Wednesday June 26, 2019

Daily aspirin use may cut digestive cancer risk | Health News

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Aspirin

Hong Kong, October’31: Individuals who regularly use pain reliever aspirin are likely to experience a significant reduction in digestive cancer risk, finds a study involving over 600,000 people.

The findings showed that patients who were prescribed aspirin daily showed a 47 per cent reduction in liver and oesophageal cancer incidence.

 Gastric cancer reduced by 38 per cent, pancreatic cancer by 34 per cent while colorectal cancer by 24 per cent, it said.

Digestive cancers account for almost a quarter of cancer cases in Europe.

Colorectal, gastric and pancreatic cancer are within the top five cancer killers throughout the continent, with digestive cancers representing 30.1 per cent of cancer deaths.

“The findings demonstrate that the long-term use of aspirin can reduce the risk of developing many major cancers,” said lead researcher Kelvin Tsoi, Professor at the Chinese University of Hong Kong.

“What should be noted is the significance of the results for cancers within the digestive tract, where the reductions in cancer incidence were all very substantial, especially for liver and oesophageal cancer,” Tsoi added.

The results were presented at the 25th United European Gastroenterology Week in Barcelona.

Moreover, the effect of long-term use of aspirin was also seen in significant reduction in leukaemia, lung and prostate cancers and some breast, bladder, kidney and multiple myeloma cancers.

For the study, the team compared patients who were prescribed aspirin over a long period (for at least six months, average duration of aspirin prescribed was 7.7 years) with non-aspirin users.

Whilst the use of aspirin is debated within the medical community, a recent study also found that patients who stopped taking aspirin were 37 per cent more likely to have an adverse cardiovascular event, such as a heart attack or stroke, than those who continued with their prescription, the researchers noted.(IANS)

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Taking Daily Aspirin Pill Without Heart Disease Increases the Risk of Brain Bleeding

For the current study, researchers examined data from 13 clinical trials testing the effects of aspirin against a placebo or no treatment in more than 134,000 adults

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aspirin, heart disease
Aspirin pills are arranged on a counter in New York, Aug. 23, 2018. New studies find most people won't benefit from taking daily low-dose aspirin to prevent a first heart attack or stroke. VOA

For people without heart disease, taking a daily aspirin to prevent heart attacks and strokes may increase the risk of severe brain bleeding to the point where it outweighs any potential benefit, a research review suggests.

U.S. doctors have long advised adults who haven’t had a heart attack or stroke but are at high risk for these events to take a daily aspirin pill, an approach known as primary prevention. Even though there’s clear evidence aspirin works for this purpose, many physicians and patients have been reluctant to follow the recommendations because of the risk of rare but potentially lethal internal bleeding.

For the current study, researchers examined data from 13 clinical trials testing the effects of aspirin against a placebo or no treatment in more than 134,000 adults. The risk of intracranial hemorrhage, or brain bleeds, was rare: taking aspirin was associated with two additional cases of this type of internal bleeding for every 1,000 people, the study found.

But the bleeding risk was still 37 percent higher for people taking aspirin than for people who didn’t take this drug. “Intracranial hemorrhage is a special concern because it is strongly associated with a high risk of death and poorer health over a lifetime,” said study co-author Dr. Meng Lee of Chang Gung University College of Medicine in Taiwan.

heart disease, aspirin
“We have long known that aspirin can precipitate bleeding, most commonly in the gastrointestinal tract, but most devastatingly in the brain,” said Dr. Samuel Wann. Pixabay

“These findings suggest caution regarding using low-dose in individuals without symptomatic cardiovascular disease,” Lee said by email.

Post-cardiac event use

For people who have already had a heart attack or stroke, the benefit of low-dose aspirin to prevent another major cardiac event is well established, researchers note in JAMA Neurology. But the value of aspirin is less clear for healthier people, for whom bleeding risks may outweigh any benefit, the study team writes.

Already, guidelines on aspirin for primary prevention of heart disease in the U.S., Europe and Australia have incorporated a need to balance the potential benefits against the risk of bleeding. For elderly people, who have a greater risk of bleeding than younger adults, the risks may be too great to recommend aspirin.

For adults ages 50 to 59 considering aspirin to prevent heart attacks and strokes, for example, the U.S Preventive Services Task Force (USPSTF) recommends the pill only for people who have at least a 10 percent risk of having a heart attack or stroke over the next decade and who don’t have a higher-than-average risk of bleeding. (The American College of Cardiology provides an online risk calculator.

Heart disease, aspirin
For people without heart disease, taking a daily aspirin to prevent heart attacks and strokes may increase the risk of severe brain bleeding. Pixabay

One limitation

One limitation of the analysis is that the smaller clinical trials examined a variety of aspirin doses up to 100 milligrams daily. The analysis also only focused on brain bleeds, and not on other types of internal bleeding associated with aspirin.

“We have long known that aspirin can precipitate bleeding, most commonly in the gastrointestinal tract, but most devastatingly in the brain,” said Dr. Samuel Wann, a cardiologist at Ascension Healthcare in Milwaukee, Wisconsin, who wasn’t involved in the study.

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Despite the benefits for preventing heart attacks, the consensus on aspirin has changed over time, particularly for people without heart disease or hardening and narrowing of thearteries (atherosclerosis).

“We have previously recommended aspirin to prevent platelets from sticking to the inside of an individual’s arteries, but the benefit, while real, turns out to be small compared to the rare but devastating incidence of brain hemorrhage,” Wann said by email. “We no longer recommend routine use of aspirin in individuals who have no demonstrable cardiovascular disease or atherosclerosis.” (VOA)