Friday November 15, 2019

Common Painkillers Triple Harmful Side Effects in Dementia

Previous studies have recognized that pain is often under-diagnosed and poorly managed in people with dementia, impacting the quality of life

Painkillers may triple side effects risk in dementia patients. Pixabay

Consuming common opioid-based painkillers may triple the risk of side effects including personality changes, confusion and sedation among people with dementia, a study has warned.

It is because people with dementia produce increased amounts of endorphins — body’s natural endogenous opioids — which interacts with brain to reduce our perception of pain, explained researchers from Britain’s University of Exeter.

Previous studies have recognized that pain is often under-diagnosed and poorly managed in people with dementia, impacting the quality of life.

While the opioid-based painkillers ease pain effectively, current prescribing guidance does not consider the fact that people with dementia get effective pain relief from smaller doses than are commonly prescribed, and are particularly sensitive to adverse effects.

“Pain is a symptom that can cause huge distress and it’s important that we can provide relief to people with dementia. Sadly at the moment we’re harming people when we’re trying to ease their pain,” said Clive Ballard from the varsity.

In Alzheimer’s disease, patients start losing memory, Pixabay

For the study, presented at the Alzheimer’s Association International Conference 2018 in Chicago, the team analysed data from 162 people who had advanced dementia and significant depression.

The analysis showed buprenorphine — opioid used to treat acute and chronic pain — tripled the harmful effects on people who received the medication as part of their treatment. These patients were also found to be significantly less active during the day.

The experiment done on mice model showed increased sensitivity to the opioid-based painkiller morphine upon treating arthritis in mice with Alzheimer’s disease.

Also Read: Sound Waves May Help Treat Dementia

The mice with Alzheimer’s responded to a much lower dose to ease pain, and experienced more adverse effects when the dose was increased to a normal level.

“We urgently need more research in this area, and we must get this dosing right. We need to establish the best treatment pathway and examine appropriate dosing for people with dementia,” Ballard explained. (IANS)

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Improved Cardiorespiratory Fitness linked To Lower Dementia Risk

Researchers have linked increased fitness with lower dementia risk

Researchers have found that increased fitness is strongly linked to lower dementia risk. Pixabay

Researchers have found that improvement in cardiorespiratory fitness is strongly linked to lower dementia risk.

“It is important to say that it is never too late to begin exercising. The average participant in our study was around 60 years old at baseline, and improvement in cardiorespiratory fitness was strongly linked to lower dementia risk, said study researcher Atefe Tari from Norwegian University of Science and Technology (NTNU) in Norway.

Those who had poor fitness in the 1980s but improved it within the next decade could expect to live two years longer without dementia,” Tari said.

For the study, published in the journal Lancet Digital Health, between 1984 and 1986, almost 75,000 Norwegians participated in the first wave of the HUNT Survey (HUNT1).

11 years later, HUNT2 was organised, and 33,000 of the same people participated.

More than 30,000 of them answered enough questions to be included in Tari’s analyses.

The researchers calculated cardiorespiratory fitness with a formula previously developed and validated by the researchers, called the Fitness Calculator.

The study links results from the Fitness Calculator to the risk of dementia and dementia-related deaths up to 30 years later.

It’s never too late to start exercising to improve your fitness. Pixabay

To investigate these associations, Tari has used data from two different databases, the Health and Memory Study in Nord-Trondelag and the Norwegian Cause of Death Registry.

Between 1995 and 2011, 920 people with dementia were included in the Health and Memory Study in Nord-Trondelag.

A total of 320 of them had also participated in both HUNT1 and HUNT2 and provided enough information about their own health to be included in the analyses.

It turned out that poor cardiorespiratory fitness in both the 1980s and 1990s was significantly more common in this group than among otherwise comparable HUNT participants who had not been diagnosed with dementia.

In fact, the risk of developing dementia was 40 per cent lower for those who were among the 80 per cent with the best fitness in both the 1980s and 1990s.

Furthermore, it was 48 per cent lower if one had changed from poor to higher fitness levels between the two surveys.

All participants were followed until death or end of follow-up in the summer of 2016.

The researchers found 814 women and men who had died from or with dementia during the period.

This means that dementia was stated as the underlying, immediate or additional cause of death.The risk was lowest for those who had good fitness at both HUNT surveys.

However, also those who had changed from poor to better fitness over the years had a 28 per cent reduced risk.

The study provides evidence that maintaining good fitness is also good for the brain.

Also Read- Taller People Likely To Have An Irregular Heartbeat: Study

“High-intensity exercise improves fitness faster than moderate exercise, and we recommend that everyone exercise with a high heart rate at least two days each week,” Tari said.

“Low fitness is an independent risk factor for dementia and death due to dementia,” the authors concluded. (IANS)