Sunday April 5, 2020

DNA Differences May Cause Higher Cancer Risk in Men: Study

According to the researchers, although men may be more exposed to carcinogens due to the type of work they do and at higher risk because they are less likely to consult a doctor, the study has shown that there are also biological factors that increase cancer risk among men

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Cancer
In findings published in the Journal of the National Cancer Institute, researchers have reported that loss of function in certain genes of the sex-determining Y chromosome, which is present only in men, may cause them to have an elevated risk for cancer. Pixabay

DNA differences between men and women may explain why cancer risk is higher in males, according to a new study.

In findings published in the Journal of the National Cancer Institute, researchers have reported that loss of function in certain genes of the sex-determining Y chromosome, which is present only in men, may cause them to have an elevated risk for cancer.

Using data from 9,000 individuals, the researchers studied Y-chromosome gene function in patients with various types of cancer. The findings showed that cancer risk increases with loss of function of six key Y-chromosome genes in various types of cells.

“Recent studies have shown that complete loss of the Y chromosome, which is essential to foetal sex differentiation, occurs, with aging, in the cells of some men,” said study author Juan Ramon Gonzalez from Barcelona Institute for Global Health in Spain.

“Although the loss of the Y chromosome has previously been associated with higher incidence of cancer, the causes of this association are poorly understood,” Gonzalez added.

These six Y-chromosome genes are involved in cell-cycle regulation, the failure of which can lead to tumour development.

According to the study, understanding the biological differences between men and women in cancer is crucial for the development of personalised lines of treatment and prevention.

“Men are not only at higher risk of cancer than women, they also face a worse prognosis. In fact, these differences partially account for the lower life expectancy of men,” Gonzalez added.

According to the researchers, although men may be more exposed to carcinogens due to the type of work they do and at higher risk because they are less likely to consult a doctor, the study has shown that there are also biological factors that increase cancer risk among men.

Cancer
DNA differences between men and women may explain why cancer risk is higher in males, according to a new study. Pixabay

“In fact, it seems that one of these factors can be found in the Y chromosome, the very essence of maleness,” said study lead author Alejandro Caceres.

Suppression of the Y chromosome can occur as a result of loss of function in the chromosome, which would explain previous findings, or as a result of other mechanisms mediated by the chemical (epigenetic) inactivation of the same regions, the research said.

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“Certain environmental exposures, for example to tobacco or other harmful substances, could affect chromosome function and lead to epigenetic modifications,” Gonzalez said. (IANS)

Next Story

Here Are Some Health Benefits of Going Vegan

Veganism is a lifestyle that tries to bar, as far as possible and practicable, all kinds of exploitation of, and cruelty to, animals for food, or any other purpose

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Vegan
Veganism is a lifestyle that tries to bar, as far as possible and practicable, all kinds of exploitation of, and cruelty to, animals for food, or any other purpose. Pixabay

Vegan people follow a plant-based diet and do not eat animal products including dairy, meat, eggs, honey, and gelatin. But, veganism goes beyond the diet.

Veganism is a lifestyle that tries to bar, as far as possible and practicable, all kinds of exploitation of, and cruelty to, animals for food, or any other purpose.

Nutritionist and founder of Diet Podium, Shikha Mahajan, shares these five benefits going vegan has on your health.

Reduced risk of cancer

In 2015, the Worle Health Organisation named red meat a Group 2 Carcinogen, which means it probably causes cancer in humans. WHO placed processed meat in the Group 1 category, which means it is carcinogenic to humans.

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Even small amounts of meat can increase the risk of cancer. A study from Oxford University study also found that eating just 3 rashers of bacon a day can increase cancer risk by 20 percent.

Reduced risk Of diabetes

More and more research is concluding that a plant-based diet can reduce the risk of developing diabetes or even reverse the disease completely.

A study, that included more than 2,000 adults, found those people who increased the number of fruit, vegetables, and nuts in their diet over the duration of 20 years reduced their risk of developing type 2 diabetes by 60 percent more than those who did not.

Enhanced mood

A study done by the Physicians Committee for Responsible Medicine (PCRM) shows a study on its website that looks at the eating patterns and moods of 3,486 people over a five-year period. The study showed that participants who consumed whole, plant foods reported fewer signs of depression.

Vegan
Vegan people follow a plant-based diet and do not eat animal products including dairy, meat, eggs, honey, and gelatin. But, veganism goes beyond the diet. Pixabay

A different study showed that vegetarians usually experience more positive moods than meat-eaters.

Healthy skin

A plant-based diet might boost your beauty regime by assisting your skin in staying healthy. An increasing number of studies are associating dairy to skin problems such as acne. Dairy products have growth hormones and are also sometimes infused with artificial hormones, which can disrupt the human body’s hormone system.

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Fewer cardiovascular diseases

Meat generally contains a high quantity of saturated and trans-fats which can increase blood cholesterol. Cholesterol can create fatty deposits in the blood vessels that increase the risk of stroke, peripheral artery disease, and heart disease. Plant-based foods, by nature, have no dietary cholesterol. A diet high in fat and cholesterol can also lead to high blood pressure. (IANS)