Friday September 21, 2018

Study: Depression Can Be Cut by Ketamine

Ketamine, the drug can be helpful to cut off depression and suicidality

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A man in depression. Pixabay
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Recreational drug Ketamine is likely to have fast-acting benefits in treating symptoms of depression as well as reducing suicidal thoughts, say researchers, including one of an Indian-origin.

The findings of the trial, published in the American Journal of Psychiatry, showed use of Ketamine, also licensed as an anaesthetic, through a nasal spray, led to significant improvements in depressive symptoms and reduction in suicidal thoughts in the first 24 hours.

A woman in depression.
A woman suffering from depression.

Esketamine could be an important treatment to bridge the gap as it can help in the rapid treatment compared to the delayed effects of most common antidepressants, which take four to six weeks to become fully effective, said Jaskaran B. Singh, from the Janssen Research & Development in San Diego, US.

The results support nasal spray esketamine as a possible effective rapid treatment for depressive symptoms in patients assessed to be at imminent risk for suicide, the researchers noted.

For the study, a small group of participants randomly assigned to one of two groups – either receiving esketamine or placebo twice a week for four weeks, and found a significant improvement in depression scores and decreased suicidal ideation in the esketamine group compared to the placebo group at four hours and at 24 hours.

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However, at 25 days, the effects had levelled out.

While there esketamine dependence or misuse was not observed in the trial, the researchers suggested for effective controls on the distribution and use of ketamine.

They argued that steps to control the use of ketamine would not be aimed at preventing its use for beneficial purposes but would allow for treatment to “continue to be available to those with need, while the population that is at-risk for abuse is protected from an epidemic of misuse.”  IANS

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Depression in Children Stay Undetected by Parents and Teachers- Study

The gold standard for identifying children who might be at risk for developing depression later in life is to ask the children themselves

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Depression
Depression in children under-recognised by parents, teachers: Study. Pixabay

Parents and teachers may find it difficult to detect depression in young children, that can affect their social skills and academics, a new study shows.

According to Anxiety and Depression Association of America, as many as 2-3 per cent of children aged between 6-12 might have a major depressive disorder.

But parents and teachers face difficulties in recognising depression in children.

The findings, appearing in the Journal of School Psychology, showed that children who show mild to severe symptoms of depression in second and third grades are six times more likely to have skill deficits, such as difficulties with social skills or academics, than children without symptoms.

However, when teachers and parents were asked to rate a child’s level of depression, there was only about 5-10 per cent overlap in their ratings.

Depression
Parents and teachers face difficulties in recognising depression in children. Pixabay

“Some people would view that overlap as the truth about a child’s well-being and areas of disagreement as errors, but we need to explore the possibility that each of them are seeing different aspects of children’s behaviour and mental health,” said Keith Herman, professor in the University of Missouri (MU), College of Education.

For the study, the team completed profile analyses of 643 children in early elementary school to explore how patterns between student, teacher and parent reporting can be used to gain a holistic picture of a child’s mental health.

Herman suggested that mental health professionals could work with teachers and parents to identify depressive symptoms early by including self reports from children in mental health evaluations.

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“The gold standard for identifying children who might be at risk for developing depression later in life is to ask the children themselves,” noted Herman.

“However, even if a child doesn’t say they feel depressed, certain outward behaviours might provide clues to the state of the child’s mental health. It’s important for teachers and parents to catch these behaviours early to prevent long-term problems that occur with depression,” he said. (IANS)

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