Sunday March 29, 2020

Natural Compound in Cabbage can Help Fight NAFLD

Indole- a compound found in cruciferous vegetables helps fight fatty liver disease

1
//
cabbage NAFLD
A natural compound found in cruciferous vegetables such as cabbage, kale, cauliflower and Brussels sprouts can help control non-alcoholic fatty liver disease (NAFLD). Pixabay

A natural compound found in cruciferous vegetables such as cabbage, kale, cauliflower and Brussels sprouts can help control non-alcoholic fatty liver disease (NAFLD), new research has found.

The research, published in the journal Hepatology, suggests that this natural compound called indole may lead to new treatments or preventive measures for fatty liver disease.

“Based on this research, we believe healthy foods with high capacity for indole production are essential for preventing NAFLD and are beneficial for improving the health of those with it,” said principal investigator for the study Chaodong Wu, Faculty Fellow at Texas A&M AgriLife Research in the US.

“This is another example where altering the diet can help prevent or treat disease and improve the well-being of the individual,” Wu said. NAFLD occurs when the liver becomes “marbled” with fat, sometimes due to unhealthy nutrition, such as excessive intake of saturated fats.

Cauliflower NAFLD
Healthy foods such as cauliflower, cabbage and kale with high capacity for indole production are essential for preventing NAFLD. Pixabay

If not properly addressed, this condition can lead to life-threatening liver disease, including cirrhosis or liver cancer. Many diverse factors contribute to NAFLD.

The present study examined the effect of indole concentrations on people, animal models and individual cells to help determine indole’s effect on liver inflammation and its potential benefits to people with NAFLD.

For the study, the researchers investigated the effects of indole on 137 Chinese individuals with fatty livers.

The research team discovered people with a higher body mass index tended to have lower levels of indole in their blood. This result will likely extend to other ethnicities, said research collaborator Qifu Li, a physician at Chongqing Medical University in China.

To further determine the impact of indole, the research team used animal models fed a low-fat diet as a control and high-fat diet to simulate the effects of NAFLD. The research team also studied how indole affected individual cells.

Also Read- How the Youth is Helping Politics Grow in India

In addition to reducing the amount of fat in liver cells, indole also acts on cells in the intestine, which send out molecular signals that dampen inflammation, said Shannon Glaser, Professor of Texas A&M Health Science Center.

“Foods with a high capacity of indole production or medicines that mimic its effects may be new therapies for treatment of NAFLD,” Wu said, adding prevention is another important aspect to consider. (IANS)

  • Alexandra Middleton

    This is not new news. Naturopaths have been using Indole (I3C) for years for liver detox.

Next Story

Lockdown in India May be Ineffective to Stop COVID-19: Report

India may see 25 crore COVID-19 cases in next 3 months: Report

0
India lockdown
The lockdown in India is not productive and could cause serious economic damage, increase hunger and reduce the population resilience for handling the infection peak. Pixabay

In what could spell real trouble for the country in the next three months, a new report from prestigious Johns Hopkins University and the Centre for Disease Dynamics, Economics & Policy (CDDEP) has predicted that 21-day lockdown may be ineffective to stop the COVID-19 peak arriving in April-May-June — infecting over 12 crore Indians in an optimistic (low) scenario.

In a High scenario (trajectory with current lockdowns but insufficient physical distancing or compliance), the total number of cases (asymptomatic, hospitalized and symptomatic) can even touch a massive figure of 25 crore.

In the most likely (Medium) scenario with moderate to full compliance but no change in virulence or temperature/humidity sensitivity, the numbers of total cases can swell up to 18 crore.

India lockdown
A new report from prestigious Johns Hopkins University and the Centre for Disease Dynamics, Economics & Policy (CDDEP) has predicted that 21-day lockdown in India may be ineffective to stop the COVID-19. Pixabay

The optimistic (low) scenario constitutes decreased virulence and temperature/humidity sensitivity.

To reach these numbers, Johns Hopkins and CDDEP — a public health research organisation — used IndiaSIM, a well-validated agent-based model of the Indian population which has been published widely over many years and has been used for government decision-making.

According to the report, hospitalised cases can reach up to 25 lakh people in the High scenario, 17-18 lakh people in Medium scenario and 13 lakh people in Low scenario.

“Ventilator demand will be 1 million. Current availability in India is estimated to be between 30,000 and 50,000 ventilators,” said the joint report.

“Mortality in healthcare workers could further increase deaths in the general population. Healthcare workers need personal protective equipment (masks and gowns) to protect themselves. Without them they get sick further straining the capacity of the healthcare system to respond,” the report warned.

The number of coronavirus cases climbed to 649 in India on Thursday and the death toll hit 13, with one death reported each from Gujarat, Tamil Nadu and Madhya Pradesh, according to the Health Ministry.

But March is the month when peak is yet to even begin, according to the report.

According to the report, delays in testing are seriously reducing the ability of the population to protect itself.

“This is the most important way in which we can contain the epidemic. An increase in the official number of detected cases in the short term could encourage the population to take distancing more seriously and will reduce panic compared to a big spike later,” the findings showed.

“Border closures at this stage have little to no impact and add further economic disruption and panic. While international transmission was important in the first stage, domestic transmission is now far more relevant,” it warned.

India lockdown
The number of coronavirus cases climbed to 649 in India on Thursday and the death toll hit 13, with one death reported each from Gujarat, Tamil Nadu and Madhya Pradesh, according to the Health Ministry. Pixabay

A national lockdown, said the report, is not productive and could cause serious economic damage, increase hunger and reduce the population resilience for handling the infection peak.

“Some states may see transmission increase only after another 2 weeks and lockdowns should be optimized for when they could maximize the effect on the epidemic but minimize economic damage,” said Johns Hopkins-CDDEP report.

State-level lockdowns in the most affected states could change the trajectory of the epidemic and should commence immediately. Any delay allows for more secondary cases to emerge.

Lockdowns should be guided by testing and serological survey data and should be planned on a rolling basis, the report mentioned, adding that preparedness for case load should be the highest priority at this time.

“Temperature and humidity increases should help us in reducing case load. Although the evidence is limited, it is plausible,” the report mentioned.

Evidence from China indicates that higher temperature and humidity are likely to lower the transmission rates but it is unclear “how this will translate to the India context”.

India “should be prepared for multiple peaks in the model and should be prepared for more cases and deaths later in the year”.

In India, initial infections likely first arrived in early February, according to the report.

Also Read- “Taking Low-Dose Aspirin May Not Reduce Risk of Dementia”, Says Study

People who will show symptoms next week are already infected and incubating the virus. Some of these will transmit before they are symptomatic. A large percentage of cases are mild, but for older individuals, the mortality rate is strikingly higher.

“Children are less likely to be infected and also less likely to be hospitalized than adults. Illness is less likely to be severe in children than in adults,” the report noted. (IANS)