Never miss a story

Get subscribed to our newsletter


×
Abiraterone acetate can improve the quality of life for prostate cancer patients. Pixabay

Scientists have discovered a novel formulation of the prostate cancer drug abiraterone acetate that can dramatically improve the quality of life for people suffering from prostate cancer.

Pre-clinical trials by the University of South Australia show the new formulation of the drug – currently marketed as Zytiga – improves the drug’s effectiveness by 40 per cent.


Developed by Professor Clive Prestidge’s Nanostructure and Drug Delivery research group at University of South Australia’s Cancer Research Institute, the breakthrough discovery uses an oil-based oral formulation that not only enables a smaller dose of the drug to be effective, but also has the potential to dramatically reduce possible side effects, such as joint swelling and diarrhoea.

Follow NewsGram on Twitter to stay updated about the World news.

Despite Zytiga being the leading formulation to treat prostate cancer, lead researcher Dr Hayley Schultz said the new formulation will ultimately provide a better treatment for patients with prostate cancer.

Prostate cancer is the most commonly diagnosed cancer in men, with one in six at risk of diagnosis before the age of 85. “Many drugs are poorly water soluble, so when they’re ingested, they enter the gut but don’t dissolve, which means that their therapeutic effect is limited,” said Dr Schultz.


Prostate cancer is the most commonly diagnosed cancer in men, with one in six at risk of diagnosis before the age of 85. Pixabay

“This is the case for Zytiga. Here, only 10 per cent of the dose is absorbed, leaving the other 90 per cent undissolved, where it simply passes through the body as waste”.

On top of this, patients taking Zytiga must fast for two hours prior to taking the drug, and another hour after taking the drug to achieve predictable absorption.

“And as you can imagine, this can be painstakingly inconvenient. Our new formulation changes this. By using oils to mimic pharmaceutical food effects, we’re able to significantly increase the drug’s solubilisation and absorption, making it more effective and a far less invasive treatment for patients,” explained Schultz in a paper published in International Journal of Pharmaceutics.

The new formulation uses very high levels of abiraterone acetate dissolved within a specific oil and encapsulated within porous silica microparticles to form a powder that can be made into tablets or filled into capsules.

Also Read: Mental Maturity Important for any Sportsperson During Pandemic: Patil

Applied to human treatment, it could reduce the dose from 1000mg to 700mg per day, without the need for fasting. Professor Prestidge said if the team can secure funding, clinical trials in humans could be just two years away.

“Based on our knowledge of this drug’s pharmaceutical food effect, we hypothesise its absorption in humans will be extensively improved using this technology”. (IANS)


Popular

Unsplash

Music is the universal language that is spoken by all.

When it comes to our day-to-day life, there are several things which help us enhance our day with every step. One such thing is music. It enhances, motivates and boosts certain aspects of our personality in ways that may not come into notice. There have been several researches on how music affects human brain. Studies show it helps us in recovery and healing, and also, encouraging us to be better if exposed to the right kind and fit.

From kids to elderly, music as a commodity, can be consumed by all. It is the universal language that is spoken by each and every being, from animals to humans to plants, each respond to it in their own ways. Suffice to say, we are united by music and the effect it has over us. Plants, for example, grow better when exposed to good music. Many songs are being composed specifically to enhance and boost their growth. Same is the case for humans. For humans, the right kind of music can boost good health, physically as well as mentally. You might have noticed how in gyms, upbeat music is played. That is to channel energy into everyone present. It adds to the workout. Several researches around the world have shown better physical output when exposed to appropriate music. Fast paced songs with upbeat nature channeled speed and the slower ones slowed downs the listeners, without them noticing. The sub-conscious effects of music are continuously being studied.

Keep Reading Show less
Unsplash

Awareness is the key to heal.

As more and more people are acknowledging the importance of their mental well-being, the wave of awareness the acknowledgment has brought is unprecedented. It may not have paved a clear path towards complete healing but it certainly has shown the way. The awareness is the key to heal. Healing begins only after the problem is identified. Similar to physical illness, the identification of the problem area is the first step. Even in case of a minor wound, when we go to the hospital the nurse first locates the wound. They, then, ask how we got hurt and identify the nature of the wound. Only then, they clean, put ointment and wrap it up if it needs wrapping and protection from air and dust. Sometimes, that protection is not needed. The wound heals out in the open. Same goes when it comes to healing of a mental trauma or illness. Sometimes, we confine in professionals or our loved ones, in order to let it out and process it openly. Sometimes, the trauma reduces with time. In any way, being aware and vigilant is the way to go.

Being knowledgeable about life in general, opens many channels for you. Being knowledgeable about yourself, opens gates inside you that lead to spiritual and general awareness about the concept of self. And the inner awareness is not necessarily internal, it can be seen from the outside as well. When we have positive energy from within it radiates physically as well. Have you encountered someone who’s spiritually awakened and aware? Do they stand out in the crowd? There are prominent examples of people who have made their mark in history, there is Swami Vivekanada, his awakening has revolutionised generations, one live example we can witness is The Dalai Lama.

Keep Reading Show less
Photo by Wikimedia Commons

Game of Thrones taught us some significant lessons

Honestly, who hasn’t watched one of the epic series of HBO– Game of Thrones?

There’s no question that when the first episode of Game of Thrones was released on April 11, 2011, the youth population of the world became exuberant. The main reasons behind this reaction was, first, the theme of the show, and second, the hidden lessons which it put forward.

Keep reading... Show less