Friday December 6, 2019

Here’s Why Excess Consumption of Protein is Harmful for your Body

Protein promotes cancer and suppresses anti-tumour immunity

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Protein food
Researchers have found that excess protein can fuel cancer development. Pixabay

Researchers have found that a protein involved in immune response to microbes also can fuel cancer development and suppress the response to the disease.

Working in mouse models of lung cancer, the research team found TANK-binding kinase 1 (TBK1) and its adaptor proteiTBK-binding protein 1 (TBKBP1) contribute to tumorigenesis when they are activated by growth factors rather than by innate immune mechanisms.

“Our work also provides the first evidence that TBK1 functions in cancer cells to mediate immunosuppression, suggesting that targeting TBK1 will both inhibit tumour growth and promote antitumor immunity,” said study senior author Shao-Cong Sun from University of Texas in the US.

Recent research indicated that TBK1, which normally mediates induction of type 1 interferon in response to viruses or bacteria, also promotes the survival and reproduction of KRAS-dependent cancer cells.

Eggs protein
Consuming protein-rich food such as eggs can suppress anti-tumour immunity. Pixabay

For the findings published in the journal Nature Cell Biology, the research team set out to identify TBK1’s impact on cancer cells and its role in cancer development in vivo.

In a series of experiments, the researchers showed that TBK1 and TBKBP1 form a growth factor signaling axis that activates mTORC1 to promote tumour development.

The pathway consists of TBKBP1 recruiting TBK1 to protein kinase C-theta (PKC), through a scaffold protein called CARD10, enabling PKC to activate TBK1.

To test the protein’s therapeutic potential, the research team treated mice with KRAS-driven lung cancer with amlexanox, a drug approved by the Food and Drug Administration as a paste to treat certain oral ulcers.

The drug was recently identified as a TBK1 inhibitor. Mice injected with amlexanox had a steep reduction in the number and size of lung tumors.

KRAS-driven cancer is resistant to immune response, but the researchers found amlexanox sensitised tumours to blockade of the CTLA-4 checkpoint on immune T cells.

Knocking down TBK1 in the KRAS-driven mouse model increased the frequency of effector CD4 helper T cells and CD8 cell-killing T cells in the lungs of the mice.

Lentils protein
Channa daal and all other lentils are rich in protein. Pixabay

A similar experiment in another mouse model also reduced the frequency of immune-suppressing myeloid-derived suppressor cells.

Additional experiments implicated TBK1 in promotion of glycolysis – a sugar-burning metabolic process that also suppresses the immune system – and the increased presence of PD-L1, a protein on tumour cells that turns off attacking T cells by connecting with the PD-1 protein on their cell surface.

Treatment with amlexanox and anti-CTLA-4 immunotherapy stimulated immune response and reduced tumour size and frequency in the mouse models.

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“We’re continuing to examine the signaling function of TBK1 in different types of immune cells using animal models and to assess the therapeutic potential of TBK1 using preclinical cancer models,” Sun said. (IANS)

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Parents With Single Child More Likely to Tackle an Obese Kid: Study

Researchers found mothers of singleton children were more likely to be obese themselves

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Researchers have found that only Child, who researchers refer to as 'singleton,' have less healthy family eating practices, beverage choices, and total Healthy Eating Index 2010 score, coming in lower on three out of the 12 areas measured. Pixabay

Parents with only Child are more likely to tackle an obese kid as children without siblings may be at a higher risk of gaining weight than those who have brothers and sisters, say researchers.

This is because families with multiple children tend to make more healthy eating decisions than families with a single child, the study added.

The study, published in the Journal of Nutrition Education and Behavior, found that this kind of obesity could be seven times more common among youngsters.

“Healthier eating behaviours and patterns may result from household-level changes rather than peer exposure, as peer exposure is also present in away-from-home care,” said study lead author Chelsea L. Kracht from the University of Oklahoma in the US.

According to the researchers, data was self-reported in daily food logs kept by mothers over the course of three days — two weekdays and one weekend day. Teachers kept logs by proxy for any food children ate while at school.

Mothers also completed the Family Nutrition and Physical Activity questionnaire to evaluate typical family eating behaviour like food and beverage choice.

Child
Parents with only Child are more likely to tackle an obese kid as children without siblings may be at a higher risk of gaining weight than those who have brothers and sisters, say researchers. Pixabay

Researchers have found that only-children, who researchers refer to as ‘singletons,’ had less healthy family eating practices, beverage choices, and total Healthy Eating Index 2010 score, coming in lower on three out of the 12 areas measured.

They also had significantly lower total scores across weekdays, weekends, and on average, indicating there are both individual and collective differences in eating patterns between the groups.

Researchers found mothers of singleton children were more likely to be obese themselves. Moreover, maternal BMI had a much stronger connection to child BMI percentile and waist circumference percentile than singleton status.

Maternal BMI did not significantly contribute to overall eating patterns but did contribute to empty calories.

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Families with multiple children tend to make more healthy eating decisions than families with a single Child, the study added. Pixabay

The research also found that time spent in away-from-home care like school and daycare was not connected to children’s eating patterns.

“Nutrition professionals must consider the influence of family and siblings to provide appropriate and tailored nutrition education for families of young children,” said Kracht.

ALSO READ: Escalating Consequences of Climate Change Hit Countries Globally

“Efforts to help all children and families establish healthy eating habits and practices must be encouraged,” Kracht added. (IANS)