Thursday April 26, 2018

Study: Depression Can Be Cut by Ketamine

Ketamine, the drug can be helpful to cut off depression and suicidality

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A man in depression. Pixabay
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Recreational drug Ketamine is likely to have fast-acting benefits in treating symptoms of depression as well as reducing suicidal thoughts, say researchers, including one of an Indian-origin.

The findings of the trial, published in the American Journal of Psychiatry, showed use of Ketamine, also licensed as an anaesthetic, through a nasal spray, led to significant improvements in depressive symptoms and reduction in suicidal thoughts in the first 24 hours.

A woman in depression.
A woman suffering from depression.

Esketamine could be an important treatment to bridge the gap as it can help in the rapid treatment compared to the delayed effects of most common antidepressants, which take four to six weeks to become fully effective, said Jaskaran B. Singh, from the Janssen Research & Development in San Diego, US.

The results support nasal spray esketamine as a possible effective rapid treatment for depressive symptoms in patients assessed to be at imminent risk for suicide, the researchers noted.

For the study, a small group of participants randomly assigned to one of two groups – either receiving esketamine or placebo twice a week for four weeks, and found a significant improvement in depression scores and decreased suicidal ideation in the esketamine group compared to the placebo group at four hours and at 24 hours.

Also Read: Depression Can Negatively Impact Heart Patients

However, at 25 days, the effects had levelled out.

While there esketamine dependence or misuse was not observed in the trial, the researchers suggested for effective controls on the distribution and use of ketamine.

They argued that steps to control the use of ketamine would not be aimed at preventing its use for beneficial purposes but would allow for treatment to “continue to be available to those with need, while the population that is at-risk for abuse is protected from an epidemic of misuse.”  IANS

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Stronger people have sharper brains: Study

Previous research by the group has already found that aerobic exercise can improve brain health

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workout
It is best to begin your gym workout with a dynamic warm-up routine. Pixabay

 If you thought hitting the gym only builds your physical strength, think again. A study of nearly half a million people has revealed that stronger people perform better in brain functioning tests.

Muscular strength, measured by handgrip, is an indication of how healthy our brains are, said the study published in the journal Schizophrenia Bulletin.

“Our study confirms that people who are stronger do indeed tend to have better functioning brains,” said study co-author Joseph Firth from NICM Health Research Institute, Western Sydney University, Australia.

Strong people have sharper brains. Wikimedia Commons

Using data from the 475,397 participants from all around Britain, the new study showed that on average, stronger people performed better in brain functioning tests that included reaction speed, logical problem solving, and multiple different tests of memory.

The study, which used UK Biobank data, showed the relationships were consistently strong in both people aged under 55 and those aged over 55. Previous studies had only shown this applies in elderly people.

The findings also showed that maximal handgrip was strongly correlated with both visual memory and reaction time in over one thousand people with psychotic disorders such as schizophrenia.

Also Read: Riding a bike to work as good as gym workout: Study

“We can see there is a clear connection between muscular strength and brain health,” Firth, who is also an honorary research fellow at the University of Manchester in Britain, said. “But really, what we need now, are more studies to test if we can actually make our brains healthier by doing things which make our muscles stronger — such as weight training,” he added. Previous research by the group has already found that aerobic exercise can improve brain health. “These sorts of novel interventions, such as weight training, could be particularly beneficial for people with mental health conditions,” Firth said.

“Our research has shown that the connections between muscular strength and brain functioning also exist in people experiencing schizophrenia, major depression and bipolar disorder — all of which can interfere with regular brain functioning,” he added. “This raises the strong possibility that weight training exercises could actually improve both the physical and mental functioning of people with these conditions,” he said. IANS

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