Thursday December 12, 2019

Compound Present in Red Wine can Treat Depression and Anxiety

"Resveratrol may be an effective alternative to drugs for treating patients suffering from depression and anxiety disorders," said Ying Xu

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Red Wine, Depression, Anxiety
The plant compound resveratrol displays anti-stress effects by blocking the expression of an enzyme which controls stress in the brain. Pixabay

In a good news for wine lovers, researchers have found a compound present in red wine which can treat depression and anxiety.

The plant compound resveratrol displays anti-stress effects by blocking the expression of an enzyme which controls stress in the brain.

“Resveratrol may be an effective alternative to drugs for treating patients suffering from depression and anxiety disorders,” said Ying Xu, Associate Professor, University at Buffalo in the US.

The findings, published in the journal Neuropharmacolog, shed light onto how neurological processes are impacted by resveratrol — a compound having numerous health benefits and found in the skin and seeds of grapes and berries.

Red Wine, Depression, Anxiety
In a good news for wine lovers, researchers have found a compound present in red wine which can treat depression and anxiety. Pixabay

While research has identified resveratrol to have antidepressant effects, the compound’s relationship to phosphodiesterase 4 (PDE4), an enzyme influenced by the stress hormone corticosterone, was unknown.

Corticosterone regulates the body’s response to stress. Too much stress, however, can lead to excessive amounts of the hormone circulating in the brain and, ultimately, to depression or other mental disorders.

The research also reveals that PDE4, induced by excessive amounts of corticosterone, causes depression- and anxiety-like behaviour.

The enzyme lowers cyclic adenosine monophosphate — a messenger molecule that signals physiological changes such as cell division, change, migration and death — in the body, leading to physical alterations in the brain.

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Resveratrol displayed neuroprotective effects against corticosterone by inhibiting the expression of PDE4. The research lays the groundwork for the use of the compound in novel antidepressants.

According to the researchers, although red wine contains resveratrol, consumption of alcohol has various health risks, including addiction. (IANS)

Next Story

Deep Sleep Can Reduce Higher Anxiety Levels

A Study strongly suggests that insufficient sleep amplifies levels of anxiety and, conversely, that deep sleep helps reduce such stress

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Deep Sleep had restored the brain's prefrontal mechanism that regulates our emotions, lowering emotional and physiological reactivity and preventing the escalation of anxiety. Pixabay

Researchers have found that the type of Sleep most apt to calm and reset the anxious brain is deep sleep, also known as non-rapid eye movement (NREM) slow-wave sleep, a state in which neural oscillations become highly synchronised, and heart rates and blood pressure drops.

A sleepless night can trigger up to a 30 per cent rise in anxiety levels, researchers from the University of California said.

“We have identified a new function of deep sleep, one that decreases anxiety overnight by reorganising connections in the brain,” said study senior author Professor Matthew Walker.

“Deep sleep seems to be a natural anxiolytic (anxiety inhibitor), so long as we get it each and every night,” Walker added.

“Our study strongly suggests that insufficient sleep amplifies levels of anxiety and, conversely, that deep sleep helps reduce such stress,” said study lead author Eti Ben Simon.

In a series of experiments using functional MRI and polysomnography, among other measures, researchers scanned the brains of 18 young adults as they viewed emotionally stirring video clips after a full night of sleep, and again after a sleepless night.

Anxiety levels were measured following each session via a questionnaire known as the state-trait anxiety inventory.

After a night of no sleep, brain scans showed a shutdown of the medial prefrontal cortex, which normally helps keep our anxiety in check, while the brain’s deeper emotional centres were overactive.

Deep
Researchers have found that the type of Sleep most apt to calm and reset the anxious brain is Deep sleep, also known as non-rapid eye movement (NREM) slow-wave sleep, a state in which neural oscillations become highly synchronised, and heart rates and blood pressure drops. Pixabay

After a full night of sleep, during which participants’ brain waves were measured via electrodes placed on their heads, the results showed their anxiety levels declined significantly, especially for those who experienced more slow-wave NREM sleep.

“Deep sleep had restored the brain’s prefrontal mechanism that regulates our emotions, lowering emotional and physiological reactivity and preventing the escalation of anxiety,” Simon said.

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Beyond gauging the sleep-anxiety connection in the 18 original study participants, the researchers replicated the results in a study of another 30 participants.

Across all the participants, the results again showed that those who got more nighttime deep sleep experienced the lowest levels of anxiety the next day.  (IANS)