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Taking oral drugs daily can be an effective treatment for nearly 10 million cancer patients worldwide suffering from a deadly blood clot condition, results from a clinical trial have shown.
People with cancer have an increased risk of developing blood clots, with roughly one in five experiencing venous thromboembolism (VTE) — either a blood clot in a deep vein or a condition in which one or more arteries in the lungs become blocked by a blood clot.
The results from the clinical trial called “select-d” suggested that prescribing the oral drug rivaroxaban significantly reduced VTE recurrence among patients with cancer.
“Clinicians were already adopting the oral drug into practice for non-cancer patients and now they have data from this study to indicate that this form of treatment is an alternative option for many cancer patients who have a clot,” said lead author Annie Young, Professor at the University of Warwick in Britain.
Although there are many causes and risk factors for VTE, cancer patients are particularly at risk due to a combination of factors such as immobility, pancreatic and gastric tumours as well as chemotherapy, the researcher said.
For the “select-d” trial, researchers enrolled 406 patients who had cancer and VTE; most (69 per cent) were receiving cancer treatment (typically chemotherapy) at the time of their VTE.
Half were randomly assigned to receive low-molecular-weight heparin (dalteparin) and half were given the oral drug rivaroxaban. After six months of treatment, the VTE recurrence rate was four per cent among those taking the tablet and 11 per cent in those receiving dalteparin.
The results for secondary outcomes were mixed, the researcher said.
In patients receiving rivaroxaban, there were around the same percentage of major bleeding events (6 per cent) as those receiving dalteparin (4 per cent) but a marked and significant increase in clinically relevant non-major bleeds (13 per cent) with rivaroxaban compared to those having low molecular weight heparin (4 per cent).
The reason for increased bleeding is not known. It may be because rivaroxaban is more ‘potent’, the paper published in the Journal of Clinical Oncology said. (IANS)
India opener Rohit Sharma, wicket-keeper Rishabh Pant and off-spinner Ravichandran Ashwin have been included in the ICC Men's Test team of the year for 2021. New Zealand captain Kane Williamson has been given the charge of captaining the eleven which also has his countryman and Player of the Match in the inaugural World Test Championship final, Kyle Jamieson, as well. Apart from three Indians and two New Zealanders, England captain Joe Root, Australia's Marnus Labuschagne, Sri Lanka's Dimuth Karunaratne, and Pakistani trio of Fawad Alam, Hasan Ali and Shaheen Afridi are in the eleven as well.
Both of the centuries were memorable knocks in contrasting conditions against England. AaDil / Unsplash
It is Ashwin's fifth appearance and Pant's second time in the Test team of the year honors while it is the first time Sharma is in the coveted eleven of Test cricket. 2021 was the year when Sharma came into his own as an opener in the longest format of the game for India. He cracked 906 runs in the calendar year at an average of 47.68 with two centuries and four half-centuries. Both of the centuries were memorable knocks in contrasting conditions against England -- one at home in Chennai and the other in overcast conditions away from home at the Oval. Though Sharma missed out on the recent Test tour to South Africa, he will have a key role to play for India in 2022.
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Pant, in 2021, further established himself as India's first-choice wicketkeeper-batter in all three formats, with his continuous development especially coming to the fore in the Test arena. He scored 748 runs in 12 matches at an average of 39.36 with a memorable ton against England at Ahmedabad, a 97 against Australia, and an unbeaten 89 against the same opposition at The Gabba in leading India to a memorable Border-Gavaskar Trophy victory by 2-1. He also accounted for 39 dismissals in 23 innings, with his glovework continuing to improve. Recently, in Cape Town, Pant scored a high-quality hundred despite India losing the series to South Africa 2-1.
Rohit cracked 906 runs in the calendar year at an average of 47.68.Wikipedia
Ashwin, the off-spinner bamboozled many batters with his sheer wizardry to be the leading wicket-taker in Test cricket in 2021. Ashwin scalped up 54 wickets in nine matches at an average of 16.64, making a big impact in the home series against England and New Zealand. He also chipped in with 355 runs at an average of 25.35, which included a vital century against England at his home ground in Chennai. ICC Men's Test Team of the Year: Dimuth Karunaratne, Rohit Sharma, Marnus Labuschagne, Joe Root, Kane Williamson (captain), Fawad Alam, Rishabh Pant (wicket-keeper), Ravichandran Ashwin, Kyle Jamieson, Hasan Ali, and Shaheen Afridi. (IANS/SP)
(Keywords : cricket, Test, India, mans, Rohit Sharma, Rishabh Pant, Ravichandran Ashwin, batter, bowler, wicket-keeper, ICC, honor, century, wickets, team, spinner, opener, dismissals.)
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BY DEVIKANANDA JI
ॐ पितृदेवार्चितभूम्यै नमः
(Piṫa: Father; Archiṫa: One who is honored or worshipped)
In Sanskrit, the word pita means- one who protects. The Taiṫṫirīya Upanishad declares that the father is only next to the mother and should be honored like a god; without the father, you don't exist. This is proper since he gives birth, education and culture to his offspring. According to the smrutis, it is the father who performs the upanayana sacrament and imparts the sacred Gāyatrī mantra to his sons. According to some dharma śhāstra works, the following are pitās or fathers:- anna dāta (one who gives food); bhayatrāta (one who protects from dangers); śvaśura (father-in-law); janita (father) upaneta (one who performs upanayana).
Only in the Vedic tradition do we equate the father with god and honor and respect him. He is responsible for your birth and without his dhāṫu (sperm) you don't exist. He also provides food, shelter, and a roof over your head. He provides worldly knowledge for you to survive in the world. Without a father, you don't have a wife or mother because without him, they also don't exist. Every human being according to Hinduism, is said to be born under three ruṇas or debts. Among these is pitruruṇam. This ruṇa can be paid by marrying according to dharma and having a son who will perform śrāddhas to the pitrus or departed ancestors, thereby appeasing them. For Hindus, the father is honored and worshipped as a god and his children serve him in his old age.
From Vedic times to the beginning of Kaliyuga, and even today there are children who follow the father's occupation and keep the family business or tradition. From the father we inherit some traits, gotram, and family name. A father also has the burden and responsibility to maintain his life style according to dharmaśhāstrās because his children are going to look up to him and imitate him. In the great epic Mahābhārata, Yakṣha (a semi-divine being) asks Yudhishṭara, the eldest of the Pāndavās what the ātman (soul) is for the father. Yudhishṭara replies that 'putra ātmā manushyaśya' meaning- the son is the ātman for the father. He adds that -father is higher than the sky.
Our mother land has the culture of honoring and worshiping the father and is 'Pitrudevārchita Bhūmi'.
(Key Words: Father, God, Family, Vedas, Vedic, Tradition, Hinduism)
Bollywood actor Arjun Kapoor was never really keen on exploring horror comedy but the story of 'Bhoot Police' pushed him to try his hand at the genre. The actor said, "It's not a genre that I was looking for, script-wise. When I heard it, when I read it, what worked for me was the camaraderie between the brothers, the friction and the banter between them. So I quite liked the friction, the brotherhood and at the same time the love-hate relationship and the witty tone."
The film is set for its world TV premiere on Star Gold.Unsplash
He further said, "There was a certain canvas and a certain color created in the script itself, so my decision to say yes to the film came from the director's vision, and thankfully it came at a point where I knew the passion Saif had, also because everybody knew in the industry he is so bullish on the script." On his camaraderie with Arjun in the film, Saif mentioned, "Arjun and I have a relationship off-camera too; he is a family friend and we have known each other for ages! On camera, we don't take each other for granted and bring out the best we can. We had a good time working together and that shows in the movie."
The film is set for its world TV premiere on Star Gold, sharing his excitement for the premiere, Arjun said, "I cannot wait for the audiences to enjoy the World TV Premiere of our movie, 'Bhoot Police' on 23 January, Sunday at 8 PM on Star Gold." The 'Ishaqzaade' actor added, "'Bhoot Police' is an ideal family watch. Usually, horror-comedies are not children-friendly. But Bhoot Police is the kind of film the whole family can watch together over dinner. It is not often that you get a film that is mildly frightening and can be watched with the whole family. The kids will definitely enjoy watching the movie with their family!"
The actor said, "It's not a genre that I was looking for, script-wise."Unsplash
Speaking about her role in 'Bhoot Police', Yami Gautam said, "The character Maya that I play in 'Bhoot Police' was physically challenging. We had to shoot under tough weather conditions because the cold was bitter. There were a lot of outdoor sequences and keeping the light and weather in mind, we had to pack a lot within a day, every day." She continued, "Whenever I am in Himachal, I feel a sense of belonging; when I see the sunrise, those snow-capped mountains despite long tiring night shoots. It is my birthplace and shall always have a special place in my heart." (IANS/SP)
(Keywords : Arjun Kapoor, Yami Gautam, Saif Ali Khan, Bhoot Police, horror comedy, challenging, weather, mountains, genre, script, director, camera, movie.)
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