Tuesday March 19, 2019

Compound Found in Grape Skin Can Protect Against Lung Cancer: Research

The resveratrol concentration obtained in the lungs after nasal administration of the formulation was 22 times higher than when taken orally

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grapes, improvement of teeth
Consumption of grapes can lead to having healthier teeth. Pixabay

Researchers have found that a molecule — resveratrol — found in grape skin, seeds and red wine can protect against lung cancer.

Lung cancer is the deadliest form of the disease in the world and 80 per cent of deaths are related to smoking. In addition to tobacco control, effective chemo-prevention strategies are therefore needed.

In experiments in mice, the researchers from the University of Geneva (UNIGE) prevented lung cancer induced by a carcinogen found in cigarette smoke by using resveratrol.

Lung cancer
This formulation is applicable to humans, the researchers noted.

“We observed a 45 per cent decrease in tumour load per mouse in the treated mice. They developed fewer tumours and of smaller size than untreated mice,” said Muriel Cuendet, associate professor at the varsity.

The team conducted their 26-week study on four groups of mice. The first one — the control — received neither carcinogen nor resveratrol treatment. The second received only the carcinogen. The third received both the carcinogen and the treatment, whereas the fourth received only the treatment.

When comparing the two groups that were not exposed to carcinogen, 63 per cent of the mice treated did not develop cancer, compared to only 12.5 per cent of the untreated mice.

“Resveratrol could, therefore, play a preventive role against lung cancer,” Cuendet added.

This formulation is applicable to humans, the researchers noted.

Lung cancer
Tobacco use is one of the main risk factors for a number of chronic diseases, including cancer, lung diseases and cardiovascular diseases, Pixabay

However, when ingested, resveratrol did not prevent lung cancer as it is metabolised and eliminated within minutes. It does not have time to reach the lungs.

Also Read: Wine Tied to Healthier Arteries for Some Diabetics

Conversely, when the molecule was administered through the nasal route, it as found to be much effective and allows the compound to reach the lungs.

The resveratrol concentration obtained in the lungs after nasal administration of the formulation was 22 times higher than when taken orally, the researchers said. (IANS)

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Amazing Fact! Your Genes Determine Your Quality of Sleep

"Our study suggests that many of the genes important for sleep in animal models may also influence sleep in humans and opens the door to better understanding of the function and regulation of sleep," Dashti added.

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genes
This was comparable to other well-recognised factors that influenced sleep duration. Pixabay

Experiencing problems like insomnia or hypersomnia could be genetic, say researchers who identified 76 new gene regions associated with the time a person sleeps.

It is well known that regularly getting adequate sleep — 7 to 8 hours per night — is important for health, and both insufficient sleep — 6 or fewer hours — and excessive sleep — 9 hours or more — have been linked to significant health problems.

Family studies have suggested that 10 to 40 per cent of variation in sleep duration may be inherited, and previous genetic studies have associated variants in two gene regions with the sleep duration.

sleep
“Our study suggests that many of the genes important for sleep in animal models may also influence sleep in humans and opens the door to better understanding of the function and regulation of sleep,” Dashti added. Pixabay

The study from the Massachusetts General Hospital (MGH) in Boston, US, analysed genetic data from more than 446,000 participants, who self-reported the amount of sleep they typically received.

The study identified 78 gene regions — including the two previously identified — as associated with sleep duration.

While carrying a single gene variant influenced the average amount of sleep by only a minute, participants carrying the largest number of duration-increasing variants reported an average of 22 more minutes of sleep, compared with those with the fewest.

This was comparable to other well-recognised factors that influenced sleep duration.

 

sleep
Family studies have suggested that 10 to 40 per cent of variation in sleep duration may be inherited, and previous genetic studies have associated variants in two gene regions with the sleep duration. Pixabay

“While we spend about a third of our life asleep, we have little knowledge of the specific genes and pathways that regulate the amount of sleep people get,” said Hassan Saeed Dashti from MGH.

“Our study suggests that many of the genes important for sleep in animal models may also influence sleep in humans and opens the door to better understanding of the function and regulation of sleep,” Dashti added.

The study, published in Nature Communications journal, also found shared genetic links between both short and long sleep duration.

Also Read: SpaceX Crew Dragon Capsule Undocks from International Space Station

It also found factors such as higher levels of body fat, depression symptoms and fewer years of schooling, implying negative effects from both too little and too much sleep.

While short sleep duration was genetically linked with insomnia and smoking, long sleep duration was linked with ailments such as schizophrenia, Type-2 diabetes and coronary artery disease. (IANS)