Wednesday January 29, 2020

Early Onset of Menstruation Associated with Higher Risk of Diabetes

This new study, analysing more than 15,000 postmenopausal women in China, has found that women who begin menstruating at an earlier age have a higher risk of developing Type-2 diabetes

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Diabetes
According to the researchers, these novel findings may provide the basis for new therapies for patients who have heart disease complicated by diabetes. Pixabay

Early onset of menstruation is associated with a higher risk of Type-2 diabetes, but body mass index (BMI) may mediate this link, says a study.

Each year of delay in menarche age correlated with a six per cent lower risk of Type-2 diabetes, said the study published in the journal Menopause.

“Earlier onset of menses (14 y) was associated with diabetes in later life, likely driven by adult BMI (body mass index),” said Stephanie Faubion, Medical Director, North American Menopause Society (NAMS).

“Other factors such as nutrition and BMI in childhood may also play a role in this association,” Faubion added.

diabetes
Diabetes is the ninth leading cause of death in women and claims 2.1 million female lives every year, more so than men. Pixabay

Type-2 diabetes mellitus has become one of the most common diseases worldwide. In 2015, it affected nearly 8.8 per cent of people aged 20 to 79 globally, and by 2040, it is expected to affect 10.4 per cent.

With so many people affected, it is not surprising how much research has been devoted to identifying determinants of the disease in order to prevent its development. Various lifestyle and environmental factors have already been confirmed, but there is also growing evidence pointing to some physiologic factors.

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This new study, analysing more than 15,000 postmenopausal women in China, has found that women who begin menstruating at an earlier age have a higher risk of developing Type-2 diabetes. (IANS)

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Children of Mothers With Diabetes Are Likely To Suffer From Heart Diseases, Says Study

The researchers also found higher rates for specific types of CVD children of mothers with diabetes

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Diabetes
Diabetes was categorised as pregestational (before pregnancy) or gestational (during pregnancy) and women with diabetic complications were identified in the Study. Pixabay

Children of mothers with diabetes have increased rates of early onset cardiovascular disease or CVD (conditions affecting the heart or blood vessels) from childhood up to the age of 40, the researchers have warned.

The increased rates were more pronounced among children of mothers with a history of CVD or diabetic complications, said the study published in the journal The BMJ.

“Our study provides evidence that children of mothers with diabetes, especially those with a history of CVD or with diabetic complications, had increased rates of early onset CVD throughout the early decades of life,” said study researchers from Aarhus University in Denmark.

If this association is shown to be causal, preventing, screening, and treating diabetes in women of childbearing age could be important not only for improving the health of the women but also for reducing long term risks of CVD in their offspring, the researchers added

The number of women diagnosed with diabetes before or during pregnancy has increased globally, and children of these women are more likely to have risk factors for future CVD, such as high blood pressure and high blood sugar levels. It is unclear, however, whether or to what extent exposure to diabetes in the womb increases the risk of developing CVD in offspring over a lifetime.

So an international team of researchers set out to evaluate associations between diabetes diagnosed before or during pregnancy and early onset CVD in children during their first four decades of life. They base their findings on national registry data for over 2.4 million children born without congenital heart disease in Denmark from 1977 to 2016.

Diabetes was categorised as pregestational (before pregnancy) or gestational (during pregnancy) and women with diabetic complications were identified.

Diabetes
Children of mothers with diabetes have increased rates of early onset cardiovascular disease or CVD (conditions affecting the heart or blood vessels) from childhood up to the age of 40, the researchers have warned. Pixabay

Other potentially influential factors, such as mother’s age, education, lifestyle and medical history were also taken into account. During up to 40 years of follow-up, children of mothers with diabetes had a 29 per cent increased overall rate of early onset CVD compared with children of mothers who did not have diabetes (cumulative risks: 17.8 per cent vs 13.1 per cent ).

The researchers also found higher rates for specific types of CVD children of mothers with diabetes, particularly heart failure (45 per cent), hypertensive disease (78 per cent), deep vein thrombosis (82 per cent), and pulmonary embolism (91 per cent).

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Increased rates were seen in each age group in childhood (before 20 years of age) and early adulthood (from 20 to 40 years of age), regardless of the type of diabetes they were exposed to (pregestational or gestational) and rates were similar for both type 1 and type 2 diabetes, the study said. (IANS)