyopathy resulting in progressive deterioration of pumping capacity of heart.

“Diabetes is also a major risk factor for atherosclerosis and this eventually leads to blockage of coronary arteries. This leads to heart attack or myocardial infarction,” Satish Koul, HOD and Director Internal Medicine, Narayana Superspeciality Hospital, Gurugram, told IANS. “Due to myocardial infarction, the heart muscle becomes weak and eventually heart fails as a pump leading to congestive heart failure,” Koul added.

According to the current study, published in the journal Mayo Clinic Proceedings, researchers evaluated the long-term impact of diabetes on the development of heart failure, both with preserved ejection fraction – a measurement of the percentage of blood leaving the heart with each contraction – and reduced ejection fraction. They also looked at mortality in a community population, controlling for hypertension, coronary artery disease and diastolic function.

From an initial group of 2,042 residents of Olmsted County in US, 116 study participants with diabetes were matched 1:2 for age, hypertension, sex, coronary artery disease and diastolic dysfunction to 232 participants without diabetes.

Over the 10-year follow-up period, 21 per cent of participants with diabetes developed heart failure, independent of other causes.

Diabetes
Heart problems are a common development for people with diabetes and now researchers have found that diabetes is an independent risk factor for the development of heart failure in the community dwelling population. Pixabay

In comparison, only 12 per cent of patients without diabetes developed heart failure. Cardiac death, heart attack and stroke were not statistically different in the study between the two groups.

The study shows that diabetes is an independent risk factor for the development of heart failure in the community dwelling population. Furthermore, the outcome data support the concept of a diabetic cardiomyopathy.

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This research extends previous findings and demonstrates that even without a known cardiac structural abnormality and with a normal ejection fraction, diabetic patients are still at increased risk of developing heart failure as compared to their nondiabetic counterparts. (IANS)