Thursday March 21, 2019

An enzyme has been identified to stop Ebola infection

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An enzyme has been identified to stop Ebola infection
An enzyme has been identified to stop Ebola infection. wikimedia commons

London, Dec 30, 2017: Raising hope for an effective drug to treat people with Ebola virus, researchers have found that an enzyme could help prevent the deadly virus from spreading.

The enzyme takes away the virus’ ability to copy itself and thus produce more virus particles and more infection, said the study published in the journal Molecular Cell.

‘When the Ebola virus enters the human cell, its only purpose is to copy itself, fast. First it must copy all its proteins, then its genetic material,” said Jakob Nilsson, Professor at University of Copenhagen in Denmark.

“But by inhibiting a specific enzyme we rob the Ebola virus of its ability to copy itself. And that may potentially prevent an Ebola infection from spreading,” Nilsson said.

There is currently no available treatment for Ebola virus infection.

However, the researchers behind the new study found what is called a new host factor for Ebola virus.

It can be described as a small part of the host’s — for example the human body’s — own cells, which the Ebola virus uses to copy itself and produce more infection.

The virus uses the host factor enzyme PP2A-B56 to start producing proteins.

So when PP2A-B56 is switched off, the virus’ ability to copy itself and produce more infection is stopped.

“When we inhibit the PP2A-B56 enzyme, we remove the first link in a long process, which ends with Ebola spreading. And we can tell that it works,” Nilsson said.

“The Ebola infection in cell cultures where we have inhibited the PP2A-B56 enzyme is 10 times smaller after 24 hours compared to infections where we have not inhibited this enzyme,” Nilsson added.

But because the researchers have so far focused on cell cultures, there is still work to be done before their results can be used to treat people infected with Ebola.

Initially the researchers hope to be able to test it on animals and, in the long term, develop a drug that inhibits the relevant enzyme. (IANS)

Next Story

Ebola Epidemic To Spread in Eastern DRC, Claims WHO

The Ebola outbreak in North Kivu and Ituri provinces is the second largest in history after the 2014 epidemic in West Africa that killed more than 11,000 people.Prior to the recent incidents, progress was being made in containing the spread of the Ebola virus in the DRC.

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Ebola
A health worker in a protective suit walks past burned structures after attackers set fire to an Ebola treatment center run by Medecins Sans Frontieres (MSF) in the east Congolese town of Katwa, Democratic Republic of Congo, Feb. 25, 2019. (Meinie Nicolai/MSF) VOA

The World Health Organization (WHO) says the deadly Ebola virus is likely to spread in the eastern Democratic Republic of Congo because of deteriorating security in conflict-ridden North Kivu and Ituri provinces.

The latest WHO figures put the number of Ebola cases at 885, including 555 deaths.

International efforts to stop the spread of the deadly Ebola virus in eastern DR Congo have hit a serious roadblock. The charity Doctors Without Borders has suspended its life-saving operations. The action follows attacks on two of its Ebola treatment centers this week — the first on February 24 in Katwa, followed by an attack three days later in Butembo.

Burned structures are seen after attackers set fire to an Ebola treatment center run by Medecins Sans Frontieres (MSF) in the east Congolese town of Katwa, Democratic Republic of Congo, Feb. 25, 2019. Picture taken February 25, 2019. (Laurie Bonnaud/MSF)
Burned structures are seen after attackers set fire to an Ebola treatment center run by Medecins Sans Frontieres (MSF) in the east Congolese town of Katwa, Democratic Republic of Congo, Feb. 25, 2019. Picture taken February 25, 2019. (Laurie Bonnaud/MSF) VOA

The World Health Organization called the attacks deplorable and said there is a great risk of the spread of the disease. During the attack on the facility in Butembo, four Ebola patients fled for their lives.

WHO spokesman Christian Lindmeier said three of the patients have since returned, while one is still missing.

“If you want, the positive note is that all of these four patients were convalescent, that means they were already getting better,” he said. “Hence, they had a lower viral load, which makes it way less likely for further infections.But yes, it is highly important to find those people, that last patient and then, of course, immediately start the contact tracing and monitor the contacts these patients might have been in touch with.”

Ebola
International efforts to stop the spread of the deadly Ebola virus in eastern DR Congo have hit a serious roadblock. VOA

Lindmeier said the WHO remains committed to staying in the DRC until the job is done. However, he notes that an Ebola outbreak as complex as this one can only be managed collectively and by having all the partners on the ground. He added that it is normal to expect organizations to do whatever is necessary to protect their staffs.

Also Read: India Should Crack Down Upon The Terror Sympathizers Within The Country

The Ebola outbreak in North Kivu and Ituri provinces is the second largest in history after the 2014 epidemic in West Africa that killed more than 11,000 people.Prior to the recent incidents, progress was being made in containing the spread of the Ebola virus in the DRC.

The WHO reports the disease is now largely under control in the former hot spots of Mangina, Beni, and Komanda.It says more than 250 people have been cured and 80,000 protected through vaccination. (VOA)