Friday January 24, 2020

Drugs of Breast Cancer Useful in Treating Drug-Resistant Lung Tumours

For the study, the researchers targeted a specific interaction between the RAS protein and p110a

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Key gene behind breast cancer identified. Pixabay

A class of drugs used to treat certain breast cancer could help tackle lung cancers that have become resistant to targeted therapies, suggests a study done on mice.

The study showed that lung tumours in mice caused by mutations in a gene called EGFR shrunk significantly when a protein called p110a was blocked by the drugs.

“At the moment, patients with EGFR-mutant lung cancers are given targeted treatments that are very effective for the first few years,” said lead researcher Julian Downward, Associate Research Director of the Francis Crick Institute in the UK.

“These drugs are improving, but unfortunately after a couple of years, cancer usually becomes resistant and starts to grow and spread again. The second line of treatment is currently conventional chemotherapy, which is not targeted and has substantial side-effects,” said Downward.

Importantly, it would be worth investigating whether p110a inhibitors could be used as second-line therapy.

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Cancer Ribbon. Pixabay

Findings, published in Cell Reports, showed that when they blocked this interaction in genetically modified mice with EGFR mutations, their tumours shrank significantly to about a tenth of the space inside the lung.

Before the intervention, the tumours filled around two-thirds of the space inside the lung.

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These drugs could potentially benefit patients with EGFR-mutant lung cancers whose tumours have become resistant to treatment and could be approved for clinical purposes in the near future, the team suggested.

Since the research is at such an early stage, more research in mice and patient cells would be needed, Downward noted. (IANS)

Next Story

How Do Drugs Impact Anxiety Disorder?

Anxiety disorders are a fact of life for many

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Anxiety disorder is a fact of life for many. It occurs when the body’s normal response to stress becomes out of hand, and it begins to produce an anxiety response to harmless situations.  Pixabay

What is anxiety?

Anxiety Disorder is a completely normal response to perceived threats to your wellbeing. Whether it be a driving test, difficult exam or job interview, these are all situations which can commonly be labelled as ‘stressful’.

Any stressor can lead to anxiety, which is best described as an unpleasant feeling of intense fear. Regular levels of anxiety accompanying a stressful situation is a completely normal bodily reaction, but anxiety often morphs into disorders which can be hard to overcome. 

Anxiety disorders are a fact of life for many. These occur when the body’s normal response to stress becomes out of hand, and it begins to produce an anxiety response to harmless situations. 

A couple of examples of anxiety disorders include:

    • Social anxiety disorder. This is defined by a strong anxiety triggered by social situations, particularly ones such as talking in groups, talking to unfamiliar people or giving a speech. The root fear is being judged negatively by others in social situations. 

 

  • Phobias. Phobias are classified as anxiety disorders, as they consist of an extreme fear response to a particular stimuli. A common phobia is arachnophobia, extreme anxiety and fear caused by spiders. 

 

As seen from the examples, anxiety disorders are often centred around stimuli which are not anxiety-provoking for the whole population. That is the key when it comes to disorders.

What can we do to reduce anxiety?

There are multiple common remedies for anxiety, including the following:

  • Therapy, such as cognitive behavioural therapy (CBT).
  • Mindfulness and meditation.
  • Exercise.
  • low carb diets can be anti-inflammatory and in some cases decreases neuro-psychiatric symptoms.
  • Drug-related intervention, from herbal teas and cannabidiol oil to prescription medication like Prozac.. 

The final bullet is the one that we will focus on in this article, as want to gauge how drugs impact anxiety levels, and the testing which has gone into this.

Natural remedies including lifestyle changes such as exercise are often suggested as remedies for mild anxiety. Therapy is often suggested if anxiety becomes a real problem in someone’s life.

There is also a sliding scale of drug-related solutions. Herbal tea could be used to cure mild anxiety, whereas somebody would be prescribed medication like Prozac if their anxiety is severe.

How are drugs used to treat anxiety?

Different medication is prescribed depending on the severity of anxiety. For example, antidepressants and SSRIs such as Prozac, Zoloft and Paxil would only be administered if a patient was suffering from chronic anxiety. In this case, the drugs act on the brain’s neural pathways to alter the way in which the neurotransmitter serotonin is used. 

Alternatively, antihistamines and beta-blockers are often recommended for more mild cases of anxiety. Rather than being taken daily in order to restructure the brain’s behavior, these are usually taken when anxiety occurs or before an anxiety-producing event.

For immediate relief of more acute anxiety, benzodiazepines such as diazepam and clonazepam are usually taken. However, these often receive bad press for their side effects which can include drowsiness, irritability and a physical dependence on the drug. 

How do we find out which anti-anxiety drugs are safe for human use? Ethical animal testing is often the answer.

Anxiety, Fear, Stress, Emotion, Wooden
Anxiety is a completely normal response to perceived threats to your wellbeing. Whether it be a driving test, difficult exam or job interview, these are all situations which can commonly be labelled as ‘stressful’. Pixabay

Testing for anti-anxiety solutions, particularly in rodents

Rodents are often used in scientific experiments which aim to identify new treatments for anxiety in humans. Considering the relative similarities of key brain structures, we can observe the effects of anxiety-provoking situations on rodents to know which parts of the brain could be involved in anxiety responses.

Lezak, 2017, provides excellent discussion on the testing of rodents for anxiety-like symptoms. He describes the stimuli we provide as ‘assays’, rather than ‘models’. By definition, a model is required to have extreme detail and be thoroughly tested. 

One assay commonly used for anxiety measurement in rodents is the Open Field Test. This really is a basic test, involving a box in which a rodent is placed. The box is lined with tall walls which can be set to either clear or opaque. 

Typically, a rodent feeling more anxiety-like would tend to stick close to the walls of the box, and venture out into the middle very little. Conversely, a ‘happy’ rodent would be explorative, and spend time in the open space in the middle of the box. It is also possible to analyze other behaviors of the rodent such as rearing, grooming and freezing, to judge its levels of confidence in its surroundings.

A simple study into measuring the effects of drugs on rodents in an Open Field Test would be to administer a benzodiazepine and record the difference in anxiety-like behaviors. There have been studies which confirm the reduction in rodent anxiety-like behaviors after administering a benzodiazepine, but which also report other changes in behavior such as shifts in locomotor pattern.

Any unexpected or additional effects which drugs have on rodents must be seriously considered before a drug is approved for human usage.

Can drugs also contribute to anxiety negatively?

So far, we have covered the ways in which drugs can be used to treat anxiety. However, it is also true that certain drugs can worsen the symptoms of anxiety.

Substance-induced anxiety disorders are the name given to anxiety, panic and fear caused by the taking of a drug, or stopping taking a drug. 

Alcohol, as well as illegal drugs such as cocaine and LSD can be responsible for substance-induced anxiety disorders. This may be because of thoughts associated with the use of the drugs: “I’m worried that I’m too dependent on this drug”, “I know that if I stop taking this drug, my anxiety levels will go through the roof”. 

As well as fear caused by the drug, there are other symptoms like insomnia, memory loss and difficulty breathing which can all contribute to increased anxiety levels after taking these drugs.

Abuse of stimulants and steroids in particular will cause a pounding, irregular heartbeat and racing thoughts. 

In short, misusing any type of drug can lead to substance-induced anxiety disorders. If you already suffer from anxiety, the best course of action is to consult a doctor and take the drugs recommended to you, in their recommended doses.

Anxiety, Stress, Depression, Mental Health, Loneliness
anxiety disorders are often centred around stimuli which are not anxiety-provoking for the whole population. That is the key when it comes to disorders. Pixabay

The power of drugs on our mental wellbeing

It is clear that drugs have the capacity to affect our mental state in both positive and negative ways. In particular, anxiety is a symptom easily influenced by psychoactive drugs. 

Understanding exactly what anxiety is, as well as knowing which types of drugs fit each severity level, will go a long way to fighting this disruptive mental disorder off. 

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Author bio: 

Shuhan He is a physician and scientist, founder of ConductScience.com – a company that creates translational science tools for outcomes in science. The aim of the company is to improve the scientific community by making it easier to access top-quality scientific equipment.

He also works as an emergency medicine physician at the Massachusetts General Hospital.