Monday October 21, 2019

Nicotine Present in E-cigarette Increases Risk of Chronic Bronchitis, Says Study

The researchers concluded that nicotine produced these negative effects by stimulating the ion channel transient receptor potential ankyrin 1 (TRPA1)

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E-cigarettes
E-cigarettes is considered to be safer than tobacco cigarettes. Pixabay

E-cigarette vaping with nicotine not only hampers mucus clearance from the airways, but also increases the risk of chronic bronchitis, warn researchers.

A single session of vaping can deliver more nicotine in the airways than smoking one cigarette, warned researchers in a study published in the American Journal of Respiratory and Critical Care Medicine.

“The question was whether vape containing nicotine had negative effects on the ability to clear secretions from the airways similar to tobacco smoke,” said Matthias Salathe, senior author of the study and Professor at the University of Kansas.

The study’s findings showed that vaping with nicotine impaired ciliary beat frequency, dehydrates airway fluid and made mucus more viscous or sticky.

These changes make it more difficult for the bronchi, the main passageways to the lung, to defend themselves from infection and injury.

FILE – A smoker exhales vapor from an e-cigarette at the Vapor Spot, in Sacramento, California, in this July 7, 2015, photo. VOA

“Vaping with nicotine is not harmless as commonly assumed by those who start vaping. At the very least, it increases the risk of chronic bronchitis,” Salathe said.

The researchers observed that exposing human airway cells to e-cigarette vapour containing nicotine resulted in a decreased ability to move mucus or phlegm across the surface. This phenomenon is called “mucociliary dysfunction.”

Mucociliary dysfunction is a feature of many lung diseases, including asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis.

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For the study, the researchers tested the effects of nicotine-containing e-cigarette vapours on airway mucociliary function in differentiated human bronchial epithelial cells (HBECs) and sheep, whose airways mimic those of humans when exposed to e-cigarette vapour.

The researchers concluded that nicotine produced these negative effects by stimulating the ion channel transient receptor potential ankyrin 1 (TRPA1). Blocking TRPA1 reduced the effects of nicotine on clearance in both human cells in culture and in the sheep. (IANS)

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FDA Opens Criminal Probe into E-Cigarette-Related Lung Illnesses in United States

There were seven deaths and 530 confirmed or suspected cases of serious illness related to vaping by late Thursday

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FDA, Criminal, E-Cigarette
Health and Human Services Secretary Alex Azar, left, and acting FDA Commissioner Ned Sharpless speak with reporters after a meeting about vaping with President Donald Trump in the Oval Office of the White House, Sept. 11, 2019, in Washington. VOA

Federal regulators have opened a criminal probe into e-cigarette-related lung illnesses in the United States.

There were seven deaths and 530 confirmed or suspected cases of serious illness related to vaping by late Thursday.

The Food and Drug Administration says it has no intention of prosecuting e-cigarette users, but says its criminal investigations division can help federal authorities figure out why people are getting sick.

The Centers for Disease Control and Prevention is urging people to stop vaping. But it says no one should go back to smoking tobacco cigarettes, urging smokers to get counseling or use FDA-approved products to stop smoking.

FDA, Criminal, E-Cigarette
Federal regulators have opened a criminal probe into e-cigarette-related lung illnesses in the United States. Pixabay

Health experts have been unable to pinpoint an exact cause of vaping-related lung illnesses, including a specific brand or ingredient in e-cigarettes. But some suspect the use of the marijuana component THC in vaping devices.

E-cigarette devices have been marketed as a safer alternative to tobacco. Federal regulators have warned the largest e-cigarette maker, JUUL, against making such claims, saying they have not been proven.

New York this week became the first state to immediately ban flavored e-cigarettes, saying the fruit and candy flavors used in vaping devices are meant to appeal to young people.

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Only tobacco and menthol flavors can be sold in New York. Michigan has also approved a ban on flavors, but it has not taken effect yet. Other states are also considering a ban. (VOA)