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Enzyme Nuak1 likely to help prevent Alzheimer’s Disease, say Researchers

Enzyme Nuak1 is going to prevent accumulation of toxic molecules in the brain

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A lady suffering from Alzheimer's. Flickr
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New York, October 23, 2016: Enzyme Nuak1 is a reliable potential target which can be used in drugs to prevent diseases such as Alzheimer’s, finds a research.

Enzyme Nuak1 helps to prevent accumulation of toxic molecules in the brain.

The study, published in Cell Press journal Neuron, took a three-pronged approach to help subdue early events that occur in the brain long before symptoms of Alzheimer’s disease are evident.

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The scientists were able to prevent those early events and the subsequent development of brain pathology in experimental animal models in the lab.

“Common diseases like Parkinson’s, Alzheimer’s and dementia are caused in part by abnormal accumulation of certain proteins in the brain,” said Huda Zoghbi, Professor at the Baylor College of Medicine, US.

Some proteins become toxic when they accumulate; they make the brain vulnerable to degeneration. Tau is one of those proteins involved in Alzheimer’s disease and dementia, suggested the study.

“Scientists in the field have been focusing mostly on the final stages of Alzheimer’s disease. Here we tried to find clues about what is happening at the very early stages of the illness, before clinical irreversible symptoms appear,” said Cristian Lasagna-Reeves, researcher at the Baylor College of Medicine.

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The scientists reasoned that if they could find ways to prevent or reduce Tau accumulation in the brain, they would uncover new possibilities for developing drug treatments for these diseases.

To find which enzymes affect Tau accumulation, the scientists systematically inhibited enzymes called Kinases.

“We inhibited about 600 Kinases one by one and found one, called Nuak1, whose inhibition resulted in reduced levels of Tau,” Zoghbi added.

The scientists screened the enzymes in two different systems, cultured human cells and the laboratory fruit fly. Screening in the fruit fly allowed the scientists to assess the effects of inhibiting the enzymes in a functional nervous system in a living organism.

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“We found one enzyme, Nuak1, whose inhibition consistently resulted in lower levels of Tau in both human cells and fruit flies. Then we took this result to a mouse model of Alzheimer’s disease and hoped that the results would hold, and they did. Inhibiting Nuak1 improved the behaviour of the mice and prevented brain degeneration,” Zoghbi added.

Confirming in three independent systems – human cells, the fruit fly and the mouse – that Nuak1 inhibition results in reduced levels of Tau and prevents brain abnormalities induced by toxic accumulation. (IANS)

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  • Antara

    A ray of hope!

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FIFA World Cup 2018: Indian Cuisine becomes the most sought after in Moscow

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Indian cuisine in FIFA World cup
Indian dishes available in Moscow during FIFA World Cup 2018, representational image, wikimedia commons

June 17, 2018:

Restaurateurs Prodyut and Sumana Mukherjee have not only brought Indian cuisine to the ongoing FIFA World Cup 2018 here but also plan to dish out free dinner to countrymen if Argentina wins the trophy on July 15.

Based in Moscow for the last 27 years, Prodyut and Sumana run two Indian eateries, “Talk Of The Town” and “Fusion Plaza”.

You may like to read more on Indian cuisine: Indian ‘masala’, among other condiments spicing up global food palate.

Both restaurants serve popular Indian dishes like butter chicken, kebabs and a varied vegetarian spread.

During the ongoing FIFA World Cup 2018, there will be 25 per cent discount for those who will possess a Fan ID (required to watch World Cup games).

There will also be gifts and contests on offers during matches in both the restaurants to celebrate the event.

The Mukherjees, hailing from Kolkata, are die-hard fans of Argentina. Despite Albiceleste drawing 1-1 with Iceland in their group opener with Lionel Messi failing to sparkle, they believe Jorge Sampaoli’s team can go the distance.

“I am an Argentina fan. I have booked tickets for a quarterfinal match, a semifinal and of course the final. If Argentina goes on to lift

During the World Cup, there will be 25 per cent discount for those who will possess a Fan ID (required to watch World Cup games).

There will also be gifts and contests on offers during matches in both the restaurants to celebrate the event.

FIFA World Cup 2018 Russia
FIFA World Cup 2018, Wikimedia Commons.

“We have been waiting for this World Cup. Indians come in large numbers during the World Cup and we wanted these eateries to be a melting point,” he added.

According to Cutting Edge Events, FIFA’s official sales agency in India for the 2018 World Cup, India is amongst the top 10 countries in terms of number of match tickets bought.

Read more about Indian cuisine abroad: Hindoostane Coffee House: London’s First Indian Restaurant.

Prodyut came to Moscow to study engineering and later started working for a pharmaceutical company here before trying his hand in business. Besides running the two restaurants with the help of his wife, he was into the distribution of pharmaceutical products.

“After Russia won the first match of the World Cup, the footfall has gone up considerably. The Indians are also flooding in after the 6-9 p.m. game. That is the time both my restaurants remain full,” Prodyut said.

There are also plans to rope in registered fan clubs of Latin American countries, who will throng the restaurants during matches and then follow it up with after-game parties till the wee hours.

“I did get in touch with some of the fan clubs I had prior idea about. They agreed to come over and celebrate the games at our joints. Those will be gala nights when both eateries will remain open all night for them to enjoy,” Prodyut said.

Watching the World Cup is a dream come true for the couple, Sumana said.

“We want to make the Indians who have come here to witness the spectacle and feel at home too. We always extend a helping hand and since we are from West Bengal, we make special dishes for those who come from Bengal,” she added. (IANS)