Friday April 26, 2019

Common Chemotherapy Drug may Lead to Heart Failure: Study

The drug also caused a wasting syndrome in the heart and the spleen

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Cholesterol
Lead, mercury exposure raises cholesterol levels: Study. Pixabay

A chemotherapy drug, widely used for treatment of ovarian, bladder, lung, thyroid and stomach cancers, has the potential to cause heart toxicity that can lead to congestive heart failure, a study led by a professor of Indian origin, has found.

In the study, conducted on mice, doxorubicin induced fibrosis in the heart, increased the programmed cell death called apoptosis and impaired the pumping of the heart.

The drug also caused a wasting syndrome in the heart and the spleen.

The study, led by Ganesh Halade, Assistant Professor at the University of Alabama in the US, found that disruption of the metabolism that controls immune responses in the spleen and heart is vital for heart maintenance, repair and control of inflammation.

For the study, published in the American Journal of Physiology — Heart and Circulatory Physiology, the team used a mouse model to study the effect of doxorubicin on immunometabolism — the study of how metabolism regulates immune cell function.

A dysregulated immunometabolism impairs resolution of inflammation, and chronic, non-resolving inflammation can lead to advanced heart failure.

heart disease
Representational image. (IANS)

Halade’s team found that doxorubicin is also involved in the deleterious response to the spleen.

First, doxorubicin was shown to induce irreversible dysregulation that lowered the levels of enzymes in the left ventricle of the heart, which in turn reduced the levels of bioactive lipids mediators produced by these enzymes, mediators that usually would help resolve inflammation.

In the spleen, doxorubicin also poisoned a special group of marginal zone immune cells called CD169+ macrophages, causing the spleen to diminish in size.

It also caused an imbalance of the cell-signalling molecules called chemokines and cytokines, and this imbalance suggested suppressed defence capacity of spleen-leukocyte immune cells.

Specifically, the researchers found decreased levels of tumour necrosis factor-alpha in the spleen, and decreased levels of the immune-cells reparative marker MRC-1, also known as CD206, in the heart.

Thus, doxorubicin appears to have a splenocardiac impact in this non-cancer model, Halade said. (IANS)

Next Story

Research Claims, Regular Exercise Can Boost Life Of Breast Cancer Survivors

"The main cause of mortality in women diagnosed with early-stage breast cancer is heart disease," said Kyuwan Lee, doctoral student at the University of Southern California (USC), noting that prescribed exercise is not considered standard care currently.

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The study found that patients who participated in a 16-week exercise programme had a significantly reduced risk of developing cardiovascular disease over their sedentary counterparts. Pixabay

Exercise can likely reduce the risk of heart disease in women with breast cancer, results of a clinical trial has showed.

Breast cancer patients are exposed to a higher risk of cardiovascular complications during and after cancer treatment from chemotherapy and radiation therapy. These can be exacerbated by obesity and sedentary lifestyles.

The study found that patients who participated in a 16-week exercise programme had a significantly reduced risk of developing cardiovascular disease over their sedentary counterparts.

heart
In his next phase, he plans to study prevention of cardiovascular dysfunction in cancer patients undergoing cardio-toxic chemotherapy, which uses drugs whose side effects can cause irreversible damage to the heart muscles. Pixabay

“The main cause of mortality in women diagnosed with early-stage breast cancer is heart disease,” said Kyuwan Lee, doctoral student at the University of Southern California (USC), noting that prescribed exercise is not considered standard care currently.

“We hope that this study shows the importance of exercise in reducing the risk of heart disease to emphasise the need to integrate exercise into clinical practice for cancer patients,” he added.

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Breast cancer patients are exposed to a higher risk of cardiovascular complications during and after cancer treatment from chemotherapy and radiation therapy. These can be exacerbated by obesity and sedentary lifestyles. VOA

For the study, published in the journal Oncology, the team conducted a randomised clinical trial that included 100 sedentary, obese women breast cancer stage I-III survivors.

Also Read: “Countries Had “Set Up” Migrant Caravans That Make Their Way To The U.S.,” President Donald Trump Calls for Ending Aid

The women participated in three weekly supervised one-on-one exercise sessions for 16 weeks: 80-minute sessions of resistance and aerobic exercise for two days and 50 minutes of aerobic exercise on the third day. This intervention meets the exercise guidelines set forth by the American Cancer Society for cancer survivors.

The findings are only the beginning for Lee. In his next phase, he plans to study prevention of cardiovascular dysfunction in cancer patients undergoing cardio-toxic chemotherapy, which uses drugs whose side effects can cause irreversible damage to the heart muscles. (IANS)