Monday January 20, 2020

Donepezil, A Drug Used For Alzheimer Disease, Doubles Hospitalisation Risk

Researchers have found that a drug, donepezil commonly used to manage symptoms of Alzheimer disease and other forms of dementia, is associated with a two-fold higher risk of hospitalisation

0
//
Drugs, Alzheimer, Dementia, Hospitalisation, Risk
Dementia is a growing problem, with almost 10 million newly diagnosed cases every year around the world. Pixabay

Researchers have found that a drug, donepezil commonly used to manage symptoms of Alzheimer disease and other forms of dementia, is associated with a two-fold higher risk of hospitalisation.

According to the study published in the journal Canadian Medical Association Journal (CMAJ), using donepezil increases the risk of hospital admission for rhabdomyolysis, a painful condition of muscle breakdown, compared with several other cholinesterase inhibitors.

Dementia is a growing problem, with almost 10 million newly diagnosed cases every year around the world, said the researchers.

Drugs, Alzheimer, Dementia, Hospitalisation, Risk
Dr. William Burke goes over a PET brain scan, Aug. 14, 2018 at Banner Alzheimers Institute in Phoenix, Arizona. VOA

“The findings of this population-based cohort study support regulatory agency warnings about the risk of donepezil-induced rhabdomyolysis,” said study researcher Jamie Fleet from McMaster University in Canada.

The study, led by researchers at Western University, looked at ICES data from 2002 to 2017 on 2,20,353 patients aged 66 years or older in Ontario, Canada, with a new prescription for donepezil, rivastigmine or galantamine, three cholinesterase inhibitors used to manage dementia and Alzheimer disease.

ALSO READ: Gas-Capturing Capsules To Measure What Gases You Have

The researchers found that donepezil was associated with a two-fold higher risk of hospitalisation for rhabdomyolysis, a serious condition that can result in kidney disease.

According to the findings, the relative risk was small but statistically significant. (IANS)

Next Story

Here’s How Climate Change is Linked To Risk of Wildfires

At the global scale, burned area has decreased in recent decades, largely due to clearing of savannahs for agriculture and increased fire suppression

0
Wildfires
Wildfires can't be prevented, and the risks are increasing because of climate change. This makes it urgent to consider ways of reducing the risks to people. Pixabay

Human-induced climate change has already increased the risk of wildfires globally, researchers say, adding that these wildfires will become more common in future.

In light of the Australian fires, researchers from the University of East Anglia, Met Office Hadley Centre, University of Exeter and Imperial College London have conducted a Rapid Response Review of 57 peer-reviewed papers published since the IPCC’s Fifth Assessment Report in 2013.

All the studies show links between climate change and increased frequency or severity of fire weather – periods with a high fire risk due to a combination of high temperatures, low humidity, low rainfall and often high winds – though some note anomalies in a few regions.

“Wildfires can’t be prevented, and the risks are increasing because of climate change. This makes it urgent to consider ways of reducing the risks to people,” said study researcher Iain Colin Prentice from Imperial College London.

Rising global temperatures, more frequent heatwaves and associated droughts in some regions increase the likelihood of wildfires by stimulating hot and dry conditions, promoting fire weather, which can be used as an overall measure of the impact of climate change on the risk of fires occurring.

Observational data, published on ScienceBrief, shows that fire weather seasons have lengthened across approximately 25 per cent of the Earth’s vegetated surface, resulting in about a 20 per cent an increase in global mean length of the fire weather season.

“Overall, the 57 papers reviewed clearly show human-induced warming has already led to a global increase in the frequency and severity of fire weather, increasing the risks of wildfire,” said study lead author Matthew Jones from the University of East Anglia.

“This has been seen in many regions, including the western US and Canada, southern Europe, Scandinavia and Amazonia. Human-induced warming is also increasing fire risks in other regions, including Siberia and Australia,” Jones added.

Wildfire, Forest, Fire, Blaze, Smoke, Trees, Heat
Human-induced climate change has already increased the risk of wildfires globally, researchers say, adding that these wildfires will become more common in future. Pixabay

“However, there is also evidence that humans have significant potential to control how this fire risk translates into fire activity, in particular through land management decisions and ignition sources,” Jones said.

At the global scale, burned area has decreased in recent decades, largely due to clearing of savannahs for agriculture and increased fire suppression. In contrast, burned area has increased in closed-canopy forests, likely in response to the dual pressures of climate change and forest degradation.

ALSO READ: Amazon Gets Order From Court To Temporarily Block Pentagon Project By Microsoft

“Fire weather does occur naturally but is becoming more severe and widespread due to climate change. Limiting global warming to well below 2 degree celsius would help avoid further increases in the risk of extreme fire weather,” said study researcher Richard Betts. (IANS)