Monday April 22, 2019

Study Shows Eczema Drug is Effective Against Severe Asthma

An eczema drug may help alleviate asthma symptoms as well as improve patients' lung function better than standard therapies, results from twin studies have shown.

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Asthma
Asthma Patients May be Over-Medicating. Wikimedia Commons

An eczema drug may help alleviate asthma symptoms as well as improve patients’ lung function better than standard therapies, results from twin studies have shown.

Dupilumab, an injectable anti-inflammatory drug, was approved in 2017 by the US Food and Drug Administration as a treatment for eczema, a chronic skin disease.

The findings showed that the rate of asthma exacerbations — such as such as wheezing, coughing, shortness of breath and tightness in the chest — was almost cut in half for those taking dupilumab compared with those taking a placebo.

“This drug not only reduced severe symptoms of asthma, it improved the ability to breathe,” said Mario Castro, Professor at the Washington University in St. Louis.

“That’s important because these patients have a chronic disabling disease that worsens over time with the loss of lung function. So far, we do not have a drug for asthma that changes the course of the disease,” Castro added.

By joining two drugs, one of Arthritis could be solution to skin cancer: Wikimedia commons

Although the drug significantly reduced asthma symptoms for all patients, dupilumab worked particularly well in patients with high numbers of a specific type of white blood cell, called eosinophils, circulating in the bloodstream.

For those patients, asthma exacerbations were cut by two-thirds, the researchers said.

The drug also helped wean severe asthma patients off of chronic oral steroids, which can cause debilitating long-term side effects, including stunted growth, diabetes, cataracts and osteoporosis, Castro said.

For the studies, published in The New England Journal of Medicine, the team included more than 2,000 patients who suffered from moderate to severe asthma.

Also Read: Mother’s vitamin B levels during pregnancy may affect child’s Eczema risk

In patients with moderate to severe asthma who used at least three different inhalers to control their symptoms, dupilumab drug, regardless of dose, improved lung function by approximately 130-200 milliliters greater than those receiving the placebo.

The drug also improved their rates of emergency room (ER) visits and hospitalizations. (IANS)

Next Story

Car Pollution: The Cause of Asthma Among Over 350,000 Children in India

South Korea (31 per cent) had the highest proportion of traffic pollution-attributable childhood asthma incidence. The UK ranked 24th of the 194 countries, the US 25th, China 19th, and India 58th

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odd even scheme

Traffic pollution caused asthma among 350,000 children in India, the second largest after China, in 2015, finds a Lancet study that analysed 194 countries.

The study, published in the Lancet Planetary Health, found that the largest number of cases (760,000) of traffic pollution-related asthma were in China.

It could be because China has the second largest population of children and the third highest concentration of nitrogen dioxide (NO2), which is an indicator of traffic pollution.

India had the next largest number of cases (350,000) due to its large population of children, said researchers from the George Washington University in the US. The US (240,000), Indonesia (160,000) and Brazil (140,000) had the next largest burdens.

“Our findings suggest millions of new cases of paediatric asthma could be prevented in cities around the world by reducing air pollution,” said Susan C. Anenberg, Associate Professor at the George Washington University in the US.

Car emissions contribute to global climate change. Pixabay

Globally, the study suggests there are 170 new cases of traffic pollution-related asthma per 100,000 children every year, and 13 per cent of childhood asthma cases diagnosed each year are linked to traffic pollution.

South Korea (31 per cent) had the highest proportion of traffic pollution-attributable childhood asthma incidence. The UK ranked 24th of the 194 countries, the US 25th, China 19th, and India 58th.

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India ranks below other countries for this metric because although levels of other pollutants (particularly PM2.5) in the country are among the highest in the world, NO2 levels (between 2010 and 2012) in Indian cities appear to be lower than or comparable with European and US cities, the researchers said.

“Improving access to cleaner forms of transportation, like electric public transport and active commuting by cycling and walking, would not only lower NO2 levels but would also reduce asthma, enhance physical fitness and cut greenhouse gas emissions,” Anenberg said. (IANS)