Monday April 22, 2019

Drugs That Suppress Immune System May Protect Against Parkinson’s

Immunosuppresive drugs likely to keep Parkinson's at bay

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Your work emails can affect your health, relationships
Your work emails can affect your health, relationships Pixabay

People who are on drugs to suppress their immune system are less likely to develop Parkinson’s disease — a neurological disorder characterised by tremors, slow movements, stiffness and difficulty walking, a new study claimed.

The results, published in the journal Annals of Clinical and Translational Neurology, showed that people with several types of autoimmune diseases, including ulcerative colitis were less likely to be diagnosed with Parkinson’s than the general population.

The investigators noted that many autoimmune diseases have one common thing, that is, they are treated with drugs that dampen immune activity.

“We’ve found that taking certain classes of immunosuppressant drugs reduces the risk of developing Parkinson’s. One group of drugs in particular looks really promising and warrants further investigation to determine whether it can slow disease progression,” said Brad Racette from Washington University-St. Louis in the US.

Representational image.
Representational image. Pixabay

The study showed that people taking corticosteroids — used for treating inflammatory diseases — such as prednisone were 20 per cent less likely to be diagnosed with Parkinson’s, while those on inosine monophosphate dehydrogenase (IMDH)– an enzyme — inhibitors were about one-third less likely.

While, immunosuppresive drugs may keep Parkinson’s at bay, it may ,however, increase the chances of developing infectious diseases and cancer.

The benefits of these drugs outweigh the costs for people with serious autoimmune diseases like rheumatoid arthritis but doctors would probably hesitate to prescribe risky drugs to healthy people to stave off Parkinson’s, especially since there is no reliable way to predict who is on track to develop the disease, the team explained.

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“What we really need is a drug for people who are newly diagnosed, to prevent the disease from worsening. It’s a reasonable assumption that if a drug reduces the risk of getting Parkinson’s, it also will slow disease progression, and we’re exploring that now,” Racette said.

For the study, the team analysed prescription drug data on 48,295 people diagnosed with Parkinson’s and 52,324 people never diagnosed with Parkinson’s and developed an algorithm to predict which people would be diagnosed with the disease. (IANS)

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Research Reveals, Cancer Patients Are More Likely To Use Marijuana

"Medical marijuana legislation has previously been associated with reduction in hospitalisations related to opioid dependence or abuse, suggesting if patients are in fact substituting marijuana for opioid, this may introduce an opportunity for reducing opioid-related morbidity and mortality,"

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The researchers found significantly increased use of marijuana over time -- likely reflecting increased availability due to legislative changes -- but they found stable rates of opioid use. Pixabay

Many cancer patients use marijuana and its usage has increased, a new study suggests. The findings, published in the journal CANCER, indicate 40.3 per cent cancer patients used marijuana within the past year, compared with 38 per cent of respondents without cancer.

“Prospective clinical trials are needed to quantify the efficacy of marijuana in cancer-specific pain as well as the risk of opioid misuse in this patient population,” said co-author Kathryn Ries Tringale from the University of California, San Diego.

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They found patients with cancer were more likely to use prescription opioids than adults without cancer — 13.9 per cent versus 6.4 per cent. Pixabay

For the study, 826 people with cancer were matched to 1,652 controls.

The researchers found significantly increased use of marijuana over time — likely reflecting increased availability due to legislative changes — but they found stable rates of opioid use.

Doctor

“Prospective clinical trials are needed to quantify the efficacy of marijuana in cancer-specific pain as well as the risk of opioid misuse in this patient population,” said co-author Kathryn Ries Tringale from the University of California, San Diego. VOA

They found patients with cancer were more likely to use prescription opioids than adults without cancer — 13.9 per cent versus 6.4 per cent.

Also Read: Risk to Obscure Creature, Highlights Pangolin Seizures in Asia

“Medical marijuana legislation has previously been associated with reduction in hospitalisations related to opioid dependence or abuse, suggesting if patients are in fact substituting marijuana for opioid, this may introduce an opportunity for reducing opioid-related morbidity and mortality,” said lead author Jona Hattangadi-Gluth from the varsity. (IANS)