Tuesday August 20, 2019

Genomic Sequencing-based Test Detect Resistant Mutation In Tuberculosis

Indian firm develops a test to detect drug-resistant TB mutation

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Tuberculosis
Doctors can use direct whole genome sequencing to get information on drug resistance mutations in TB. Pixabay

Genetic diagnostic and drug discovery research firm MedGeneome Labs on Thursday claimed to have developed the first whole genomic sequencing-based test to detect drug-resistant mutation in tuberculosis (TB) bacteria.

“The breakthrough DNA test will enable a doctor to correctly prescribe the most effective drug to a TB patient without a time-consuming trial and error process,” said the city-based clinical data-driven Labs.

Announcing its foray into infectious disease testing in TB, central nervous system (CNS), systemic and eye infections, the company said India had the largest number of multi-drug resistant (MDR) TB cases.

Tuberculosis detection
A breakthrough DNA test will enable doctors to correctly prescribe the most effective medicine to a TB patient. Pixabay

“India has the largest number of MDR-TB cases. Our spit sequence can be a boon for TB patients, clinicians and healthcare agencies to achieve the sustainable development goal of eliminating TB by 2025,” Labs Chief Operating Officer V.L. Ramprasad told reporters here.

“The test is based on the whole-genome sequencing of mycobacterium tuberculosis (MTB), the TB causing bacteria, to assess the mutations in bacteria’s genome and allows a clinician to determine which drug will work for a patient,” he said.

Mumbai-based P.D. Hinduja Hospital and Medical Research Centre head Camilla Rodrigues said the test was validated with 100 samples recording 100 per cent sensitivity and 98.04 per cent specificity compared with line probe assay technology.

tuberculosis
India had the largest number of multi-drug resistant (MDR) TB cases. Pixabay

“Of the 100 samples, 50 were tested in our hospital. The findings in the manuscript are under review for publication,” Rodrigues said on the occasion.

Noting that the process of analyzing the drug resistance was long, which is delaying early treatment for MDR-TB patient, Rodrigues said the current expertise allowed testing resistance only on 4 drugs, which makes the patient wait until testing on all possible drugs concluded.

Also Read: The Health Benefits of Testing Your Cortisol Levels

“Direct whole genome sequencing reveals information on drug resistance mutations for all anti-TB drugs in 10 days. Our testing will help to optimise the management of an MDR-TB patient”, she added. (IANS)

Next Story

U.S. Regulators Approve New Tuberculosis Drug that Shows Dramatic Results

The new drug, Pretomanid, was developed by the nonprofit TB Alliance

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FILE - A tuberculosis patient receives treatment at a clinic in Jakarta, Indonesia. VOA

U.S. regulators Wednesday approved a new tuberculosis drug that when taken with two other medicines shows dramatic results.

The new drug, Pretomanid, was developed by the nonprofit TB Alliance.

A study shows that when taken with taken with two other drugs. Pretomanid cured 90% of patients suffering from a strain of TB that is resistant to other treatments.

The study shows the three-drug cocktail can cure TB in about six months and can also stop patients from spreading the disease in just a few days.

US, Tuberculosis, Drug
U.S. regulators Wednesday approved a new tuberculosis drug that when taken with two other medicines shows dramatic results. Pixabay

Most current TB treatments require patients to take multiple numbers of pills and months of very painful daily shots. This treatment of pills and shots can last as long as two years. Doctors say many patients either give up first or die.

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Tuberculosis generally attacks the lungs and is spread when someone with the infection sneezes or coughs. It kills about 1.6 million people every year worldwide. (VOA)