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Delhi records 3,829 cases of dengue, 502 of chikungunya till date

The year 2015 had reported the highest number of cases of dengue in the city, with the figure standing at 15,867 with 60 deaths.

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cases of dengue
Dengue and Chikungunya are viral diseases transmitted to humans via infected mosquitoes. Pixabay
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New Delhi, November 7, 2017 :  Delhi has so far recorded 3,829 cases of dengue and 502 cases of chikungunya, according to civic agencies on Monday.

While the national capital has witnessed a total of four dengue-related deaths till now, no deaths have been reported due to chikungunya.

ALSO READ You May Soon Be Able to Prevent Chikungunya With Vaccines! IIT-Roorkee Researchers Discover Drug to Fight the Disease

The year 2015 reported the highest number of cases of dengue in the city, with the figure standing at 15,867 with 60 deaths.

As for chikungunya, 2016 saw 7,117 cases — the highest in the last five years.

Civic agencies said that areas under the South Delhi Municipal Corporation reported the maximum cases of chikungunya and dengue this year.

ALSO READ What preventive steps have the city Government taken to control Dengue and Chikungunya, asks the Delhi High Court

Delhi has also reported a total of 552 malaria cases with no deaths so far. The figure is the second-highest after 2012 when the cases had soared to 822. (IANS)

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How Chikungunya Virus Causes Arthritis Pain Decoded

Scientists have identified the molecular handle that chikungunya virus grabs to get inside cells and cause arthritis pain, a finding that could lead to ways to prevent or treat the disease as well as related viruses.

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Scientists have recovered oldest viral genomes of hepatitis B virus (HBV) and found that the deadly virus has been circulating in Europe for at least 7,000 years.
Virus, Representative Image- Pixabay

Scientists have identified the molecular handle that chikungunya virus grabs to get inside cells and cause arthritis pain, a finding that could lead to ways to prevent or treat the disease as well as related viruses.

The study, conducted over mice, identified the protein on cells called Mxra8 that is needed for chikungunya virus to invade both human and mouse cells.

The virus uses Mxra8 protein as a handle to open a door into cells.

The handle, or receptor, is located on cells that build cartilage, muscle and bone. Joints are filled with such cells, which helps explain patients’ painful symptoms.

By creating decoy handles, the researchers showed that they could prevent the virus from grabbing that handle and thus reduce chikungunya infection and signs of arthritis.

“The name chikungunya comes from the Makonde language of Tanzania, and it means ‘to walk bent over.’ That’s how painful the arthritis can be,” said Michael S. Diamond, Professor at the Washington University in St. Louis, US.

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representational image. pixabay

“We now know how chikungunya gets into cells, and we may have found a way to block the infection. If the virus cannot get into the cell, it is unable to replicate and cause infection and disease,” Diamond added.

In the study, published in the journal Nature, the team deluged the virus with decoy handles, so that chikungunya would grab the decoy and be locked out of cells.

A day after infection, the level of virus in the mice’s ankles and calf muscles was between ten-fold and a hundred-fold lower in the animals that had been treated with Mxra8 proteins or blocking antibodies than those that received placebo, and the numbers remained lower over the next two days.

Also Read: Scientists Recover Oldest Virus Genome of HBV

In addition, three days after treatment, the mice that had received the protein exhibited much less swelling in their ankles than those that received the placebo.

The results suggest that a compound that blocks the virus from attaching to Mxra8 on the surface of cells could prevent or reduce arthritis. (IANS)

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