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The nasal spray contains a chemical that can inactivate the coronavirus spike protein, which was produced by researchers at the University of Helsinki in Finland. TriSb92, the novel molecule, has been demonstrated to protect against coronavirus infection for at least eight hours in cell cultures and animal trials, even in circumstances of high exposure risk.
In contrast to vaccination protection, TriSb92's action begins very immediately after it is given.
"In animal models, nasally delivered TriSb92 provided protection against infection in an exposure condition when all unprotected mice were affected," stated Anna Makela, a varsity postdoctoral researcher. The findings have not yet been subjected to peer review.
The TriSb92 molecule is based on a completely new technology technique for targeting biological agents that was created in Finland. The solution was used in the study to stop the spike protein on the surface of the SARS-CoV-2 virus from working.
"Targeting the TriSb92 molecule's inhibitory impact on a region of the coronavirus spike protein that is common to all variations," Makela stated.
Image showing how TriSb92 works.YLE/wikipedia
TriSb92 was able to stop the spread of SARS, the virus that attacked us in the early 2000s, in model viral tests.
"In other words, we may reasonably expect future varieties of SARS-CoV-2, and possibly even totally new coronaviruses, to be sensitive to it," Makela added.
The chemical might be used as a type of biological defence against coronavirus infection that is sprayed on the mucous membranes in the future if it is given as a nasal spray."
Also read: How Covid infection affects your liver?
These sorts of infection-prevention chemicals, or antiviral medications for that matter, cannot replace vaccinations in safeguarding the population against the coronavirus sickness," stated university Professor Kalle Saksela.
However, there is a pressing need for new ways to improve the protection offered by vaccinations. "TriSb92 may be beneficial to patients whose vaccination protection is limited due to a variety of factors. It may also help fully vaccinated persons when given before any setting with a high chance of exposure, depending on the epidemic condition "Saksela said. (IANS/PR)
(Keywords: TriSb92, SARS-CoV-2 virus, nasal spray, coronavirus infection, infection-prevention chemicals, antiviral medications)
New Delhi, Jan 12 (IANS): Leading Western experts believed a lab leak in Wuhan was the 'likely' origin of Covid but were silenced because it could cause harm to Chinese scientists, bombshell emails show, the Daily Mail reported. Sir Jeremy Farrar, who publicly denounced the theory as a 'conspiracy', had admitted in a private email in February 2020 that a 'likely explanation' was that the virus was man-made.
The then-UK government advisor said at the time he was '70:30 or 60:40' in favour of an accidental release versus natural origin, the report said. In the email, sent to American health chiefs Anthony Fauci and Francis Collins, Farrar said it was possible that Covid had been evolved from a Sars-like virus in the lab. He went on that this seemingly benign process may have 'accidentally created a virus primed for rapid transmission between humans'.
Also Read : Tissue culture lab at Kanha Shantivanam
But the British scientist was shut down by his counterparts in the US who warned that further debate about the origin of the virus could damage 'international harmony', the report said. He was told by other scientists with links to virus manipulation research that it could cause 'unnecessary harm to science in general and science in China in particular'.
Mike Farzan, the Harvard researcher who first discovered how the original Sars virus binds to human cells. National Cancer Institute / Unsplash
Farrar claimed in his emails that other respected scientists also believed the virus could not have emerged naturally. The names included professor Mike Farzan, the Harvard researcher who first discovered how the original Sars virus binds to human cells, the report said. Despite his concerns, Farrar went on to sign letters in The Lancet a fortnight later denouncing anyone who believed in the lab leak theory as bigoted. (IANS/SP)
(Keywords : western, experts, China, laboratory, leak, COVID, virus, accidental, debate, manipulation, research, science, scientists, Sars, transmission, human, American, British.)
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According to a new study done by academics at the University of Tennessee, up to 11% of Covid-19 users had liver co-morbidities.
During the course of the disease, 14% to 53% of people had higher levels of liver enzymes such alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Increased levels of liver enzymes may indicate that a person's liver has been damaged, at least briefly. Covid has resulted in significant liver damage in some cases. Swelling of the liver, jaundice (yellow discoloration of the eyes and urine), and failure of liver function tests are the most prevalent.
Also read: Covid to become a seasonal pandemic
Dr Shubham Vatsya, Consultant - Gastroenterology at Fortis Escorts Hospital in Faridabad, told IANS that nonspecific inflammation caused by Covid is fairly frequent in the liver and appears in numerous forms. "Covid infection can cause a wide spectrum of liver damage, some of which are entirely asymptomatic. It might result in jaundice or even liver failure "Dr. Jatin Agrawal, Associate Consultant, Gastroenterology, Max Hospital, Saket, added to the discussion.
Covid has resulted in significant liver damage in some cases. Swelling of the liver, jaundice (yellow discoloration of the eyes and urine), and failure of liver function tests are the most prevalent.
Covid infection can cause a wide spectrum of liver damage, some of which are entirely asymptomatic.Nature/wikipedia
Dr Shubham Vatsya, Consultant - Gastroenterology at Fortis Escorts Hospital in Faridabad, told IANS that nonspecific inflammation caused by Covid is fairly frequent in the liver and appears in numerous forms.
"Covid infection can cause a wide spectrum of liver damage, some of which are entirely asymptomatic. It might result in jaundice or even liver failure "Dr. Jatin Agrawal, Associate Consultant, Gastroenterology, Max Hospital, Saket, added to the discussion. While immunizations can lessen the severity of Covid infection, research on whether they can prevent liver impairment is "extremely sparse," according to him.
Also read: How masks prevent risks of Covid infection
Viruses can alter the liver's function in a number of ways, according to Agrawal. "One is due to the virus's direct effect on hepatocytes (liver's main functional cells) and cholangiocytes (bile duct epithelial cells) via the ACE2 receptor, while the other is due to medication interactions. The liver is affected by covid storm and sepsis "He expressed himself.
"Proper nutrition, intake of a high protein diet, which includes eggs, green leafy vegetables, paneer, it would help you maintain your immunity and it is also a very essential metabolite for the liver," Vatsya explained.
(Keywords: Covid Infection, University of Tennessee, Liver, immunizations, hepatocytes, cholangiocytes, ACE2 receptor, high protein diet, green leafy vegetables, paneer)
Masks, social distancing, proper hygiene and ventilation can help reduce the transmission of Covid-19 in public places, but even with these measures, scientists have detected airborne SARS-CoV-2 in indoor settings. Now, researchers from Yale University have developed a passive air sampler clip that can help assess personal exposure to SARS-CoV-2, which could be especially helpful for workers in high-risk settings, such as restaurants or health care facilities.
The researchers developed a wearable passive air sampler, known as the Fresh Air Clip, that continually adsorbs virus-laden aerosols on a polydimethylsiloxane (PDMS) surface. Described in ACS' Environmental Science & Technology Letters, the clip is a small, lightweight, inexpensive and wearable device that doesn't require a power source.
Covid-19 is primarily transmitted through the inhalation of virus-laden aerosols and respiratory droplets that infected individuals expel by coughing, sneezing, speaking or breathing.
The researchers developed a wearable passive air sampler, known as the Fresh Air ClipPhoto by Yale University
Previously active air sampling devices helped detect airborne SARS-CoV-2 in indoor settings; however, these monitors are typically large, expensive, non-portable and require electricity. The team tested the air sampler in a rotating drum in which they generated aerosols containing a surrogate virus, a bacteriophage with similar properties to SARS-CoV-2.
They detected the virus on the PDMS sampler using the polymerase chain reaction (PCR), showing that the device could be used to reliably estimate airborne virus concentrations. Then, the researchers distributed Fresh Air Clips to 62 volunteers, who wore the monitors for five days.
PCR analysis of the clips detected SARS-CoV-2 RNA in five of the clips: Four were worn by restaurant servers and one by a homeless shelter staff person. The highest viral loads (more than 100 RNA copies per clip) were detected in two badges from restaurant servers.
Although the Fresh Air Clip has not yet been commercialised, these results indicate that it could serve as a semiquantitative screening tool for assessing personal exposure to SARS-CoV-2, as well as help identify high-risk areas for indoor exposure, the researchers said.
(Keywords: SARS-CoV-2, Infection, Coronavirus, Delta, Omicron, Masks, Social Distancing, Ventilation, Health, Medicine)