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This research aims to build a simplified model of the whole brain and use it to develop applications in medicine and engineering, the team said. Pixabay

A team of researchers at the Indian Institute of Technology (IIT) Madras has found energy deficiency in certain cells in the human brain to be a major cause for Parkinson’s disease, a neurodegenerative disorder.

According to the team, it is known that Parkinson’s disease is caused by the loss of dopaminergic cells (located in the central nervous system) in substantia nigra pars compacta (SNc), a key component of the ventral midbrain.


“It is quite remarkable that loss of neurons in a small nucleus like SNc can have wide-ranging, devastating effects in all the four major domains of brain function — sensory-motor, cognitive, affective and autonomous,” V. Srinivasa Chakravarthy from the institution said in a statement.

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“The sequence of the three computational studies suggests that metabolic deficiency within the basal ganglia circuit is the common underlying factor at the subcellular, cellular and network level in Parkinson’s disease. Thus, we have a reasonably comprehensive theory of the pathogenesis of Parkinson’s disease,” Chakravarthy added.

For the study, published in the International Journal of Scientific Reports, the team developed a computational model that showed that energy deficiency might be a major cause of SNc cell loss in Parkinson’s disease.


A team of researchers at the Indian Institute of Technology (IIT) Madras has found energy deficiency in certain cells in the human brain to be a major cause for Parkinson’s disease, a neurodegenerative disorder. Pixabay

At the subcellular level, metabolic deficiency leads to changes like including alpha-synuclein aggregation, reactive oxygen species production, calcium elevation, and dopamine dysfunction, which are characteristic subcellular changes in Parkinson’s disease, the study indicated.

This research aims to build a simplified model of the whole brain and use it to develop applications in medicine and engineering, the team said.

ALSO READ: Study: Hidden Dust In Indian Homes Is Affecting People’s Health

Parkinson’s disease is the second most prominent neurodegenerative disease around the globe after Alzheimer’s disease. (IANS/KR)


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Rihanna was summoned from her seat to accept the honour, with the Prime Minister.

Singer Rihanna was honoured by Prime Minister Mia Mottley at an event which marked Barbados's new status as a republic, which was attended by Prince Charles. Addressing the pop star by her real name, the PM said: "Robyn Rihanna Fenty tomorrow morning shall have conferred upon her the order of national hero of Barbados."

Rihanna was then summoned from her seat to accept the honor, with the Prime Minister managing to rouse a laugh from the singer when she referenced her 2012 hit 'Diamonds', reports femalefirst.co.uk. She added: "On behalf of a grateful nation, but an even prouder people, we therefore present to you, the designee, for the national hero of Barbados." "And to accept on behalf of a grateful nation - you can come my dear - ambassador Robyn Rihanna Fenty, may you continue to shine like a diamond and bring honor to your nation." Rihanna, who was born in the St Michael parish of Barbados, found fame in 2005 after being spotted by a record producer and has since gone on to become one of the most successful female artists of all time with sales of over 250 million and recently reached billionaire status through her Fenty beauty brand.

The Prime Minister continued in her speech: "Commanding the imagination of the world through the pursuit of excellence, her creativity, her discipline, and above all else, her extraordinary commitment to the land of her birth. "Having satisfied that, Ambassador Robyn Rihanna Fenty has given service to Barbados which has been exemplified by visionary and pioneering leadership, extraordinary achievement and the attaining of the highest excellence to the Government of Barbados." It comes after a historic move for Barbados, which has become a republic after almost 400 years and welcomes its first president, Sandra Mason, after removing Queen Elizabeth as head of state. (IANS/ MBI)


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