Tuesday March 26, 2019

Deficiency of Zinc May up Hypertension

Understanding the specific mechanisms by which zinc deficiency contributes to blood pressure dysregulation may have an important effect on the treatment of hypertension in chronic disease settings, the team noted

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'3-in-1' hypertension pill offers better success: Study
'3-in-1' hypertension pill offers better success: Study. Flickr

Lower-than-normal levels of zinc — a nutrient that helps the immune system fight off invading bacteria and viruses — may contribute to hypertension, finds a new study on mice.

The study, from the Wright State University in the US, demonstrated that the way in which the kidneys either excrete sodium into the urine or reabsorb it into the body — specifically through a pathway called the sodium chloride cotransporter (NCC) — also plays a role in controlling high blood pressure.

Zinc deficiency is common in people with illnesses such as Type-2 diabetes and chronic kidney disease.

It also showed that less sodium in the urine typically corresponds with higher blood pressure.

Zinc may help regulate proteins that in turn regulate the NCC, the study suggested.

For the study, researchers compared male mice with zinc deficiency to healthy controls with normal zinc levels.

Representational image. Pixabay

The results, published in the American Journal of Physiology — Renal Physiology, showed that zinc-deficient mice developed high blood pressure and a corresponding decrease in urinary sodium excretion.

However, the control group did not experience the same changes.

A small group of the zinc-deficient mice were fed a zinc-rich diet partway. Once the animals’ zinc reached adequate levels, blood pressure began to drop and urinary sodium levels increased.

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“These significant findings demonstrate that enhanced renal (sodium) re-absorption plays a critical role in (zinc-deficiency)-induced hypertension,” said Clintoria R. Williams, a researcher from the varsity.

Understanding the specific mechanisms by which zinc deficiency contributes to blood pressure dysregulation may have an important effect on the treatment of hypertension in chronic disease settings, the team noted. (IANS)

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Get Success with These 3-in-1 Hypertension Pills: Study

The findings could impact guidelines on treating hypertension globally.

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'3-in-1' hypertension pill offers better success: Study
'3-in-1' hypertension pill offers better success: Study. Flickr

With over a billion people struggling to control their high blood pressure globally, an Australian study suggests a “three-in-one” pill for better results for hypertension.

The trial involved three drugs, each at half dose, in a single pill for early treatment. It met with success in 70 per cent of the cases in a targeted group, the George Institute for Global Health (GIGH) said on Wednesday.

In conventional medication, patients are treated with one drug at a very low dose, which is increased over time with additional drugs added and increased in dosage to try to reach targets.

Hypertension, 3in 1 pill Flickr
With over a billion people struggling to control their high blood pressure,try a three-in-one” pill for better results. Flickr

However, the Australian-led trials showed that low-dose of the “three-in-one” pill helped almost three-fourth patients to lower their blood pressure compared to just around half receiving normal care, Xinhua news agency reported.

“Our results could help millions reduce their risk of heart attack or stroke,” said Ruth Webster of GIGH said. The study was published in JAMA, a journal of the American Medical Association.

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The findings could impact guidelines on treating hypertension globally, said the institute. (IANS)