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Biological E has completed Phase III studies on over 3,000 participants across 33 research locations in India.

Corbevax: protein sub-unit vaccine

Corbevax, developed by Biological E in Hyderabad, is a protein subunit vaccine, which means it uses fragments of the virus rather than the full virus to trigger an immune response. The subunit vaccination in this case is a harmless S protein. When the immune system recognises a protein, antibodies are created in order to combat infection if it occurs.


The antigenic parts of the virus were generated by Texas Children's Hospital Centre for Vaccine Development and were in-licensed from BCM Ventures (Baylor College of Medicine). In January, Biological E plans to begin producing 75 million doses per month, with the goal of reaching 100 million doses per month by February.

Biological E has completed Phase III studies on over 3,000 participants across 33 research locations in India.Neutralizing Delta strain antibody titres, according to the paper, "indicates a vaccination effectiveness of >80% for the prevention of symptomatic diseases based on published studies."

It's also run Phase III active comparator clinical studies to see if this vaccination is better than Covishield. "When measured for Neutralizing Antibody (nAb) Geometric Mean Titers (GMT) against the Ancestral-Wuhan strain and the globally dominant Delta variant in the pivotal Phase III study conducted with an endpoint of immunogenic superiority, CORBEVAX demonstrated superior immune response in comparison to COVISHIELD vaccine when measured for Neutralizing Antibody (nAb) Geometric Mean Titers (GMT) against the Ancestral-Wuhan strain and the globally dominant Delta variant," according


Molnupiravir: antiviral medication, taken orally

THE MEDICINE: Molnupiravir, originally developed in conjunction by US companies Ridgeback Biotherapeutics and Merck to treat influenza, has been repurposed to treat Covid patients. It's licenced for the treatment of adult Covid-19 patients "with high risk of disease progression." By inserting errors into the virus's genetic code, it prevents it from multiplying. Molnupiravir comes in 200 mg pills, and in India, 800 mg twice a day for five days is suggested.

EFFICACY: Molnupiravir was cleared by the UK's medicines authority on December 4 after it was deemed to be "safe and effective." Because it may impair bone and cartilage formation, the US (clearance on December 23) did not allow it to be used for more than five days in a row or in patients less than 18 years old.

Covid vaccine Novavax has used a chemical that helps to strengthen the immune system.Scroll.in/wikipedia

Also read: S.Korea approves emergency authorization

In India, it is recommended that adult Covid patients with an oxygen level of > 93 percent and a high risk of disease development be treated, and that the medicine be offered exclusively by prescription at retail.


Novavax: vaccination made out of recombinant nanoparticles

THE VACCINE: Novavax is a protein subunit vaccine made by the Serum Institute of India (SII), however it employs recombinant nanoparticle technology. Novavax, a company located in the United States, created it. The spike protein is generated in insect cells and then extracted and assembled into virus-like nanoparticles. Novavax has used a chemical that helps to strengthen the immune system.

According to SII, the vaccine has been tested in two Phase 3 trials: one in the UK, which showed 96.4 percent efficacy against the original virus strain, 86.3 percent against Alpha, and 89.7 percent overall efficacy; and the PREVENT-19 trial in the US and Mexico, which showed 100 percent protection against moderate and severe disease and 90.4 percent overall efficacy.

On November 17, the Philippines FDA granted SII permission to market the vaccine in the country. On December 20, the immunisation was added to the WHO's Emergency Use List.

Novavax revealed on December 2 that patients who received a third (6-month booster) dose of this vaccination after a booster dose at Day 189 had "robust anti-Spike IgG responses." "When compared to the maximal response reported following the main vaccine series, neutralisation titers increased 4.3-fold overall," it claimed. The business said that it will start investigating whether antibodies from previously vaccinated people can neutralise the virus.


(keywords: Covid-19, oral pill, vaccination, SII, booster)


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