Saturday January 25, 2020

Researchers Discover a Drug That Can Reduce Arthritis

The researchers said that while the work is promising, they agree that more research is needed to determine the longer term benefits of the Drug

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The Discovered drug holds promise for arthritis treatment. Pixabay

Researchers have identified a drug that can significantly reduce bone and cartilage progression in osteoarthritis.

In a study, published in the journal Annals of Internal Medicine, the researchers found that “MIV-711” — a novel selective cathepsin K inhibitor — can reduce disease progression in osteoarthritis.

However, the drug was not more effective than placebo for reducing pain related to knee osteoarthritis.

Osteoarthritis of the knee is a painful, disabling condition affecting more than 14 million people in the US and hundreds of millions worldwide.

The pain of knee osteoarthritis arises from a series of pathologic processes involving articular cartilage, subchondral bone, synovium, meniscus, and other joint structures, ultimately leading to joint failure and pain-related functional limitations.

A team of researchers led by the University of Leeds in UK, sought to test the hypothesis that cathepsin K inhibitor could alleviate osteoarthritis symptoms by reducing degeneration of bone and cartilage.

In a multi-centre study, 244 patients with primary knee osteoarthritis were randomly assigned to receive either 100 or 200 mg daily of MIV-711 or matched placebo for 26 weeks to evaluate the efficacy, safety, and tolerability of MIV-711.

The primary endpoint of the study was change in pain score, but changes in disease progression were also assessed using quantitative MRI outcomes.

The researchers found that compared with placebo, MIV-711 was associated with less bone remodelling, less cartilage volume loss, and lower levels of bone resorption and collagen loss.

Drug
Researchers have identified a drug that can significantly reduce bone and cartilage progression in osteoarthritis. Wikimedia Commons

However, it showed no beneficial effects on osteoarthritic knee pain.

According to the researchers, further evaluation is needed to confirm the structural benefits of MIV-711 and to determine whether these translate to more tangible benefits on disease symptoms.

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The researchers said that while the work is promising, they agree that more research is needed to determine the longer term benefits of MIV-711. (IANS)

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Top Tips to Personalize Your Fitness Routine

Find a personalised exercise routine for your body

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Fitness
With so many options available in the fitness space, finding the one right for you can be a task. Pixabay

With so many options available in the health, lifestyle fitness space, finding the one right for you can be a task.

Amaresh Ojha, CEO and Founder, Gympik shares his top tips.

1. Assess your fitness level- To assess your fitness progress, calculating the number of beats of your resting heart rate (RHR) is a beneficial way. The RHR should reduce as your fitness improves.

To calculate your RHR, place two fingers on your wrist (radial artery), and then count the number of heart beats you feel in a period of 60 seconds. Make sure to count the first beat as ezero’.

More than 101 is unusually high and not good. Between 81 and 100 is high, but acceptable, between 61 and 80 is average and 60 or less is good.

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Assessing your fitness level can be very helpful. Pixabay

2. Choose what form of exercise works best for you- While any type of physical activity is beneficial for you, different physical activities present different results.

Yoga is a discipline that focuses on breathing methods, meditation, and physical postures. It has a low-impact structure and hence is gentler on the joints. Yoga helps in improving muscle endurance, flexibility and body balance.

Zumba is an amalgamation of both fast and slow dancing, so it works on your whole body, helping you to lose weight and tone every muscle group, predominantly your back and abdominals. It also improves your posture, balance and flexibility. So, if you wish to develop a flamboyant body shape along with enhancing your dance moves, Zumba will be the right choice for you. One concern with this exercise form is that the best result for Zumba comes while working out in groups, so you will have to join a Zumba class to get the best out of this exercise form.

Pilates is largely focused with core strength. It improves muscle tone and strength along with obtaining a leaner look. This exercise form promotes balanced muscle development, flexibility and helps you in gaining a beautiful posture. Hence, the gateway to a graceful personality is through regular Pilates workout. One disadvantage of this type of exercise form is that it misses out on cardio, so it’s not very effective for steady weight loss.

Walking is one of the best exercises that must be an integral part of your fitness schedule. Regular brisk walk can help in preventing heart diseases and managing high blood pressure and type 2 diabetes along with improving the mood. No matter how many hours you spend in the gym, walking is the best way to lose weight and stay healthy. This is one of the exercise forms that can be practised by all.

Cycling is an activity that is gentle on the joints. It burns fat and improves your cardiovascular health. If you wish to increase your stamina and at the same time tone up your muscles, cycling is the best way of doing so. You can easily make it a part of your routine by building it in your day as a means of transport.

Fitness
Consult with your doctor before incorporating a fitness routine in your lifestyle. Pixabay

3. E-Fitness learning platforms can help you analyse the pros and cons of any form of exercise and you can choose the correct type of exercise for yourself once you know the benefits of each type. There are several E-Fitness channels that you can subscribe to and work with a virtual instructor, who will guide you through your fitness journey.

4. Exercise safe and focus on the health concerns. Pre-exercise screening will help you to identify any medical conditions that may put you at a higher risk of enduring a health issue during physical activity. Consult with your doctor before incorporating a fitness routine in your lifestyle. Certain exercises like running on the treadmill, sprinting, heavy weightlifting etc. can prove injurious for heart patients. Similarly, certain breathing exercises in Yoga can prove harmful for asthmatic patients.

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While there are several options available, the most important thing to keep in mind is to choose an exercise that you find fun and can stick to for the long haul. Choose from your preferences and make your exercise time fun. Do you wish to spend time indoors or outdoors? Alone or with friends/people?

If you choose an activity that seems like a burden after some time, you are more likely to abandon a healthy lifestyle. (IANS)