Saturday July 21, 2018

New Therapy for Drug-Resistant Skin Cancer Suggested by Researchers

A team of researchers has managed to exploit a vulnerability in melanoma or skin cancer that develops resistance to a targeted therapy, providing a potential new therapeutic strategy to selectively kill the drug-resistant cancer cells.

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The reason for increased bleeding is not known. It may be because rivaroxaban is more 'potent', the paper published in the Journal of Clinical Oncology said. (IANS)
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A team of researchers has managed to exploit a vulnerability in melanoma or skin cancer that develops resistance to a targeted therapy, providing a potential new therapeutic strategy to selectively kill the drug-resistant cancer cells.

The study has shown that when cancer cells develop drug resistance, they also acquire a new vulnerability, the Xinhua reported.

The researchers, led by Rene Bernards of the Netherlands Cancer Institute and Oncode Institute in Denmark, exposed this new vulnerability in melanoma that has developed resistance to treatment with a BRAF inhibitor — a targeted therapy that blocks a signalling pathway in the cancer cell through which it gets the message to keep on dividing.

Since more than half of all melanoma patients have a mutation in this BRAF gene, the BRAF-inhibitor stops tumour growth in those patients.

But within a few months, the tumour cell adapts the original signalling pathway and becomes active again, and even hyperactive.

The researchers, however, found that the hyperactive resistant melanoma cells produced large amounts of reactive oxygen species, but cancer cells still sensitive to the drug did not do so.

Combining the new compound with vitamin D allowed certain protective genes to be expressed at much higher levels than they are in diseased cells.
Representational image, pixabay

The study, published in the journal Cell, found that the abundance of free radicals caused the resistant melanoma cells to stop dividing, but they did not die.

When tested on mice along with an existing drug, vorinostat, which is known to stimulate the production of free oxygen radicals, the researchers saw tumours shrink under the influence of the drug, the report said.

This laid the foundation for a new therapeutic strategy: Treating patients with BRAF-mutated melanoma, as usual, with signal pathway inhibitors.

When the tumour becomes resistant, stop giving those inhibitors and immediately treat the patients with vorinostat to kill the resistant cancer cells.

Also Read: Leukemia Progression in Kids Can be Delayed Through Bone Density Treatment

“It is not a combination drug. It is very important that you first stop the signalling pathway inhibitors because they suppress the free radicals and thus eliminate the effects of vorinostat,” Bernards said. (IANS)

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Diabetic Women at Greater Risk of Developing Cancer Than Men, According to a New Study

Overall, it was calculated that women with diabetes were six per cent more likely to develop any form of cancer than men with diabetes

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The researchers found that women with diabetes were 27 per cent more likely to develop cancer than women without diabetes but for men the risk was 19 per cent higher.
The researchers found that women with diabetes were 27 per cent more likely to develop cancer than women without diabetes but for men the risk was 19 per cent higher. Pixabay

Women suffering from diabetes may be at a higher risk of developing cancer than men, a new study has found.

The findings suggested that among the study participants, women with diabetes (Type 1 and Type 2) were at higher risks for developing kidney cancer (11 per cent), oral cancer (13 per cent), stomach cancer (14 per cent) and leukaemia (15 per cent) compared to men with the similar condition.

Diabetes affects more than 415 million people worldwide, with five million deaths every year.

According to the researchers, it is believed that heightened blood glucose may have cancer-causing effects by leading to DNA damage.

“The link between diabetes and the risk of developing cancer is now firmly established,” said lead author Toshiaki Ohkuma from The George Institute for Global Health in Australia.

They also found that diabetes was a risk factor for the majority of cancers of specific parts of the body for both men and women.
They also found that diabetes was a risk factor for the majority of cancers of specific parts of the body for both men and women. Pixabay

“The number of people with diabetes has doubled globally in the last 30 years but we still have much to learn about the condition,” Ohkuma added.

For the study, published in the journal Diabetologia, the researchers examined data on all-site cancer events (incident or fatal only) from 121 cohorts that included 19,239,302 individuals.

The researchers found that women with diabetes were 27 per cent more likely to develop cancer than women without diabetes but for men the risk was 19 per cent higher.

Also Read: Eating Dinner Early May Lower Risk of Breast, Prostate Cancer

They also found that diabetes was a risk factor for the majority of cancers of specific parts of the body for both men and women.

Overall, it was calculated that women with diabetes were six per cent more likely to develop any form of cancer than men with diabetes.

“It’s vital that we undertake more research into discovering what is driving this, and for both people with diabetes and the medical community to be aware of the heightened cancer risk for women and men with diabetes,” Ohkuma noted. (IANS)