Friday, July 10, 2020
Home Life Style Health & Fitness Researchers Discover a Drug That Can Reduce Arthritis

Researchers Discover a Drug That Can Reduce Arthritis

The researchers said that while the work is promising, they agree that more research is needed to determine the longer term benefits of the Drug

Researchers have identified a drug that can significantly reduce bone and cartilage progression in osteoarthritis.

In a study, published in the journal Annals of Internal Medicine, the researchers found that “MIV-711” — a novel selective cathepsin K inhibitor — can reduce disease progression in osteoarthritis.

However, the drug was not more effective than placebo for reducing pain related to knee osteoarthritis.

Osteoarthritis of the knee is a painful, disabling condition affecting more than 14 million people in the US and hundreds of millions worldwide.

The pain of knee osteoarthritis arises from a series of pathologic processes involving articular cartilage, subchondral bone, synovium, meniscus, and other joint structures, ultimately leading to joint failure and pain-related functional limitations.

A team of researchers led by the University of Leeds in UK, sought to test the hypothesis that cathepsin K inhibitor could alleviate osteoarthritis symptoms by reducing degeneration of bone and cartilage.

In a multi-centre study, 244 patients with primary knee osteoarthritis were randomly assigned to receive either 100 or 200 mg daily of MIV-711 or matched placebo for 26 weeks to evaluate the efficacy, safety, and tolerability of MIV-711.

The primary endpoint of the study was change in pain score, but changes in disease progression were also assessed using quantitative MRI outcomes.

The researchers found that compared with placebo, MIV-711 was associated with less bone remodelling, less cartilage volume loss, and lower levels of bone resorption and collagen loss.

Drug
Researchers have identified a drug that can significantly reduce bone and cartilage progression in osteoarthritis. Wikimedia Commons

However, it showed no beneficial effects on osteoarthritic knee pain.

According to the researchers, further evaluation is needed to confirm the structural benefits of MIV-711 and to determine whether these translate to more tangible benefits on disease symptoms.

ALSO READ: Tips On How To Write a Plagiarism Free Essay

The researchers said that while the work is promising, they agree that more research is needed to determine the longer term benefits of MIV-711. (IANS)

STAY CONNECTED

18,990FansLike
362FollowersFollow
1,783FollowersFollow

Most Popular

Ageing, Muscle Mass and Your Health

We've all battled with a lid that just won't budge. Maybe we tried banging it on the counter or holding it under hot water,...

Tips to Rejuvenate Your Home This Shravan

The fifth month of the Hindu calendar is called 'the holy month of Shravan', known to be a conduit for conveying natural and tremendous...

Here’s How Yoga Improves Reproductive and Sexual Health

Yoga is an ancient method of relaxation, exercise, and healing that has gained a wide following across the world. It rejuvenates the mind, body,...

Research on Link between Humans and Cats on Silk Road

In some news for cat lovers, new analyses done on an almost-complete cat skeleton found during an excavation along the former Silk Road in...

Application Rate per Job Increases by 48% Amid Covid-19 in India

Rate of applications per job has now increased by 48 per cent in India compared to average applications per job in the pre-Covid period,...

Spotify Signs Deal With Archie Comics to Produce Podcasts

Swedish audio streaming giant Spotify on Friday signed an exclusive deal with Archie Comics to produce podcast adaptations starring the comic book publisher's iconic...

3 in 4 Indians Prefer Watching Movies on OTT Platforms Amid Pandemic

Three in four Indians would prefer to watch a movie on various over-the-top (OTT) platforms in the social distancing times compared to just one...

Poor Indian Children Consistently Face Educational Disadvantages: Researchers

Children from poorer households in India consistently experience educational disadvantages as compared to their wealthier peers, say researchers, adding that the girls are more...

Recent Comments