Monday March 18, 2019
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Doctors Discovered Antibodies to Fight Ebola

Scientists are hopeful that that therapeutic antibodies could be the best way to stop this virus.

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congo, ebola
Health care workers from the World Health Organization prepare to give an Ebola vaccination to a front-line aid worker in Beni, Democratic Republic of the Congo. VOA

In 1995, a patient sick with the Ebola virus, in what was then called Zaire and is now the Democratic Republic of the Congo, miraculously recovered from this deadly disease. At that time, when the virus first jumped from animals to man, Ebola meant almost certain death.

Doctors found that this patient had antibodies to fight the virus in his bloodstream even after he recovered.

Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health, invited the patient to the U.S., where researchers cloned the cell that had helped him beat Ebola.

“We brought the person back to the United States to draw his blood and try to clone the B cells that make the antibodies that this person had produced … to then, essentially, clear his virus and, hopefully, protect him against any future exposure,” Fauci told VOA.

Because the NIH scientists made numerous copies of that cell, it is called a monoclonal antibody — in this case, mAB114. It’s hoped that it can be used to target the Zaire strain of Ebola currently spreading in eastern Congo.

Fauci said mAB114 is still experimental.

“We have done a number of tests in an animal model and have shown that when you infect an animal up to five days after they become infected, and you passively transfer this antibody, you can actually protect the animals from getting sick and they recover,” he said.

Not all treatments that work in animals work in humans, something Fauci knows all too well. One treatment for HIV/AIDS that Fauci found worked well in monkeys had disastrous effects when tested in humans.

Fauci’s staff is conducting a phase one clinical trial in volunteers at the NIH hospital to make sure mAB114 is safe. So far, no one can say whether the treatment works, but because of the dire situation in Congo, and the fear the virus will spread in the armed conflict that is going on in the region, Fauci said the antibody has been given to five people with Ebola.

Ebola
Director-General of the World Health Organization Tedros Adhanom Ghebreyesus attends a news conference after an emergency committee meeting on the Ebola outbreak in the Democratic Republic of the Congo at the United Nations in Geneva, Switzerland, VOA

At a news conference Tuesday, Dr. Tedros Adhanom Ghebreyesus, director-general of the World Health Organization, said he had been told they were doing well.

As of now, there’s no approved treatment for the disease, although there is a vaccine that protects people who may have been exposed to the virus but who are not sick.

Other experimental treatments are also being used to help end the outbreak in Congo. One of them is ZMapp, a combination of three monoclonal antibodies. In 2016, NIH found ZMapp safe and well-tolerated, but without an outbreak, it is impossible to prove effectiveness.

Fauci said another antiviral drug, remdesivir, is being used in patients with Ebola from West Africa, even though that outbreak is over. Scientists have found the Ebola virus can remain in the semen, so men are being treated to prevent further spread.

Also Read: HPV Vaccones are Effective, Especially for Teens

Remdesivir, or GS-5734, is produced by Gilead. On its website, Gilead says remdesivir is thought to work by blocking a key enzyme the virus needs to reproduce itself. Tomas Cihlar, Gilead’s vice president for biology, is quoted as saying, “Based on animal studies, we believe that the compound is able to penetrate the organs and tissues throughout the body where Ebola replicates.”

So far, there are no proven treatments for Ebola. Scientists are hopeful that that therapeutic antibodies could be the best way to stop this virus. An international study led by Scripps Research suggests that antibodies may be valuable treatments against new viruses and could help a patient’s immune system fight the Ebola virus after being infected. (VOA)

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Ebola Epidemic To Spread in Eastern DRC, Claims WHO

The Ebola outbreak in North Kivu and Ituri provinces is the second largest in history after the 2014 epidemic in West Africa that killed more than 11,000 people.Prior to the recent incidents, progress was being made in containing the spread of the Ebola virus in the DRC.

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Ebola
A health worker in a protective suit walks past burned structures after attackers set fire to an Ebola treatment center run by Medecins Sans Frontieres (MSF) in the east Congolese town of Katwa, Democratic Republic of Congo, Feb. 25, 2019. (Meinie Nicolai/MSF) VOA

The World Health Organization (WHO) says the deadly Ebola virus is likely to spread in the eastern Democratic Republic of Congo because of deteriorating security in conflict-ridden North Kivu and Ituri provinces.

The latest WHO figures put the number of Ebola cases at 885, including 555 deaths.

International efforts to stop the spread of the deadly Ebola virus in eastern DR Congo have hit a serious roadblock. The charity Doctors Without Borders has suspended its life-saving operations. The action follows attacks on two of its Ebola treatment centers this week — the first on February 24 in Katwa, followed by an attack three days later in Butembo.

Burned structures are seen after attackers set fire to an Ebola treatment center run by Medecins Sans Frontieres (MSF) in the east Congolese town of Katwa, Democratic Republic of Congo, Feb. 25, 2019. Picture taken February 25, 2019. (Laurie Bonnaud/MSF)
Burned structures are seen after attackers set fire to an Ebola treatment center run by Medecins Sans Frontieres (MSF) in the east Congolese town of Katwa, Democratic Republic of Congo, Feb. 25, 2019. Picture taken February 25, 2019. (Laurie Bonnaud/MSF) VOA

The World Health Organization called the attacks deplorable and said there is a great risk of the spread of the disease. During the attack on the facility in Butembo, four Ebola patients fled for their lives.

WHO spokesman Christian Lindmeier said three of the patients have since returned, while one is still missing.

“If you want, the positive note is that all of these four patients were convalescent, that means they were already getting better,” he said. “Hence, they had a lower viral load, which makes it way less likely for further infections.But yes, it is highly important to find those people, that last patient and then, of course, immediately start the contact tracing and monitor the contacts these patients might have been in touch with.”

Ebola
International efforts to stop the spread of the deadly Ebola virus in eastern DR Congo have hit a serious roadblock. VOA

Lindmeier said the WHO remains committed to staying in the DRC until the job is done. However, he notes that an Ebola outbreak as complex as this one can only be managed collectively and by having all the partners on the ground. He added that it is normal to expect organizations to do whatever is necessary to protect their staffs.

Also Read: India Should Crack Down Upon The Terror Sympathizers Within The Country

The Ebola outbreak in North Kivu and Ituri provinces is the second largest in history after the 2014 epidemic in West Africa that killed more than 11,000 people.Prior to the recent incidents, progress was being made in containing the spread of the Ebola virus in the DRC.

The WHO reports the disease is now largely under control in the former hot spots of Mangina, Beni, and Komanda.It says more than 250 people have been cured and 80,000 protected through vaccination. (VOA)