Friday August 17, 2018

Children Threatened By Ebola Outbreak In DRC

Ebola is highly contagious, killing between 20 and 90 percent of its victims, and the UN children’s fund is engaging communities in the fight against Ebola.

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Ebola
UNICEF spokesman, Christophe Boulierac said schools are crucial for minimizing the risk of transmission among children.
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Children attend a class session at the Wangata commune school during a vaccination campaign against the outbreak of Ebola, in Mbandaka in the Democratic Republic of Congo, May 23, 2018.

The UN children’s fund warned the Ebola outbreak in Democratic Republic of Congo threatens the health and well-being of children, and special care must be taken to help them survive.

Ebola is highly contagious, killing between 20 and 90 percent of its victims, and the UN children’s fund is engaging communities in the fight against Ebola. UNICEF spokesman, Christophe Boulierac said schools are crucial for minimizing the risk of transmission among children.

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There is as you mention, rightly, the risk of stigma and the risk that the child when his father, his care-giver, his mother is affected; the child is psychologically affected. Pixabay

“UNICEF is scaling up prevention efforts in schools across all three affected health zones,” he said. “This includes on-going efforts to install hand washing units in 277 schools and supporting awareness raising activities reaching more than 13,000 children in Mbandaka, Bikoro and Iboko.”

Previous outbreaks of Ebola in DRC and most recently in the horrific epidemic in West Africa have shown the high-level of trauma experienced by children at the loss of family members. Boulierac told VOA orphaned children often become social outcasts because of their association with this fatal disease.

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“There is as you mention, rightly, the risk of stigma and the risk that the child when his father, his care-giver, his mother is affected; the child is psychologically affected,” he said.

Boulierac said UNICEF is taking preventive measures, including providing trained therapists to families affected by the Ebola outbreak and helping children cope psychologically with the trauma of losing loved ones. (VOA)

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Doctors Discovered Antibodies to Fight Ebola

Scientists are hopeful that that therapeutic antibodies could be the best way to stop this virus.

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Health care workers from the World Health Organization prepare to give an Ebola vaccination to a front-line aid worker in Beni, Democratic Republic of the Congo. VOA

In 1995, a patient sick with the Ebola virus, in what was then called Zaire and is now the Democratic Republic of the Congo, miraculously recovered from this deadly disease. At that time, when the virus first jumped from animals to man, Ebola meant almost certain death.

Doctors found that this patient had antibodies to fight the virus in his bloodstream even after he recovered.

Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health, invited the patient to the U.S., where researchers cloned the cell that had helped him beat Ebola.

“We brought the person back to the United States to draw his blood and try to clone the B cells that make the antibodies that this person had produced … to then, essentially, clear his virus and, hopefully, protect him against any future exposure,” Fauci told VOA.

Because the NIH scientists made numerous copies of that cell, it is called a monoclonal antibody — in this case, mAB114. It’s hoped that it can be used to target the Zaire strain of Ebola currently spreading in eastern Congo.

Fauci said mAB114 is still experimental.

“We have done a number of tests in an animal model and have shown that when you infect an animal up to five days after they become infected, and you passively transfer this antibody, you can actually protect the animals from getting sick and they recover,” he said.

Not all treatments that work in animals work in humans, something Fauci knows all too well. One treatment for HIV/AIDS that Fauci found worked well in monkeys had disastrous effects when tested in humans.

Fauci’s staff is conducting a phase one clinical trial in volunteers at the NIH hospital to make sure mAB114 is safe. So far, no one can say whether the treatment works, but because of the dire situation in Congo, and the fear the virus will spread in the armed conflict that is going on in the region, Fauci said the antibody has been given to five people with Ebola.

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Director-General of the World Health Organization Tedros Adhanom Ghebreyesus attends a news conference after an emergency committee meeting on the Ebola outbreak in the Democratic Republic of the Congo at the United Nations in Geneva, Switzerland, VOA

At a news conference Tuesday, Dr. Tedros Adhanom Ghebreyesus, director-general of the World Health Organization, said he had been told they were doing well.

As of now, there’s no approved treatment for the disease, although there is a vaccine that protects people who may have been exposed to the virus but who are not sick.

Other experimental treatments are also being used to help end the outbreak in Congo. One of them is ZMapp, a combination of three monoclonal antibodies. In 2016, NIH found ZMapp safe and well-tolerated, but without an outbreak, it is impossible to prove effectiveness.

Fauci said another antiviral drug, remdesivir, is being used in patients with Ebola from West Africa, even though that outbreak is over. Scientists have found the Ebola virus can remain in the semen, so men are being treated to prevent further spread.

Also Read: HPV Vaccones are Effective, Especially for Teens

Remdesivir, or GS-5734, is produced by Gilead. On its website, Gilead says remdesivir is thought to work by blocking a key enzyme the virus needs to reproduce itself. Tomas Cihlar, Gilead’s vice president for biology, is quoted as saying, “Based on animal studies, we believe that the compound is able to penetrate the organs and tissues throughout the body where Ebola replicates.”

So far, there are no proven treatments for Ebola. Scientists are hopeful that that therapeutic antibodies could be the best way to stop this virus. An international study led by Scripps Research suggests that antibodies may be valuable treatments against new viruses and could help a patient’s immune system fight the Ebola virus after being infected. (VOA)

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