Wednesday, September 30, 2020
Home Life Style Health & Fitness Changing the Dose of TB Vaccination may Improve its Efficacy: Study

Changing the Dose of TB Vaccination may Improve its Efficacy: Study

New approach improves efficacy of TB vaccine says a new study

Researchers have shown that simply changing the dose and route of administration from intradermal (ID) to intravenous (IV) greatly increases the vaccine’s ability to protect rhesus macaques from infection following exposure to Mycobacterium tuberculosis (Mtb), the bacterium that causes TB.

Tuberculosis (TB) is the leading infectious cause of death globally, yet the world’s only licensed TB vaccine, Bacille Calmette-Guerin (BCG), was developed a century ago.

Given to infants via a needle placed just under the skin, BCG protects babies from a form of the disease called disseminated TB but is far less effective at preventing pulmonary TB.

The findings from University of Pittsburgh in US, provide a new understanding of the mechanisms of BCG-elicited protection against tuberculosis infection and disease.

In addition, the finding, published in the journal Nature, supports investigation of IV BCG administration in clinical trials to determine whether this route improves its effectiveness in teens and adults.

According to the researchers, to control Mtb infection and prevent clinical disease, a TB vaccine must elicit strong, sustained responses from the immune system’s T cells, specifically those in the lungs. However, the standard, ID, route of BCG administration may not generate enough of these critical cells in the lungs.

TB
A TB vaccine must elicit strong, sustained responses from the immune system’s T cells, specifically those in the lungs. Pixabay

The research team hypothesized that administration of BCG by IV or aerosol (AE) routes would overcome this hurdle and thus confer substantially better protection from infection and disease in rhesus macaques following challenge with virulent Mtb. In their study, groups of animals received the BGC vaccine by ID, AE or IV routes.

The scientists assessed immune responses in blood and in fluid drawn from the lungs for a 24-week period following vaccination. IV BCG vaccination resulted in the highest durable levels of T cells in the blood and lungs.

Six months after vaccination, the researchers exposed groups of vaccinated rhesus macaques (immunized via ID, AE or IV routes) and a group of unvaccinated macaques to a virulent strain of Mtb by introducing the bacteria directly into the animals’ lungs. They then tracked the infection and disease development over three months.

Nine out of 10 animals vaccinated with IV BCG were highly protected; six showed no detectable infection in any tissue tested and three had only very low counts of Mtb bacteria in lung tissue.

Also Read- For Millennials, Owning a Car Means More Sex

All unvaccinated animals and those immunized via ID or AE routes showed signs of significantly greater infection.

The investigators concluded that IV BCG conferred an unprecedented degree of protection in an animal model of severe TB and ‘represents a major step forward in the field of TB vaccine research.’ (IANS)

STAY CONNECTED

19,133FansLike
362FollowersFollow
1,779FollowersFollow

Most Popular

Jewelry: An Investment and a Sentiment

After a tough six months of pandemic (and continuing) wherein most of us were resigned to our homes and restrained ourselves from socializing, finally...

Is There Greater Risk of Heart Disease to Men than Women?

Over the years, multiple researchers have concluded that heart disease impacts men and women differently. It has been noted that in the younger age...

Knowing the Basics of Your Sneaker Shoes

Sneaker Shoes have taken over the world and how! Understandably so, because who would do not want to sport footwear that is not only...

Fusion Taking Over in Indian Kitchens

Owing to the pandemic, food consumption has become a cautious habit and people are highly conscious of what they are eating and where it...

Sean Toy Provides Rudimentary Overview of Nutrition

Nutrition makes up the second half of the exercise equation, with work and effort being the other, yet many who are committed to consistently...

Reviewing the Song ‘Bol re Dilli Bol’ by Kailash Kher

BY RADHIKA TANDON The song Bol re Dilli Bol, vocalized by Kailash Kher, is indeed a thought-provoking song that leaves you gutted to your core....

How To Become An Influencer On Angel Amplifiers

Marketing techniques and strategies are changing. With the advent of the digital age, brands and companies are also evolving, cruising towards online marketing. This...

Virtual ‘Deepotsav’ in Ayodhya Instead of Ram Lila

The Ayodhya administration has denied permission for Ram Lila in Ayodhya due to the coronavirus pandemic, however, the administration has started preparations to organize...

Recent Comments