Thursday November 15, 2018

An enzyme has been identified to stop Ebola infection

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An enzyme has been identified to stop Ebola infection
An enzyme has been identified to stop Ebola infection. wikimedia commons
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London, Dec 30, 2017: Raising hope for an effective drug to treat people with Ebola virus, researchers have found that an enzyme could help prevent the deadly virus from spreading.

The enzyme takes away the virus’ ability to copy itself and thus produce more virus particles and more infection, said the study published in the journal Molecular Cell.

‘When the Ebola virus enters the human cell, its only purpose is to copy itself, fast. First it must copy all its proteins, then its genetic material,” said Jakob Nilsson, Professor at University of Copenhagen in Denmark.

“But by inhibiting a specific enzyme we rob the Ebola virus of its ability to copy itself. And that may potentially prevent an Ebola infection from spreading,” Nilsson said.

There is currently no available treatment for Ebola virus infection.

However, the researchers behind the new study found what is called a new host factor for Ebola virus.

It can be described as a small part of the host’s — for example the human body’s — own cells, which the Ebola virus uses to copy itself and produce more infection.

The virus uses the host factor enzyme PP2A-B56 to start producing proteins.

So when PP2A-B56 is switched off, the virus’ ability to copy itself and produce more infection is stopped.

“When we inhibit the PP2A-B56 enzyme, we remove the first link in a long process, which ends with Ebola spreading. And we can tell that it works,” Nilsson said.

“The Ebola infection in cell cultures where we have inhibited the PP2A-B56 enzyme is 10 times smaller after 24 hours compared to infections where we have not inhibited this enzyme,” Nilsson added.

But because the researchers have so far focused on cell cultures, there is still work to be done before their results can be used to treat people infected with Ebola.

Initially the researchers hope to be able to test it on animals and, in the long term, develop a drug that inhibits the relevant enzyme. (IANS)

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Eastern Congo Suffers From a Deadly Ebola Outbreak

Some people still refuse to believe Ebola exists and have hidden infected family members.

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Ebola, WHO
In this photo taken Sept 9, 2018, a health worker sprays disinfectant on his colleague after working at an Ebola treatment center in Beni, DRC. VOA

An outbreak of Ebola in the eastern region of the Democratic Republic of Congo has killed more than 200 people. Almost 300 Ebola cases have been confirmed since the outbreak began in August, authorities say.

The health ministry said half of the cases were in Beni, a city of 800,000 people, in the North Kivu province.

The outbreak is in a conflict zone where dozens of armed groups operate. Aid agencies have been forced to suspend or slow down their work on several occasions since the outbreak.

Ebola, WHO
A health care worker from the World Health Organization, left, gives an Ebola vaccination to a front line aid worker who will then vaccinate people who might potentially have the virus, in Mbandaka, Congo. VOA

Health Minister Oly Ilunga said his response teams “have faced threats, physical assaults, repeated destruction of their equipment and kidnapping.”

“Two of our colleagues in the Rapid Response Medical Unit have even lost their lives in an attack,” Ilunga said.

Ebola was detected in the DRC in 1976. The current outbreak is the tenth since it was first discovered.

The World Health Organization has warned the virus could spread to nearby countries, including Uganda, Rwanda and Burundi.

congo, ebola
Health care workers from the World Health Organization prepare to give an Ebola vaccination to a front-line aid worker in Beni, Democratic Republic of the Congo. VOA

Medical workers have lots of experience dealing with Ebola outbreaks in the DRC. Fortunately, they have new tools to fight the deadly virus. A new vaccine has shown it can protect people who’ve come into contact with Ebola victims, and more people have learned techniques to keep the virus from spreading.

Also Read: Uganda Readies Itself To Fight Off Ebola From The DRC Border

However, old problems persist with every outbreak. Some people still refuse to believe Ebola exists and have hidden infected family members. Traditional burial practices also put people at risk. (VOA)