Tuesday April 23, 2019

Common Plastic Chemical May Increase Breast Cancer Risk

Most breast cancers are estrogen receptor positive, and, according to the National Cancer Institute, 55 to 65 per cent of women who inherit a harmful mutation in the BRCA1 gene -- will develop breast cancer

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cancer
Key gene behind breast cancer identified. Pixabay

An endocrine-disrupting chemical commonly found in polycarbonate hard plastics, currency bills and thermal paper receipts may potentially interfere with the body’s hormones to increase the aggressiveness of breast cancer, a new study has showed.

Bisphenol S (BPS), a substitute for the chemical bisphenol A (BPA) in the plastic industry, acts like estrogen in multiplying breast cancer cells.

Most breast cancers are estrogen receptor positive, and, according to the National Cancer Institute, 55 to 65 per cent of women who inherit a harmful mutation in the BRCA1 gene — will develop breast cancer.

“If a woman has a mutated BRAC1 gene and uses products containing BPS, her risk for developing breast cancer may increase further,” said principal investigator, Sumi Dinda, Associate Professor at Oakland University in Michigan.

“Despite hopes for a safer alternative to BPA, studies have shown BPS to exhibit similar estrogen-mimicking behaviour to BPA,” Dinda added.

Cancer
Representational image. Pixabay

The results were presented at ENDO 2017, the Endocrine Society’s 99th annual meeting in Orlando.

For the study, the team used two commercially available breast cancer cell lines obtained from women with estrogen-receptor-positive breast cancer, to expose the cancer cells to varying strengths of BPS or to an inactive substance as a control.

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Compared with the control, BPS heightened the protein expression in estrogen receptor and BRCA1 after 24 hours, as did estrogen.

After a six-day treatment with BPS, the breast cancer cells in both cell lines reportedly increased in number by 12 per cent at the lowest dose (4 micromolars) and by 60 per cent at eight micromolars. (Bollywood Country)

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Chinese Researchers Reveal Mechanism of Chronic Stress Promoting Breast Cancer Development

Qiang noted that patients with breast cancer, ovarian cancer and stomach cancer often have negative emotions, which in turn accelerates the development of their own tumours

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Breast Cancer
Nano technology offers hope for better cancer testing. Pixabay

Chinese researchers have revealed the mechanism of how chronic stress promotes breast cancer development, shedding light on future clinical treatment for cancer.

Cancer patients often suffer negative emotions such as anxiety, despair and fear, which are risk factors facilitating tumour growth as well as promoting cancer progression. However, the specific mechanisms of how chronic stress affects cancer development remains unknown yet.

Researchers from the Dalian Medical University in China found that chronic stress might increase epinephrine levels, which enhances lactate dehydrogenase A (LDHA) and promotes breast cancer stem-like cells, Xinhua reported.

Using a drug screen that targeted LDHA, they found that Vitamin C reversed the chronic stress-induced cancer stem-like phenotype.

The study demonstrates the critical importance of psychological factors in promoting stem-like properties in breast cancer cells and provides a promising therapeutic approach for breast cancer, according to Liu Qiang, lead researcher at the varsity.

Representational image.

“The LDHA-lowering agent Vitamin C can be a potential approach for combating stress-associated breast cancer,” Qiang said, in the paper published in the Journal of Clinical Investigation.

His team has been engaged in the dynamic regulation of cancer stem cells research as well as the mechanism of psychosocial behaviour affecting tumour development.

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Qiang noted that patients with breast cancer, ovarian cancer and stomach cancer often have negative emotions, which in turn accelerates the development of their own tumours.

“It is necessary to monitor their chronic stress comprehensively by taking psychological assessments as well as conducting blood tests which include epinephrine levels,” Qiang said. (IANS)