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They also found that the diabetes drug metformin inhibits the same process and thereby suppresses HIV replication in these cells, in both cell-culture and mouse experiments. Pixabay

A team of researchers has discovered an important vulnerability of the AIDS-causing retrovirus HIV and has shown in preclinical experiments that a widely used diabetes drug, metformin, seems able to exploit this vulnerability.

The findings, published in the journal Nature Immunology, suggest that HIV (human immunodeficiency virus) when it infects immune cells called CD4 T cells, helps fuel its own replication by boosting a key process in the cells’ production of chemical energy.


They also found that the diabetes drug metformin inhibits the same process and thereby suppresses HIV replication in these cells, in both cell-culture and mouse experiments.

“These findings suggest that metformin and other drugs that reduce T cell metabolism might be useful as adjunct therapies for treating HIV,” said the researcher Haitao Guo University of North Carolina.

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About 38 million people around the world are living with HIV infection, according to the World Health Organization’s most recent estimates.

Doctors currently treat these infections with combinations of antiretroviral drugs to suppress HIV replication. However, many patients despite this treatment show signs of residual viral replication and immune impairment.

Even patients who respond well to antiretroviral drugs must take them indefinitely, since HIV inscribes itself into the DNA of some infected cells, and the drugs cannot clear this viral genetic “reservoir.”


A team of researchers has discovered an important vulnerability of the AIDS-causing retrovirus HIV and has shown in preclinical experiments that a widely used diabetes drug, metformin, seems able to exploit this vulnerability. Pixabay

Moreover, the toxicity of anti-HIV drugs means that many patients can take them only intermittently. Thus, despite progress, there is still much room for improvement in HIV treatment.

For the study, the team analyzed CD4-cell gene expression data from a study of HIV-infected people and found that the gene-expression patterns most closely related to poor outcomes among these patients involved an energy-production process called oxidative phosphorylation.

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They then found that drugs and other chemical compounds that inhibit oxidative phosphorylation in CD4 cells can inhibit HIV’s ability to replicate in these cells.

The team confirmed with further experiments in primary human CD4 cells, and in mice with human CD4 cells, that metformin suppresses HIV replication in these cells. (IANS/KR)


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Union Finance Minister Nirmala Sitharaman on Saturday asked the Directorate of Revenue Intelligence (DRI) to prevent dumping of toxic wastes in India.

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Comforting Christmas cocktails help you enjoy the celebrations and get into the festive spirit.

By Olivia Sarkar
It's the holiday season, which means it's time to be merry! As the month of December approaches, we're all in a festive mindset. With Christmas just around the corner, there will be plenty of parties and get-togethers with friends and family.

Comforting Christmas cocktails help you enjoy the celebrations and get into the festive spirit. The Leela Palaces, Hotels, and Resorts offer distinctive cocktails ranging from Hot Toddies to Decadent Egg Nogs. Sit back and enjoy one martini at a time to make the festive season a little brighter.

Dirty Chai Eggnog:

Eggnog is a Christmas favorite that is accustomed to toasts for good health and prosperity. It is an American tradition that has spread around the world. Historically, it has been made using eggs, milk, and alcohol. Our culinary artists have given an Indian twist to this winter drink, making it quintessentially desi!



Recipe:

30 ml Bourbon
30 ml Baileys
90 ml Hot milk tea
Whole Spices
Sweet cream foam to top up

Garnish:
Cinnamon powder and star anise.

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