Saturday May 25, 2019

Compound Found in Grape Skin Can Protect Against Lung Cancer: Research

The resveratrol concentration obtained in the lungs after nasal administration of the formulation was 22 times higher than when taken orally

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grapes, improvement of teeth
Consumption of grapes can lead to having healthier teeth. Pixabay

Researchers have found that a molecule — resveratrol — found in grape skin, seeds and red wine can protect against lung cancer.

Lung cancer is the deadliest form of the disease in the world and 80 per cent of deaths are related to smoking. In addition to tobacco control, effective chemo-prevention strategies are therefore needed.

In experiments in mice, the researchers from the University of Geneva (UNIGE) prevented lung cancer induced by a carcinogen found in cigarette smoke by using resveratrol.

Lung cancer
This formulation is applicable to humans, the researchers noted.

“We observed a 45 per cent decrease in tumour load per mouse in the treated mice. They developed fewer tumours and of smaller size than untreated mice,” said Muriel Cuendet, associate professor at the varsity.

The team conducted their 26-week study on four groups of mice. The first one — the control — received neither carcinogen nor resveratrol treatment. The second received only the carcinogen. The third received both the carcinogen and the treatment, whereas the fourth received only the treatment.

When comparing the two groups that were not exposed to carcinogen, 63 per cent of the mice treated did not develop cancer, compared to only 12.5 per cent of the untreated mice.

“Resveratrol could, therefore, play a preventive role against lung cancer,” Cuendet added.

This formulation is applicable to humans, the researchers noted.

Lung cancer
Tobacco use is one of the main risk factors for a number of chronic diseases, including cancer, lung diseases and cardiovascular diseases, Pixabay

However, when ingested, resveratrol did not prevent lung cancer as it is metabolised and eliminated within minutes. It does not have time to reach the lungs.

Also Read: Wine Tied to Healthier Arteries for Some Diabetics

Conversely, when the molecule was administered through the nasal route, it as found to be much effective and allows the compound to reach the lungs.

The resveratrol concentration obtained in the lungs after nasal administration of the formulation was 22 times higher than when taken orally, the researchers said. (IANS)

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East African Countries Set to Ban Skin-Lightening Products Containing Hydroquinone

If bans are not backed by enforcement, they will have little effect on the use of the high demand skin-lightening products, despite the risk to health

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skin-lightening products
FILE - Aranmolate Ayobami, plastic surgeon at Grandville Medical and Laser clinic in Lagos, holds a tube of Skinlite a skin lightening product used at his clinic, on July 17, 2018, in Lagos, Nigeria. VOA

East African countries are set to ban skin-lightening products that contain hydroquinone, a medical agent linked to health problems when used in high concentrations. The East African Legislative Assembly last week passed a resolution calling for a region-wide ban on the manufacturing and importation of products containing hydroquinone.

At a beauty parlor in Arusha, 52-year-old Rose Mselle has been using skin-bleaching products since she was a teenager. She says women like her want to be beautiful. “And in the process of looking for beauty, or for our skin color to shine, we use things that we shouldn’t,” she added.

At a nearby market, 32-year-old clothing vendor Janet Jonijosefu used skin-lightening products that contain hydroquinone, a medical agent used to treat dark spots, for years. She stopped after her skin became fragile.

She said the beauty products containing hydroquinone badly affected her skin. She started developing patches on her face. She went to the doctor and was advised to stop using products containing hydroquinone and instead use aloe vera.

skin-lightening products
FILE – A shop sells skin-lightening products in Accra, Ghana, on July 3, 2018. VOA

Skin-lightening products often use high concentrations of hydroquinone, which can cause skin problems or become toxic when mixed with other bleaching chemicals.

Ghana, Ivory Coast, Kenya, Nigeria, Rwanda, and South Africa ban or regulate the agent in cosmetics. Tanzania bars imports. The East African Legislative Assembly last week passed a resolution on a region-wide ban of hydroquinone’s manufacture and importation.

Suzan Nakawuki, a member of the regional assembly from Uganda, noted that hydroquinone is not only used by women but also men. “We have seen men bleaching seriously even more than women,” she said. “But it’s becoming a problem. If we don’t regulate it, it is going to become very problematic.”

When used medically, hydroquinone can be an effective treatment for skin discoloration. Some East African lawmakers spoke out against a blanket ban. Aden Abdikadir, a lawmaker from Kenya, said he is concerned a blanket ban will cause “serious trade disruption” for cosmetics.

skin-lightening products
If bans are not backed by enforcement, they will have little effect on the use of the high demand skin-lightening products, despite the risk to health. Wikimedia Commons

If signed by heads of state, the ban becomes law in all six East African Community states, which include Burundi, Kenya, Rwanda, South Sudan, Tanzania and Uganda.

Critics point out bans on hydroquinone have failed to stop smuggled products from being sold openly. Cosmetics labeled as having hydroquinone are on display at shops in Arusha.

If bans are not backed by enforcement, they will have little effect on the use of the high demand skin-lightening products, despite the risk to health. (VOA)