Saturday August 18, 2018

Diabetes, heart disease together cause early death: Study

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London: People suffering from both diabetes and heart disease are at a greater early death risk than people with just one condition or no disease, a study said.

After analysing more than 135,000 deaths that occurred during prolonged follow-up of almost 1.2 million participants, researchers from the University of Cambridge found that an individual in his/her 60s having both the conditions has an average reduction in life expectancy of about 15 years.

Image credits www.crwf.com
Image credits www.crwf.com

“A combination of diabetes and heart disease is associated with a substantially lower life expectancy,” said Emanuele Di Angelantonio from the department of public health and primary care in a paper that appeared in the journal of the American Medical Association.

At the age of 60 years, men with any two of the conditions would on average have 12 years of reduced life expectancy.

Men with three conditions – diabetes, stroke and heart attack (cardiometabolic diseases) – would have 14 years of reduced life expectancy. For women at the age of 60 years, the corresponding estimates were 13 years and 16 years of reduced life expectancy.

The figures were even more dramatic for patients at a younger age.

At the age of 40 years, men with all three cardio-metabolic conditions would on average have 23 years of reduced life expectancy and for women, the corresponding estimate was 20 years.

“Our results highlight the importance of preventing heart disease and stroke among patients with diabetes, and likewise averting diabetes amongst heart disease patients,” said professor John Danesh, study co-author.

Measures aimed at reducing diabetes and heart disease among this group could have a dramatic impact on their lives, the study said.

(IANS)

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Here’s How Mushrooms can Help in the Treatment of Diabetes

Managing glucose better has implications for diabetes, as well as other metabolic diseases

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Mushrooms
How mushrooms can aid in diabetes treatment, Find out here. Pixabay

Eating white button mushrooms daily can act as a prebiotic by improving microbial community in the gut, which could then improve the regulation of glucose in the liver, a finding that could one day pave way for new diabetes treatments, say researchers.

In the study, feeding white button mushrooms to mice changed the composition of gut microbes — microbiota — to produce more short chain fatty acids, specifically propionate from succinate, according to Margherita T. Cantorna, Professor at Pennsylvania State University in the US.

Previous research has shown that succinate and propionate can change the expression of genes needed to manage glucose production, she said.

“Managing glucose better has implications for diabetes, as well as other metabolic diseases,” Cantorna noted.

The study, reported in the Journal of Functional Foods, used two types of mice who were fed about a daily serving size of the mushrooms. One group had microbiota, the other were germ-free.

Mushrooms
Mushrooms. Pixabay

Consuming the mushrooms set off a chain reaction among the gut bacteria, expanding the population of Prevotella — a bacteria that produces propionate and succinate.

These acids can change the expression of genes that are key to the pathway between the brain and the gut that helps manage the production of glucose, or gluconeogenesis.

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The mushrooms, in this case, serve as a prebiotic, which is a substance that feeds beneficial bacteria that are already existing in the gut. Probiotics are live beneficial bacteria that are introduced into the digestive system.

Beyond the possible beneficial benefits of mushrooms as a prebiotic, Cantorna said that this study also shows more evidence that there is a tight connection between diet and microbiota.

“It’s pretty clear that almost any change you make to the diet, changes the microbiota,” Cantorna added. (IANS)

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