Tuesday September 25, 2018

An enzyme has been identified to stop Ebola infection

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An enzyme has been identified to stop Ebola infection
An enzyme has been identified to stop Ebola infection. wikimedia commons
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London, Dec 30, 2017: Raising hope for an effective drug to treat people with Ebola virus, researchers have found that an enzyme could help prevent the deadly virus from spreading.

The enzyme takes away the virus’ ability to copy itself and thus produce more virus particles and more infection, said the study published in the journal Molecular Cell.

‘When the Ebola virus enters the human cell, its only purpose is to copy itself, fast. First it must copy all its proteins, then its genetic material,” said Jakob Nilsson, Professor at University of Copenhagen in Denmark.

“But by inhibiting a specific enzyme we rob the Ebola virus of its ability to copy itself. And that may potentially prevent an Ebola infection from spreading,” Nilsson said.

There is currently no available treatment for Ebola virus infection.

However, the researchers behind the new study found what is called a new host factor for Ebola virus.

It can be described as a small part of the host’s — for example the human body’s — own cells, which the Ebola virus uses to copy itself and produce more infection.

The virus uses the host factor enzyme PP2A-B56 to start producing proteins.

So when PP2A-B56 is switched off, the virus’ ability to copy itself and produce more infection is stopped.

“When we inhibit the PP2A-B56 enzyme, we remove the first link in a long process, which ends with Ebola spreading. And we can tell that it works,” Nilsson said.

“The Ebola infection in cell cultures where we have inhibited the PP2A-B56 enzyme is 10 times smaller after 24 hours compared to infections where we have not inhibited this enzyme,” Nilsson added.

But because the researchers have so far focused on cell cultures, there is still work to be done before their results can be used to treat people infected with Ebola.

Initially the researchers hope to be able to test it on animals and, in the long term, develop a drug that inhibits the relevant enzyme. (IANS)

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Ebola-Stricken Congo Suffers From A Rebel Attack

The latest Ebola outbreak, which causes hemorrhagic fever, vomiting and diarrhea, is believed to have killed 99 people since July and infected another 48.

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Ebola, congo
The violence "will have a considerable impact on the whole response to Ebola," a local public health official told Reuters on condition of anonymity. VOA

At least 14 civilians were killed on Saturday in a six-hour attack by rebels on the town of Beni in eastern Democratic Republic of Congo, local officials told Reuters, warning the unrest may hamper efforts to quash an Ebola epidemic in the area.

The latest outbreak of the deadly disease has been focused in North Kivu and Ituri provinces, which have been a tinder box of armed rebellion and ethnic killing since two civil wars in the late 1990s.

Militants believed to belong to the Allied Democratic Forces, a Ugandan Islamist group active in eastern Congo, clashed with Congolese troops in Beni, a town of several hundred thousand people, local civil society leader Kizito Bin Hangi said by telephone.

“Beni is ungovernable this morning. Several protests have been declared in the town where the people express their anger with consternation,” he said.

Ebola, UNICEF. congo
A boy runs past a dispenser containing water mixed with disinfectant, east of Mbandaka, DRC. VOA

In addition to the known fatalities, dozens of civilians were wounded as they fled the violence, which broke out in the early hours of Saturday evening and lasted until midnight, Bin Hangi added.

A spokesman for the army declined immediate comment.

The attack underscores the challenges the government and health organizations face in tackling Ebola in an area where years of instability has undermined locals’ confidence in the authorities.

The violence “will have a considerable impact on the whole response to Ebola,” a local public health official told Reuters on condition of anonymity.

“The general hospital which houses one of the Ebola treatment centers was the focus of angry protests this morning.

Ebola, Congo
Little 11-year-old German Umba, whose father died in May of Ebola and who is being monitored by the U.N. for potential signs of infection along with her 6-year-old brother, hides her face in her shirt, sobbing, outside her classroom in Mbandaka, Congo. VOA

This is a normal reaction for a community that is bereaved for the umpteenth time,” the official said.

Also Read: Ebola Increases The Number of Orphans in DRC: UNICEF

The latest Ebola outbreak, which causes hemorrhagic fever, vomiting and diarrhea, is believed to have killed 99 people since July and infected another 48. (VOA)

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