Saturday July 21, 2018

Study: Drinking and Smoking can cause Problems to the Dental Fillings

Failure of Dental fillings in smokers and alcohol drinkers.

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Smoking causes failure of Dental fillings
Smoking causes failure of Dental fillings. Pixabay
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  • Indulging in smoking or drinking alcohol may not only damage your teeth but also lead to increased incidences of failure in dental fillings, warned researchers.

The findings, led by researchers from the University of Pittsburgh, showed that within two years of the dental procedure, Dental fillings failed more often in patients who drank alcohol, while the overall filling failure rate was higher in men who smoked.

Furthermore, people with a difference in the gene for matrix metalloproteinase (MMP2) — an enzyme found in teeth — were at increased risk of Dental filling failure.

This could be because MMP2 might be able to degrade the bond between the filling and the tooth surface, potentially leading to failure, the researchers said.

The results, published in the journal Frontiers in Medicine, suggest that genetic analysis might help dentists to personalize treatments for their patients, which could lead to improved outcomes.

“A better understanding of individual susceptibility to dental disease and variation in treatment outcomes will allow the dental field to move forward,” said Alexandre Vieira, a researcher from the varsity.

“In the future, genetic information may be used to personalize dental treatments and enhance treatment outcomes,” Vieira added.

For the study, the team from America and Brazil analyzed dental records of 807 patients.
Fillings can fail for a variety of reasons, including re-emergence of the initial tooth decay or the filling becoming detached.

The researchers also examined if newer composite resin Dental fillings are as durable as traditional amalgam fillings, which have been in use for more than 150 years but which contain mercury, a toxic metal.

The researchers found that overall, there were no major differences between patients receiving amalgam or composite Dental fillings in terms of filling failure rates. (IANS)

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What Causes Alcohol Addiction?

The team analysed GAT-3 levels in brain tissue from deceased humans who had documented alcohol addiction

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What Causes Alcohol Addiction?
What Causes Alcohol Addiction? (IANS)

Molecular mechanisms including lower levels of a protein in the brain may be the reason why addicts choose alcohol over an alternative reward, finds a study that may help improve treatment for alcohol dependence.

The study suggested that the level of a transporter protein GAT-3, situated in the amygdala region of the brain — responsible for emotional reactions — was lower among the alcohol addicts.

“We have to understand that a core feature of addiction is that you know it is going to harm you, potentially even kill you, and nevertheless something has gone wrong with the motivational control and you keep doing it,” said Markus Heilig from the Linkoping University in Sweden.

In the study, published in the journal Science, the team used a mouse model to measure the expression of hundreds of genes in five areas of the brain.

What Causes Alcohol Addiction?
Alcoholic beverages. Pixabay

The team investigated the role of reduced GAT-3 levels in rats that initially preferred sweetened water over alcohol. After the reduction, they were again presented with the choice between alcohol and sugar.

They found that 15 per cent of the outbred rats chose alcohol over a high-value reward.

Also Read: US Cancels A Planned Alcohol Study Over Trust Issues

“Decreasing the expression of the transporter had a striking effect on the behaviour of these rats. Animals that had preferred the sweet taste over alcohol reversed their preference and started choosing alcohol,” said lead investigator Eric Augier.

Further, the team analysed GAT-3 levels in brain tissue from deceased humans who had documented alcohol addiction. They found lower levels of the protein in them than in the control individuals. (IANS)

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