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Researchers have developed a computational model which is effective in detecting and identifying genetic mutations in breast tumours. Unsplash

Researchers have developed a computational model which is effective in detecting and identifying genetic mutations in breast tumours.

The study included results from over 3,200 patients with breast cancer.


The researchers used RNA sequencing, a sensitive, precise tool which has very gradually started to be applied clinically, although not yet for breast cancer.

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The study, published in the journal EMBO Molecular Medicine, used breast tumours for analysis from the unique Swedish SCAN-B project.

“We hope that SCAN-B RNA sequencing will be in clinical use as early as next year, mainly to help in the identification of which breast tumours are high-risk and which are low-risk,” said study researcher Lao Saal from Lund University in Sweden.

“The aim is for the patient to know, already a week after surgery to remove the tumour, which personalised treatment is best suited to the individual”,

Saal added.

When the Lund team analysed the genetic mutations in the breast tumours of the patients in the study, they found that almost 87 per cent had at least one mutation for which potential drugs already exist.


The Lund team found that almost 87% breast tumours had at least one mutation for which potential drugs already exist. Unsplash

Then they followed the patterns of mutations in the tumours and related them to patient outcomes.

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“We observed that 34 per cent of them had a mutation in a specific gene, PIK3CA, and that in general these patients had a good prognosis,”

the study researchers wrote.

“In 3 per cent of the patients we found mutations in another gene, ERBB2, which was associated with a worse prognosis,” they added.

The results of the study add another dimension to how RNA sequencing can be used as a potential future ‘clinical tool’. (IANS)


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Rihanna was summoned from her seat to accept the honour, with the Prime Minister.

Singer Rihanna was honoured by Prime Minister Mia Mottley at an event which marked Barbados's new status as a republic, which was attended by Prince Charles. Addressing the pop star by her real name, the PM said: "Robyn Rihanna Fenty tomorrow morning shall have conferred upon her the order of national hero of Barbados."

Rihanna was then summoned from her seat to accept the honor, with the Prime Minister managing to rouse a laugh from the singer when she referenced her 2012 hit 'Diamonds', reports femalefirst.co.uk. She added: "On behalf of a grateful nation, but an even prouder people, we therefore present to you, the designee, for the national hero of Barbados." "And to accept on behalf of a grateful nation - you can come my dear - ambassador Robyn Rihanna Fenty, may you continue to shine like a diamond and bring honor to your nation." Rihanna, who was born in the St Michael parish of Barbados, found fame in 2005 after being spotted by a record producer and has since gone on to become one of the most successful female artists of all time with sales of over 250 million and recently reached billionaire status through her Fenty beauty brand.

The Prime Minister continued in her speech: "Commanding the imagination of the world through the pursuit of excellence, her creativity, her discipline, and above all else, her extraordinary commitment to the land of her birth. "Having satisfied that, Ambassador Robyn Rihanna Fenty has given service to Barbados which has been exemplified by visionary and pioneering leadership, extraordinary achievement and the attaining of the highest excellence to the Government of Barbados." It comes after a historic move for Barbados, which has become a republic after almost 400 years and welcomes its first president, Sandra Mason, after removing Queen Elizabeth as head of state. (IANS/ MBI)


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