Friday September 21, 2018

Effective Treatment to Protect Cancer Patients From Blood Clots

Taking oral drugs daily can be an effective treatment for nearly 10 million cancer patients worldwide suffering from a deadly blood clot condition, results from a clinical trial have showed.

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Taking oral drugs daily can be an effective treatment for nearly 10 million cancer patients worldwide suffering from a deadly blood clot condition, results from a clinical trial have shown.

People with cancer have an increased risk of developing blood clots, with roughly one in five experiencing venous thromboembolism (VTE) — either a blood clot in a deep vein or a condition in which one or more arteries in the lungs become blocked by a blood clot.

The results from the clinical trial called “select-d” suggested that prescribing the oral drug rivaroxaban significantly reduced VTE recurrence among patients with cancer.

“Clinicians were already adopting the oral drug into practice for non-cancer patients and now they have data from this study to indicate that this form of treatment is an alternative option for many cancer patients who have a clot,” said lead author Annie Young, Professor at the University of Warwick in Britain.

Although there are many causes and risk factors for VTE, cancer patients are particularly at risk due to a combination of factors such as immobility, pancreatic and gastric tumours as well as chemotherapy, the researcher said.

The reason for increased bleeding is not known. It may be because rivaroxaban is more 'potent', the paper published in the Journal of Clinical Oncology said. (IANS)
Representational image, pixabay

For the “select-d” trial, researchers enrolled 406 patients who had cancer and VTE; most (69 per cent) were receiving cancer treatment (typically chemotherapy) at the time of their VTE.

Half were randomly assigned to receive low-molecular-weight heparin (dalteparin) and half were given the oral drug rivaroxaban. After six months of treatment, the VTE recurrence rate was four per cent among those taking the tablet and 11 per cent in those receiving dalteparin.

The results for secondary outcomes were mixed, the researcher said.

In patients receiving rivaroxaban, there were around the same percentage of major bleeding events (6 per cent) as those receiving dalteparin (4 per cent) but a marked and significant increase in clinically relevant non-major bleeds (13 per cent) with rivaroxaban compared to those having low molecular weight heparin (4 per cent).

Also Read: Drug Used For Osteoporosis May Help in Reducing Heart Attack Risk

The reason for increased bleeding is not known. It may be because rivaroxaban is more ‘potent’, the paper published in the Journal of Clinical Oncology said. (IANS)

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Gut Microbiota Can Help Identify Liver Cancer: Researchers

Gut microbiota can help the body digest certain foods that the stomach and small intestine have not been able to digest.

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Liver Cancer
How gut microbiota can aid in early diagnosis of liver cancer.

Chinese researchers have identified gut microbiota as a new biomarker of liver cancer, that can help in early diagnosis as well as treatment of the condition.

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the third leading cause of cancer-related death worldwide.

Due to the absence of specific symptoms in early stages and the lack of diagnostic markers, most patients with HCC are often diagnosed in an advanced stage.

Liver Cancer
AFP is a plasma protein that is produced in abundance by the liver cells. Pixabay

Researchers from China’s Zhejiang University, and Zhengzhou University, found that the microbial diversity in patients with cirrhosis was significantly lower than that in healthy people, but it increased when cirrhosis develops into cancer, the Xinhua reported.

Human gut microbiota has been considered the most important micro-ecosystem living with the body, containing tens of trillions of microorganisms, including at least 1,000 species of bacteria with more than 3 million genes.

Gut microbiota can help the body digest certain foods that the stomach and small intestine have not been able to digest.

Liver Cancer
A high-magnification image from a 2012 glioblastoma case is seen as an example in this College of American Pathologists image released from Northfield. VOA

For the study, appearing in the journal Gut, the team collected 486 fecal samples from across the country.

Also Read: Deaths Due to Cancer Increases to More Than 18 Mn Every Year: WHO

About 12 bacteria genera decreased and six increased in patients with early cancer compared with healthy people.

According to researchers, more data and further studies are needed to confirm the validity and reliability of the model. (IANS)