Monday February 17, 2020

DNA Sustains More Damage and Gets Fixed Less Often When Blood Sugar Levels are High

These cancers include ovarian, breast, kidney and others

0
//
DNA, Blood, Sugar
"It's been known for a long time that people with diabetes have as much as a 2.5-fold increased risk for certain cancers," said John Termini from City of Hope, a research and treatment center for cancer and diabetes in the US. Pixabay

Researchers have found that DNA sustains more damage and gets fixed less often when blood sugar levels are high compared to when blood sugar is at a normal, healthy level, thereby increasing one’s cancer risk.

“It’s been known for a long time that people with diabetes have as much as a 2.5-fold increased risk for certain cancers,” said John Termini from City of Hope, a research and treatment center for cancer and diabetes in the US.

These cancers include ovarian, breast, kidney and others. But why people with Type-1 or Type-2 diabetes run higher risk of these cancers has been a mystery for a long time.

The new findings could offer a possible explanation for this double whammy.

DNA, Blood, Sugar
Researchers have found that DNA sustains more damage and gets fixed less often when blood sugar levels are high compared to when blood sugar is at a normal, healthy level, thereby increasing one’s cancer risk. Pixabay

Termini wondered if the elevated blood glucose levels seen in diabetes could harm DNA, making the genome unstable, which could lead to cancer.

So Termini and colleagues looked for a specific type of damage in the form of chemically modified DNA bases, known as adducts, in tissue culture and rodent models of diabetes.

Indeed, they found a DNA adduct, called N2-(1-carboxyethyl)-2′-deoxyguanosine, or CEdG, that occurred more frequently in the diabetic models than in normal cells or mice.

What’s more, high glucose levels interfered with the cells’ process for fixing it.

Also Read- India Needs to Define Special Placement of Function of Intelligence in Interest of National Security

“Exposure to high glucose levels leads to both DNA adducts and the suppression of their repair, which in combination could cause genome instability and cancer,” Termini said.

Termini and colleagues have recently completed a clinical study that measured the levels of CEdG, as well as its counterpart in RNA (CEG), in people with Type-2 diabetes.

As in mice, people with diabetes had significantly higher levels of both CEdG and CEG than people without the disease.

The findings are scheduled to be presented at the American Chemical Society (ACS) Fall 2019 National Meeting and Exposition being held in San Diego, California, from August 25-29. (IANS)

Next Story

Here’s Everything You Need to Know About Anaemia

The road to recovery for anemia in Ayurveda

0
Anaemia
The most common ailment among Indian women is anemia. It means absence of blood and refers to reduction of hemoglobin level in body. Pixabay

BY PUJA GUPTA

The most common health ailment among Indian women is anaemia. It means absence of blood and refers to reduction of hemoglobin level in body. Normal level of hemoglobin in adult females is between 12 to 16 g/dl, while in adult males it is between 14 to 18 g/dl.

In Sanskrit ‘Pandutya’ means whitish colouration. Since anemia is characterized by a whitish tint on skin, eyes and nails, it is called Pandurog in Ayurveda. It can be caused by non-nutritious diet, weak digestive fire, malnutrition or loss of blood, says Dr Partap Chauhan, author, public speaker, TV personality and Director of Jiva Ayurveda.

Chauhan underlines the common causes of this health ailment called anaemia, home remedies and some lifestyle changes to cure the disease.

Anaemia
Anaemia can be caused by non-nutritious diet, weak digestive fire, malnutrition or loss of blood. Pixabay

Common causes: Diminished production, increased destruction or severe loss of red blood cells leads to anaemia. Deficiency of iron, thyroxine, vitamins B12, C & folate results in diminution of RBC production while various infections, toxins, antibodies and congenital structural abnormalities lead to their increased destruction. Other than this, anemia can also be the cause of other serious diseases.

Symptoms of anaemia: Headache, loss of appetite, fatigue, weakness, breathlessness, giddiness, swelling around eyes, whitish tint on skin, nails and eyes, palpitations and sleeplessness

Home remedies: Besides the prescribed medicines, you can follow the below mentioned home remedies.

Anaemia
Headache, loss of appetite, fatigue, weakness, breathlessness, giddiness, swelling around eyes, whitish tint on skin, nails and eyes, palpitations and sleeplessness are symptoms of anaemia. Pixabay

Half a cup of apple juice should be mixed with half a cup of beetroot juice. Put honey into this mixture and stir it well. If the juice can be consumed twice a day, it would take up the hemoglobin level.
The second option is to take the juice of turmeric with daily.
Soak one teaspoon of black sesame seeds in water for two hours. Take the soaked sesame seeds and grind it into a paste. Mix one teaspoon of paste of sesame seeds and honey to a glass of milk. Drink this milk daily to improve the hemoglobin level.

Lifestyle changes: Anemia patients should keep in mind the following points in their daily lives:

Avoid indigestion in your daily lives. Do not take spicy food. Further to this, avoid having non-vegetarian food.

Also Read- Know About the Benefits of Rose Water

Have light meals including lentil soups, vegetable soups. Pomegranate and melons should be included in your diet.
Cook the anemia patient’s food in iron pots. This helps to retain the hemoglobin level in the body.
If you have problems like piles or menstrual problems, take immediate doctor’s advice. (IANS)