Monday, September 21, 2020
Home Lead Story Decoded: How Cancer Cells Cripple Immune System

Decoded: How Cancer Cells Cripple Immune System

Anti-PD1 therapy blocks interaction between PD-1 -- a protein on the surface of T-cells -- and PD-L1, PD-1's counterpart molecule on tumour cells, thus reinvigorating T-cells and allowing them to unleash killing power on the tumour

Researchers have found that cancer cells send out biological “drones” to fight the immune system and survive.

The study showed that cancer cells release “drones” — small vesicles called exosomes circulating in the blood and armed with proteins called PD-L1 that cause T-cells to tire before they have a chance to reach the tumour.

The research offers a paradigm-shifting picture of how cancers take a systemic approach to suppressing the immune system.

In addition, it also points to a new way to predict which cancer patients will respond to anti-PD1 therapy that disrupts immune suppression to fight tumours.

“Immunotherapies are life-saving for many patients with metastatic melanoma, but about 70 per cent of these patients don’t respond,” said Guo Wei, Professor at the University of Pennsylvania.

“These treatments are costly and have toxic side effects so it would be very helpful to know which patients are going to respond,” Wei added.

Cancer
Representational image. Pixabay

Anti-PD1 therapy blocks interaction between PD-1 — a protein on the surface of T-cells — and PD-L1, PD-1’s counterpart molecule on tumour cells, thus reinvigorating T-cells and allowing them to unleash killing power on the tumour.

In the study, published in the journal Nature, the team found that exosomes from human melanoma cells also carried PD-L1 on their surface. Exosomal PD-L1 can directly bind to and inhibit T-cell functions.

Identification of the exosomal PD-L1 secreted by tumour cells provides a major update to the immune checkpoint mechanism, and offers novel insight into tumour immune evasion.

Also Read: SPF30 Sunscreens may Delay Onset of Skin Cancer

According to the researchers, exosomes are tiny lipid-encapsulated vesicles with a diameter less than 1/100 of a red blood cell.

Since a single tumour cell is able to secrete many copies of exosomes, the interaction between the PD-L1 exosomes and T-cells provides a systemic and highly effective means to suppress anti-tumour immunity in the whole body. This may explain why cancer patients might have weakened immune system, they noted. (IANS)

STAY CONNECTED

19,147FansLike
362FollowersFollow
1,774FollowersFollow

Most Popular

Varun Sharma: I’ve Always Been Intrigued With the Process of Wildlife Filmmaking

Actor Varun Sharma says he has always been fascinated and intrigued with the whole process of wildlife filmmaking. Follow NewsGram on LinkedIn to know what's...

Designer Dolly J’s Latest Collection Celebrates Body Confidence

Designer Dolly J's latest couture collection celebrates body confidence and ethnicity. The designer launched her collection 'Gulenaar' on Day 3 of the first-ever digital...

Sachin Khedekar: I Believe No Great Actor Can Rise Above a Bad Script

Actor Sachin Khedekar believes a good script is truly important for an actor to showcase his acting skills. "The script plays one of the most...

Audio Capsules: Making Education Easier for Visually Challenged Students

Audio capsules recorded by a faculty member of a degree college in Uttar Pradesh have proved to be a boon for visually challenged students....

Pandemic To Increase Child Labour, Trafficking & Slavery: Satyarthi

The COVID-19 pandemic will result in "most definite and substantial increase" in child labour, child trafficking and slavery across the world, warned Nobel Laureate...

Wooden Puppets Will Enact Ramlila In Varanasi This Year

The world famous Ramlila in Varanasi will not be held this year due to the pandemic but the tradition will not be broken either. Wooden...

Guidelines For Disposal Of Cigarette Butts Within 3 Months To Be Layed Down

The National Organisation for Tobacco Eradication on Sunday welcomed the direction of the National Green Tribunal (NGT) to the Central Pollution Control Board (CPCB)...

Actress Malaika Arora Feels Blessed To Overcome Covid-19

Actress Malaika Arora says she feels blessed to have overcome Covid-19 with minimum pain. Malaika, who tested positive earlier this month, took to Instagram to...

Recent Comments

Donate to NewsGram to support quality journalism.
x