Friday January 24, 2020

Deficiency of Zinc May up Hypertension

Understanding the specific mechanisms by which zinc deficiency contributes to blood pressure dysregulation may have an important effect on the treatment of hypertension in chronic disease settings, the team noted

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'3-in-1' hypertension pill offers better success: Study
'3-in-1' hypertension pill offers better success: Study. Flickr

Lower-than-normal levels of zinc — a nutrient that helps the immune system fight off invading bacteria and viruses — may contribute to hypertension, finds a new study on mice.

The study, from the Wright State University in the US, demonstrated that the way in which the kidneys either excrete sodium into the urine or reabsorb it into the body — specifically through a pathway called the sodium chloride cotransporter (NCC) — also plays a role in controlling high blood pressure.

Zinc deficiency is common in people with illnesses such as Type-2 diabetes and chronic kidney disease.

It also showed that less sodium in the urine typically corresponds with higher blood pressure.

Zinc may help regulate proteins that in turn regulate the NCC, the study suggested.

For the study, researchers compared male mice with zinc deficiency to healthy controls with normal zinc levels.

Representational image. Pixabay

The results, published in the American Journal of Physiology — Renal Physiology, showed that zinc-deficient mice developed high blood pressure and a corresponding decrease in urinary sodium excretion.

However, the control group did not experience the same changes.

A small group of the zinc-deficient mice were fed a zinc-rich diet partway. Once the animals’ zinc reached adequate levels, blood pressure began to drop and urinary sodium levels increased.

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“These significant findings demonstrate that enhanced renal (sodium) re-absorption plays a critical role in (zinc-deficiency)-induced hypertension,” said Clintoria R. Williams, a researcher from the varsity.

Understanding the specific mechanisms by which zinc deficiency contributes to blood pressure dysregulation may have an important effect on the treatment of hypertension in chronic disease settings, the team noted. (IANS)

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Here’s Why Diabetes Can Be an Independent Risk Factor for Heart Failure

The study shows that diabetes is an independent risk factor for the development of heart failure in the community dwelling population

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Diabetes
The study shows that diabetes is an independent risk factor for the development of heart failure in the community dwelling population. Pixabay

Heart problems are a common development for people with diabetes and now researchers have found that diabetes is an independent risk factor for the development of heart failure in the community dwelling population.

According to health expert in India, if poorly controlled, diabetes leads to cardiomyopathy resulting in progressive deterioration of pumping capacity of heart.

“Diabetes is also a major risk factor for atherosclerosis and this eventually leads to blockage of coronary arteries. This leads to heart attack or myocardial infarction,” Satish Koul, HOD and Director Internal Medicine, Narayana Superspeciality Hospital, Gurugram, told IANS.

“Due to myocardial infarction, the heart muscle becomes weak and eventually heart fails as a pump leading to congestive heart failure,” Koul added.

According to the current study, published in the journal Mayo Clinic Proceedings, researchers evaluated the long-term impact of diabetes on the development of heart failure, both with preserved ejection fraction – a measurement of the percentage of blood leaving the heart with each contraction – and reduced ejection fraction.

They also looked at mortality in a community population, controlling for hypertension, coronary artery disease and diastolic function.

From an initial group of 2,042 residents of Olmsted County in US, 116 study participants with diabetes were matched 1:2 for age, hypertension, sex, coronary artery disease and diastolic dysfunction to 232 participants without diabetes.

Over the 10-year follow-up period, 21 per cent of participants with diabetes developed heart failure, independent of other causes. In comparison, only 12 per cent of patients without diabetes developed heart failure. Cardiac death, heart attack and stroke were not statistically different in the study between the two groups.

The study shows that diabetes is an independent risk factor for the development of heart failure in the community dwelling population. Furthermore, the outcome data support the concept of a diabetic cardiomyopathy.

Diabetes
Heart problems are a common development for people with diabetes and now researchers have found that diabetes is an independent risk factor for the development of heart failure in the community dwelling population. Pixabay

This research extends previous findings and demonstrates that even without a known cardiac structural abnormality and with a normal ejection fraction, diabetic patients are still at increased risk of developing heart failure as compared to their nondiabetic counterparts.

“The key takeaway is that diabetes mellitus alone is an independent risk factor for the development of heart failure,” said study senior author Horng Chen from Mayo Clinic in the US.

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“Our hope is that this study provides a strong foundation for further investigations into diabetes and heart failure. There is still much to learn and study in terms of this association and how to best diagnose and treat this condition,” Chen added. (IANS)