Contrary to earlier findings, German researchers have concluded that there is no higher risk of death from heart disease in breast cancer patients following radiotherapy or chemotherapy.
In a largest cohort study evaluating data from almost 350,000 patients from the US cancer registries, the team found that the risk is no higher than it is among the average population. Good risk management in the hospitals, as well as control screenings at short intervals, seem to make up for elevated risks, said researchers from the German Cancer Research Centre (DKFZ) in Heidelberg.
“At first, we were also surprised by this result. But we assume that our study paints a more realistic picture of the actual situation of treatment than clinical trials,” said Janick Weberpals, the study’s initial author, in a paper published in the European Heart Journal.
Breast cancer is the second-most frequent cancer worldwide and the most common cancer in women. However, improved screening measures and more effective treatment methods have considerably lowered the risk of succumbing to the disease.
“However, a number of clinical trials have suggested that both chemotherapy and radiotherapy are associated with the risk of suffering heart disease as a consequence of treatment,” said Hermann Brenner from DKFZ.
Brenner’s team analysed cases of women who were diagnosed with breast cancer in the years 2000-2011 and subsequently received treatment by radiotherapy or chemotherapy. The scientists found that the long-term risk of mortality from heart disease is not higher following breast cancer treatment than in the average female population.
“We consider the result of our study to be very positive for the treatment of breast cancer,” said Brenner. “It is particularly good news for the large number of affected patients that if they are in good medical care and have survived breast cancer, they do not need to be more worried about deadly heart diseases than women at the same age without breast cancer,” the researchers added. IANS
Breast cancer in men is rarely seen. It shares many similarities with cancer of the breast in women but there are some important differences too.
Male breast cancer represents between 0.5 and 1 per cent of all breast cancers diagnosed each year. Higher rates of male cancer in central and eastern Africa may be related to higher liver infectious diseases that lead to hypoestrogenism.
Dr Kumardeep Dutta Choudhury, Senior Consultant & Head of Department, Dept of Medical Oncology (IOSPL), Fortis Hospital, Noida, shares the facts you need to know about it.
Risk factors associated with breast cancer in men:
Genetics and family history
Family history of cancer in a first-degree relative is associated with an increased risk of breast cancer among men. Approximately 15 to 20 per cent of men with breast cancer have a family history of the disease compared with only 7 per cent of the general male population.
The risk is higher with inherited BRCA2 rather than BRCA1 mutations. Other genes which have been associated with an increased risk of breast cancer in men are PTEN tumor suppressor gene (Cowden syndrome), tumor protein p53 (TP53; Li-Fraumeni syndrome), partner and localizer of BRCA2 (PALB2), and mismatch repair genes (Lynch syndrome).
Alterations of the estrogen to androgen ratio
Excessive estrogen stimulation may be due to hormonal therapies (e.g., estrogen-containing compounds or testosterone), hepatic dysfunction, obesity, marijuana use, thyroid disease, or an inherited condition, such as Klinefelter syndrome may increase risk of male breast cancer.
Primary testicular conditions
Testicular conditions may increase risk of breast cancer in men include orchitis, undescended testes (cryptorchidism), and testicular injury.
Male breast cancer has been diagnosed at a more advanced stage than female breast cancer, due to a lack of awareness. They generally present with a painless, firm mass that is usually subareolar, with nipple involvement in 40 to 50 percent of cases. The left breast is involved slightly more often than the right, and less than 1 percent of cases are bilateral. There may be associated skin changes, including nipple retraction, ulceration, or fixation of the mass to the skin or underlying tissues. Axillary nodes are typically palpable in advanced cases.
Most histologic subtypes of that cancer seen in women are also present in men, men with breast cancer are rarely diagnosed with lobular carcinomas is due to lack of acini and lobules in the normal male breast, although these can be induced in the context of estrogenic stimulation.
Approach to treatment in men is same as that for women. However, role of breast conserving surgery is limited because of small volume of breast tissue. In hormone receptor-positive disease, we give adjuvant tamoxifen rather than an aromatase inhibitor (AI), because of insufficient evidence to support AI monotherapy for men. If there are contraindications to tamoxifen (e.g., hypercoagulable state), an AI with GnRHa may be administered. AIs do not reduce testicular production of estrogens, that’s why GnRHa is administered concurrently with AI. They are treated with mastectomy, radiotherapy, chemotherapy and hormone therapy.
Limited data suggest these patients are at an increased risk of a contralateral breast cancer, but absolute risk is low. They are also at risk for secondary malignancies and 12.5 percent may develop a second primary cancer. The most common types were gastrointestinal, pancreas, non-melanoma skin, and prostate cancer.
Ten-year disease-specific survival rates for histologically negative nodes – 77 and 84 per cent, one to three positive nodes – 50 and 44 per cent and four or more histologically positive nodes – 24 and 14 per cent. (IANS)