Wednesday April 24, 2019

Exposure to Dim Light Escalates Breast Cancer’s Spread to Bones

X-ray images showed that mice exposed to a light or dim light cycle had much larger tumours and increased bone damage compared with mice kept in a standard light/dark cycle

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Cancer
Cancer Ribbon. Pixabay

Exposure to dim light at night may contribute to spreading of breast cancer to bones, researchers have shown in an animal study.

When breast cancer spreads it often affects bones, cause severe pain and make them fragile. “To date no one has reported that exposure to dim light at night induces circadian disruption, which increases spread of bone metastatic breast cancer,” said Muralidharan Anbalagan, Assistant Professor, at Tulane University in New Orleans.

The findings were presented at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans.

For the preliminary study, the team created a mouse model of bone metastatic breast cancer. They injected oestrogen receptor-positive human breast cancer cells, which have a low propensity to grow in bones, into the tibia (shinbone) of female mice.

Cancer patient
Cancer patient.

Like humans, mice produced a strong night-time circadian melatonin signal, shown to produce strong anti-cancer actions and for promoting sleep.

While one group of mice was kept in the light for 12 hours each day, the other group of three mice in the dark for 12 hours. Another group spent 12 hours in light, followed by 12 hours in dim light at night.

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X-ray images showed that mice exposed to a light or dim light cycle had much larger tumours and increased bone damage compared with mice kept in a standard light/dark cycle, he noted.

“Our research identified the importance of an intact nocturnal circadian melatonin anti-cancer signal in suppressing bone-metastatic breast tumour growth,” Anbalagan said. (IANS)

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Chinese Researchers Reveal Mechanism of Chronic Stress Promoting Breast Cancer Development

Qiang noted that patients with breast cancer, ovarian cancer and stomach cancer often have negative emotions, which in turn accelerates the development of their own tumours

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Breast Cancer
Nano technology offers hope for better cancer testing. Pixabay

Chinese researchers have revealed the mechanism of how chronic stress promotes breast cancer development, shedding light on future clinical treatment for cancer.

Cancer patients often suffer negative emotions such as anxiety, despair and fear, which are risk factors facilitating tumour growth as well as promoting cancer progression. However, the specific mechanisms of how chronic stress affects cancer development remains unknown yet.

Researchers from the Dalian Medical University in China found that chronic stress might increase epinephrine levels, which enhances lactate dehydrogenase A (LDHA) and promotes breast cancer stem-like cells, Xinhua reported.

Using a drug screen that targeted LDHA, they found that Vitamin C reversed the chronic stress-induced cancer stem-like phenotype.

The study demonstrates the critical importance of psychological factors in promoting stem-like properties in breast cancer cells and provides a promising therapeutic approach for breast cancer, according to Liu Qiang, lead researcher at the varsity.

Representational image.

“The LDHA-lowering agent Vitamin C can be a potential approach for combating stress-associated breast cancer,” Qiang said, in the paper published in the Journal of Clinical Investigation.

His team has been engaged in the dynamic regulation of cancer stem cells research as well as the mechanism of psychosocial behaviour affecting tumour development.

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Qiang noted that patients with breast cancer, ovarian cancer and stomach cancer often have negative emotions, which in turn accelerates the development of their own tumours.

“It is necessary to monitor their chronic stress comprehensively by taking psychological assessments as well as conducting blood tests which include epinephrine levels,” Qiang said. (IANS)