Tuesday February 18, 2020

Researchers Find Drug to Delay Type-1 Diabetes by Two Years

The effects of the drug were greatest in the first year after it was given, said the study published online in The New England Journal of Medicine

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Diabetes
According to the researchers, these novel findings may provide the basis for new therapies for patients who have heart disease complicated by diabetes. Pixabay

In a first, researchers have found that a treatment affecting the immune system effectively slowed the progression to clinical Type-1 diabetes in high risk individuals by two years or more.

“The results have important implications for people, particularly youth, who have relatives with the disease, as these individuals may be at high risk and benefit from early screening and treatment,” said Lisa Spain, Project Scientist from US National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

The study, involving treatment with an anti-CD3 monoclonal antibody (teplizumab), was conducted by Type 1 Diabetes TrialNet, an international collaboration aimed at discovering ways to delay or prevent Type-1 diabetes.

Participants were randomly assigned to either the treatment group, which received a 14-day course of teplizumab, or the control group, which received a placebo.

All participants received glucose tolerance tests regularly until the study was completed, or until they developed clinical Type-1 diabetes – whichever came first.

During the trial, 72 per cent of the people in the control group developed clinical diabetes, compared to only 43 per cent of the teplizumab group.

diabetes
“Although Type-1 and Type-2 diabetes in parents are well-established risk factors for diabetes, we show that gestational diabetes mellitus may be a risk indicator for diabetes in the mother’s children before age 22,” . Pixabay

The median time for people in the control group to develop clinical diabetes was just over 24 months, while those who developed clinical diabetes in the treatment group had a median time of 48 months before progressing to diagnosis.

“The difference in outcomes was striking. This discovery is the first evidence we’ve seen that clinical Type-1 diabetes can be delayed with early preventive treatment,” Spain added.

Type-1 diabetes develops when the immune system’s T cells mistakenly destroy the body’s own insulin-producing beta cells.

Also Read- Cutting Sodium Intake May Prevent 94 Million Premature Deaths From CVD

Insulin is needed to convert glucose into energy. Teplizumab targets T cells to lessen the destruction of beta cells.

The effects of the drug were greatest in the first year after it was given, said the study published online in The New England Journal of Medicine. (IANS)

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Know About the Side Effects of Using Cannabis

Does smoking marijuana affect your sperm count?

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Cannabis
Cannabis is by far the most widely cultivated, trafficked and abused illicit drug. Pixabay

Cannabis is by far the most widely cultivated, trafficked and abused illicit drug. Cannabis is a generic term used to denote the several psychoactive preparations of the plant Cannabis sativa. The major psychoactive constituent in cannabis is THC.

Dr Dushyant Nadar, Director & Head of Department, Urology & Renal Transplant, Fortis Hospital, Noida shares more information:

The geographical spread of those seizures is also global, covering practically every country of the world. About 147 million people, 2.5 per cent of the world population, consume marijuana (annual prevalence) compared with 0.2% consuming cocaine and 0.2 percent consuming opiates. The use of cannabis can cause some serious side effects.

Acute health effects of cannabis use

Marijuana impairs cognitive development (capabilities of learning), including associative processes Marijuana impairs psychomotor performance in a wide variety of tasks, such as motor coordination, divided attention, and operative tasks of many types. Human performance on complex machinery can be impaired for as long as 24 hours after smoking as little as 20 mg of THC in weed. There is an increased risk of motor vehicle accidents among persons who drive when intoxicated by weed.

Cannabis
Cannabis impairs cognitive development (capabilities of learning). Pixabay

Chronic health effects of cannabis use

Selective impairment of cognitive functioning which include the organization and integration of complex information involving various mechanisms of attention and memory processes.

Prolonged use may lead to greater impairment, which may not recover with cessation of use, and which could affect daily life functions; Development of a drug dependence syndrome characterized by a loss of control over cannabis use is likely in chronic users; Weed use can exacerbate schizophrenia in affected individuals; Epithelial injury of the trachea and major bronchi is caused by long-term ,marijuana smoking; Airway injury, lung inflammation, and impaired pulmonary defense against infection from persistent cannabis consumption over prolonged periods; Heavy cannabis consumption is associated with a higher prevalence of symptoms of chronic bronchitis and a higher incidence of acute bronchitis than in the non-smoking cohort

Cannabis
Cannabis use can exacerbate schizophrenia in affected individuals. Pixabay

Effect of cannabis on male infertility

Infertility affects 10-15% of couples, and it has been estimated that a male factor is responsible in approximately half of these cases. Male infertility is diagnosed with the analysis of several semen parameters, such as the number of total sperm, sperm motility, and percentage of sperm cells with a normal morphology. It is known that marijuana, the commonest recreational drug of abuse, has adverse effects on male reproductive physiology. Its use is associated with impotence, decreased testosterone plasma level, impairment of spermatogenesis, production of spermatozoa with abnormal morphology, reduction of sperm motility and viability and, more recently, with the occurrence of non-seminoma germ cell tumors.

The biological mechanisms by which marijuana affects semen quality and hormone levels are not fully known. The active component of marijuana, ?9-tetrahydrocannabinol (THC), binds to the human cannabinoid receptors CB1 and CB2. CB1 receptors are found in the anterior pituitary but have also been identified in the testis, vas deferens, and human sperm cells, leading to a dose-dependent decreased sperm motility and decreased mitochondrial activity in spermatozoa when activated.

Also Read- Researchers Develop Smart Jumpsuit to Spot Neurological Issues in Infants

This makes it possible for marijuana to affect hormone levels and spermatogenesis, as well as the mature sperm cells. A study found that men who used marijuana have an unhealthier lifestyle and health behavior, are often smokers, consume more alcohol, had a higher caffeine intake, were more likely to have had a sexually transmitted disease, and were more likely to have used recreational drugs other than marijuana. (IANS)