London: People suffering from both diabetes and heart disease are at a greater early death risk than people with just one condition or no disease, a study said.
After analysing more than 135,000 deaths that occurred during prolonged follow-up of almost 1.2 million participants, researchers from the University of Cambridge found that an individual in his/her 60s having both the conditions has an average reduction in life expectancy of about 15 years.
“A combination of diabetes and heart disease is associated with a substantially lower life expectancy,” said Emanuele Di Angelantonio from the department of public health and primary care in a paper that appeared in the journal of the American Medical Association.
At the age of 60 years, men with any two of the conditions would on average have 12 years of reduced life expectancy.
Men with three conditions – diabetes, stroke and heart attack (cardiometabolic diseases) – would have 14 years of reduced life expectancy. For women at the age of 60 years, the corresponding estimates were 13 years and 16 years of reduced life expectancy.
The figures were even more dramatic for patients at a younger age.
At the age of 40 years, men with all three cardio-metabolic conditions would on average have 23 years of reduced life expectancy and for women, the corresponding estimate was 20 years.
“Our results highlight the importance of preventing heart disease and stroke among patients with diabetes, and likewise averting diabetes amongst heart disease patients,” said professor John Danesh, study co-author.
Measures aimed at reducing diabetes and heart disease among this group could have a dramatic impact on their lives, the study said.
New York, Dec 12: If you are suffering from kidney dysfunction, you may be at high risk of developing diabetes, finds a study.
The risk may be attributed to the rising level of urea — the nitrogen-containing waste product in blood, which comes from the breakdown of protein in foods.
Kidneys normally remove urea from the blood, but it can build up when kidney function slows down, resulting in greater insulin resistance as well as secretion in the body.
“We have known for a long time that diabetes is a major risk factor for kidney disease, but now we have a better understanding that kidney disease, through elevated levels of urea, also raises the risk of diabetes,” said the Ziyad Al-Aly, Assistant Professor at the Washington University in St. Louis.
“When urea builds up in the blood because of kidney dysfunction, it often results in increased insulin resistance and impaired insulin secretion,” Ziyad added.
The findings, published in the journal Kidney International, are significant because urea levels can be lowered through medication, diet — for example, by eating less protein — and other means, thereby allowing for improved treatment and possible prevention of diabetes, the researchers said.
For the study, the team evaluated the records of 1.3 million adults without diabetes over a five-year period, beginning in 2003.
Out of these, 117,000 of those without diabetes — or 9 per cent — had elevated urea levels, signalling poor kidney function and were at 23 per cent higher risk of developing diabetes. (IANS)
We at samecondition.com in the previous articles have emphasized the need to quit smoking. Like mentioned earlier, it is true that it is easier said than done. In this article, we would like to communicate to you, in case you already didn’t know, the various recommended practices to adapt while trying to quit smoking. Apart from our articles, you might have come across several sources of the ill effects of smoking. But try adapting a different perspective to look at this issue. The beneficial effects of quitting smoking are aplenty.
It is a common knowledge that nicotine is the addictive substance that keeps you glued to smoking. But to abolish it from your life immediately can have some unfavorable implications: Nicotine withdrawal symptoms are insomnia, anxiety, difficulty to concentrate, intense craving to get your hands-on nicotine, depression etc.
To help you avoid quit as well aid you in a smooth transition towards “ the life without nicotine”, nicotine replacement products are recommended. These products are designed in such a way that they supply nicotine in controlled amounts. This would prepare your physical being to cooperate with your mental efforts to quit. Also, some of these products function on the mechanism of positive reinforcement and desensitizing the nicotine receptors by the nicotine replacement. Some of these products are sold under prescription and some are available over the counter. These are Nicotine transdermal patches, lozenges, inhaler, nasal spray, and chewing gums.
The safety of ‘the otherwise effective nicotine replacement therapy’ during pregnancy, remains to be determined. Nicotine in any form still poses a threat to the fetus. If you are a pregnant woman or have been diagnosed with any health condition like asthma, COPD, diabetes, hypertension, it is advisable to better consult a physician before buying these products on your own.
Nicotine (Transdermal) patches: recommended not to be used alongside cigarette smoking. It has the advantage of moderating and maintaining sustainable levels of nicotine ( lesser than in cigarettes).
2. Nasal spray: available as prescription-only drug and the dosage delivered is tapered over time.
3. Gum: a slow release resin containing nicotine and polacrilin. It has a proved smoking cessation track record of up to 70%. ( available over the counter).
Each of these substances come with their own side effects like sore throat, dry mouth, nausea, dyspepsia etc. But the effects are controlled over a period and hence signal safety with uncontested clarity.
4. Medications: There are some non-nicotine containing pharmacotherapeutic substances (FDA approved and primary line of management) that come to your aid in ‘the quit smoking movement’. Two common examples are Bupropion hydrochloride and Varenicline tartrate. Clonidine, an alpha-2 adrenergic receptor agonist, used for treating hypertension has also demonstrated considerable efficacy but not FDA approved. Yet, it has been endorsed by the US clinical practice guidelines to be prescribed as a second line of treatment for tobacco addiction. Next in line is Nortriptyline, a tricyclic antidepressant, primarily prescribed to treat depression. It has also exhibited potential as the second line of treatment. The research to make patches with this drug is still under process.
An alkaloid called cytisine binds to the nicotinic acetylcholine receptor and in some clinical studies has proved to be superior to the replacement therapy.
Some of these are available commercially and some are still in the process to reach approval. It is heartening to know that the efforts to help people trying to quit are on the rise. Check the approval status of the drugs on the regulatory websites of your country. It is even better to approach a physician to get yourself a medically accurate blueprint to quit smoking.
Did you know? Nicotine vaccines might also become a reality soon. This new line of immunotherapy for smoking cessation is also underway.
The harms due to tobacco will stay away from you if you stay away from tobacco.
People who drink three to four cups of coffee a day are more likely to see health benefits than harm, experiencing lower risks of premature death and heart disease than those who abstain, scientists said on Wednesday.
The research, which collated evidence from more than 200 previous studies, also found coffee consumption was linked to lower risks of diabetes, liver disease, dementia and some cancers.
Three or four cups a day confer the greatest benefit, the scientists said, except for women who are pregnant or who have a higher risk of suffering fractures.
Coffee is one of the most commonly consumed drinks worldwide. To better understand its effects on health, Robin Poole, a public health specialist at Britain’s University of Southampton, led a research team in an “umbrella review” of 201 studies based on observational research and 17 studies based on clinical trials across all countries and all settings.
“Umbrella reviews” synthesize previous pooled analyses to give a clearer summary of diverse research on a particular topic.
“Coffee drinking appears safe within usual patterns of consumption,” Pool’s team concluded in their research, published in the BMJ British medical journal late on Wednesday.
Drinking coffee was consistently linked with a lower risk of death from all causes and from heart disease. The largest reduction in relative risk of premature death is seen in people consuming three cups a day, compared with non-coffee drinkers.
Drinking more than three cups a day was not linked to harm, but the beneficial effects were less pronounced.
Coffee was also associated with a lower risk of several cancers, including prostate, endometrial, skin and liver cancer, as well as type 2 diabetes, gallstones and gout, the researchers said. The greatest benefit was seen for liver conditions such as cirrhosis of the liver.
Poole’s team noted that because their review included mainly observational data, no firm conclusions could be drawn about cause and effect. But they said their findings support other recent reviews and studies of coffee intake. (VOA)