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Biological E has completed Phase III studies on over 3,000 participants across 33 research locations in India.

Corbevax: protein sub-unit vaccine

Corbevax, developed by Biological E in Hyderabad, is a protein subunit vaccine, which means it uses fragments of the virus rather than the full virus to trigger an immune response. The subunit vaccination in this case is a harmless S protein. When the immune system recognises a protein, antibodies are created in order to combat infection if it occurs.

The antigenic parts of the virus were generated by Texas Children's Hospital Centre for Vaccine Development and were in-licensed from BCM Ventures (Baylor College of Medicine). In January, Biological E plans to begin producing 75 million doses per month, with the goal of reaching 100 million doses per month by February.

Biological E has completed Phase III studies on over 3,000 participants across 33 research locations in India.Neutralizing Delta strain antibody titres, according to the paper, "indicates a vaccination effectiveness of >80% for the prevention of symptomatic diseases based on published studies."

It's also run Phase III active comparator clinical studies to see if this vaccination is better than Covishield. "When measured for Neutralizing Antibody (nAb) Geometric Mean Titers (GMT) against the Ancestral-Wuhan strain and the globally dominant Delta variant in the pivotal Phase III study conducted with an endpoint of immunogenic superiority, CORBEVAX demonstrated superior immune response in comparison to COVISHIELD vaccine when measured for Neutralizing Antibody (nAb) Geometric Mean Titers (GMT) against the Ancestral-Wuhan strain and the globally dominant Delta variant," according

Molnupiravir: antiviral medication, taken orally

THE MEDICINE: Molnupiravir, originally developed in conjunction by US companies Ridgeback Biotherapeutics and Merck to treat influenza, has been repurposed to treat Covid patients. It's licenced for the treatment of adult Covid-19 patients "with high risk of disease progression." By inserting errors into the virus's genetic code, it prevents it from multiplying. Molnupiravir comes in 200 mg pills, and in India, 800 mg twice a day for five days is suggested.

EFFICACY: Molnupiravir was cleared by the UK's medicines authority on December 4 after it was deemed to be "safe and effective." Because it may impair bone and cartilage formation, the US (clearance on December 23) did not allow it to be used for more than five days in a row or in patients less than 18 years old.

Covid vaccine Novavax has used a chemical that helps to strengthen the immune

Also read: S.Korea approves emergency authorization

In India, it is recommended that adult Covid patients with an oxygen level of > 93 percent and a high risk of disease development be treated, and that the medicine be offered exclusively by prescription at retail.

Novavax: vaccination made out of recombinant nanoparticles

THE VACCINE: Novavax is a protein subunit vaccine made by the Serum Institute of India (SII), however it employs recombinant nanoparticle technology. Novavax, a company located in the United States, created it. The spike protein is generated in insect cells and then extracted and assembled into virus-like nanoparticles. Novavax has used a chemical that helps to strengthen the immune system.

According to SII, the vaccine has been tested in two Phase 3 trials: one in the UK, which showed 96.4 percent efficacy against the original virus strain, 86.3 percent against Alpha, and 89.7 percent overall efficacy; and the PREVENT-19 trial in the US and Mexico, which showed 100 percent protection against moderate and severe disease and 90.4 percent overall efficacy.

On November 17, the Philippines FDA granted SII permission to market the vaccine in the country. On December 20, the immunisation was added to the WHO's Emergency Use List.

Novavax revealed on December 2 that patients who received a third (6-month booster) dose of this vaccination after a booster dose at Day 189 had "robust anti-Spike IgG responses." "When compared to the maximal response reported following the main vaccine series, neutralisation titers increased 4.3-fold overall," it claimed. The business said that it will start investigating whether antibodies from previously vaccinated people can neutralise the virus.

(keywords: Covid-19, oral pill, vaccination, SII, booster)



K'taka Hijab Row Triggers Debate.

By M.K. Ashoka

The issue of wearing a hijab (head covering worn in public by Muslim women) to the colleges along with the uniform has sparked a debate in Karnataka over religious practices impacting the education system in the state. The matter has also snowballed into a controversy on whether the hijab could be considered as part of the uniform. The ruling BJP is deliberating on whether to take a call on allowing hijab as part of the uniform of college students. State Education Minister B.C. Nagesh, while opposing the wearing of hijab to classrooms, has said that a decision would be taken on the issue soon by the government.

The experts as well as students are divided over the issue. Those who are in favour state that the dress code in classrooms should not indicate faith or religion as it creates barriers between students as well as teachers. Those who support the wearing of hijab say that hijab should be treated as a scarf. Hijab is black in colour and it can't be a religious symbol as Islam is identified with the green colour. The hijab should be treated as a symbol of chastity, they maintain.

The denial of permission to six girls in the Government Girls' Pre University College in the communally sensitive district of Udupi in the state has created a controversy. Nagesh dubbed it as a political move and questioned whether centres of learning should become religious centres. Meanwhile, the girl students have decided to continue their protest until they are allowed to attend classes wearing hijab.

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Police have come under sustained attack around the country. | Unsplash

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Also Read : Police in Spain distribute masks to commuters

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The most common allergen in India are milk, egg and peanuts.

By Dr Nidhi Gupta

Motherhood comes with its own mixed bag of emotions; we want to save our child from every little peril that comes their way, including allergies. The most common allergen in India are milk, egg and peanuts. According to the IAP survey, 11.4 per cent children under the age of 14 years suffer from some form of allergies and they usually peak around the month of May.

The symptoms of allergy range from runny nose, sneezing, coughing, rashes, watery and red eyes to swollen tongue and breathing difficulties. A child experiences serious discomfort and it leaves the parents hopeless at times. Allergies develop slowly over time; parents need to have patience and commitment towards managing them. However, there are certain ways in which we, as parents, can contribute in prevention and possible alleviation of the problems.

* Do Not Stress

Staying stress-free and calm is very important during this time. Creating panic will only add to the misery. Once we know about the symptoms, our mandate must be to keep a first-aid antiallergic kit at home. We can make this kit with the help of our paediatrician.

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