Wednesday December 11, 2019

Depression May Reduce Arginine Levels In Your Body

Arginine is an amino acid which the body uses to produce nitric oxide

0
//
Over 5 crore people in India are known to suffer depressive disorders Pixabay
Over 5 crore people in India are known to suffer depressive disorders Pixabay
  • People with depression have lower arginine levels
  • Taking arginine can help cure depression
  • The tests are still going on

People with a major depressive disorder (MDD) have lower levels of naturally occurring arginine in their body than their non-depressed controls, a study has found.

Arginine — an amino acid which the body uses to produce nitric oxide — is a nervous system and immune defence mediator, which also plays a role in vascular regulation.

Depression reduces arginine levels in the body. Wikimedia Commons
Depression reduces arginine levels in the body. Wikimedia Commons

“It is possible that depression-induced inflammatory responses lead to reduced arginine levels. This may result in insufficient production of nitric oxide for the needs of the nervous system and circulation. However, we don’t know yet what exactly causes reduced arginine bioavailability in people with depression,” said lead author Toni Ali-Sisto, a researcher at the University of Eastern Finland.

“Although our study shows that people with depression have reduced arginine bioavailability, this doesn’t mean that taking an arginine supplement would protect against depression. That’s an area for further research,” Ali-Sisto said.

Also Read: Eat Grapes To Ward Off Depression

The study, published in journal Affective Disorders, involved 99 adults with the diagnosed major depressive disorder and 253 non-depressed controls. The concentrations of three amino acids, namely arginine, citrulline and ornithine, were analysed from their fasting glucose samples, and this data was used to calculate their global arginine bioavailability ratio (GABR).

The GABR is an indicator of the body’s arginine levels, and the ratio has previously been used to measure the body’s capacity to produce nitric oxide.

Arginine can be used to reduce or even cure depression. VOA
Arginine can be used to reduce or even cure depression. VOA

The results showed that people with depression had weaker arginine bioavailability than their non-depressed controls.

However, in people who had recovered from depression the arginine bioavailability was found to be slightly higher than in people who remained depressed, the researchers said. IANS

Next Story

Depression in Parents Responsible for Brain Differences of Kids

Brain differences detected in kids with depressed parents

0
Brain structure
Researchers detect brain differences in children with depressive parents. Lifetime Stock

Researchers have found structural differences in the brains of children at high risk for depression due to parental depressive history.

Depression is a common and debilitating mental health condition that typically arises during adolescence. While the causes of depression are complex, having a parent with depression is one of the biggest known risk factors.

Studies have consistently shown that adolescent children of parents with depression are two to three times more likely to develop depression than those with no parental history of depression.

“The findings highlight a potential risk factor that may lead to the development of depressive disorders during a peak period of onset, said study author Randy P. Auerbach, Associate Professor at Columbia University in the US.

“However, in our prior research, smaller putamen volumes also has been linked to anhedonia–a reduced ability to experience pleasure–which is implicated in depression, substance use, psychosis, and suicidal behaviours,” Auerbach said.

Depression brain
Having a parent with depression is one of the biggest known risk factors for the brain of the child. Lifetime Stock

“Thus, it may be that smaller putamen volume is a transdiagnostic risk factor that may confer vulnerability to broad-based mental disorders,” Auerbach added.

For the study, published in the Journal of the American Academy of Child & Adolescent Psychiatry, the researchers analysed brain images from over 7,000 children in the United States participating in the Adolescent Brain Cognitive development (ABCD) study, led by the National Institutes of Health (NIH).

According to the study, about one-third of the children were in the high-risk group because they had a parent with depression.

Also Read- Intermittent Fasting Benefits Those at Risk for Diabetes: Study

The research found that in the high-risk children, the right putamen–a brain structure linked to reward, motivation, and the experience of pleasure–was smaller than in children with no parental history of depression.

“Understanding differences in the brains of children with familial risk factors for depression may help to improve early identification of those at greatest risk for developing depression themselves, and lead to improved diagnosis and treatment,” said study researcher David Pagliaccio. (IANS)