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Cancer Ribbon. Pixabay

A new research has set the stage for clinicians to potentially use levels of a pancreatic cancer patient’s PHLPP1 and PKC enzymes as a prognostic and for researchers to develop new therapeutic drugs that change the balance of the two enzymes as a means to treat the disease.

The study, published on Wednesday in Molecular Cell, was led by Alexandra Newton, professor in the Department of Pharmacology at the University of California, San Diego, School of Medicine, and Timothy Baffi, a graduate student in her lab, Xinhua news agency reported.


The new study built on the team’s work in 2015 that found the enzyme PKC, which was believed in previous studies to promote tumour growth, actually suppressed it.

The latest study took the investigation a step further by uncovering how cells regulate PKC activity and discovered that any time an over-active PKC is inadvertently produced, the PHLPP1 “proofreader” tags it for destruction.


Cancer patient.

“That means the amount of PHLPP1 in your cells determines your amount of PKC,” Newton said. “And it turns out those enzyme levels are especially important in pancreatic cancer.”

The team observed 105 pancreatic cancer tumours to analyze the enzyme levels in each one. About 50 per cent of patients with low PHLPP1/high PKC lived longer than five-and-a-half years.

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While still in the earliest stages, Newton hoped this information might one day aid pancreatic diagnostics and treatment.

Pancreatic cancer is caused by the abnormal and uncontrolled growth of cells in the pancreas, a large gland in the digestive system. It typically doesn’t show symptoms in the early stages. Sufferers tend to develop signs, such as back pain and jaundice, when it has spread to other organs. (IANS)


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This photo provided by the U.S. Attorney's Office for Utah shows fentanyl-laced fake oxycodone pills collected during an investigation

WASHINGTON — U.S. federal law enforcement agencies and Europol announced dozens of arrests to break up a global operation that sold illegal drugs using a shadowy realm of the internet.

At a Department of Justice news conference Tuesday in Washington, officials said they arrested 150 people for allegedly selling illicit drugs, including fake prescription opioids and cocaine, over the so-called darknet. Those charged are alleged to have carried out tens of thousands of illegal sales using a part of the internet that is accessible only by using specialized anonymity tools.

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Photo by Benjamin Dada on Unsplash

Currently, when users set up WhatsApp Pay in India, the service only verifies the phone number linked to your bank account to enable UPI-based transactions

Facebook-owned WhatsApp may soon ask users to verify their identity to make payments on the platform. According to XDA Developers, new strings spotted in the latest WhatsApp beta release suggest that the messenger will require users to upload verification documents to continue using payments on WhatsApp. Currently, when users set up WhatsApp Pay in India, the service only verifies the phone number linked to your bank account to enable UPI-based transactions. In Brazil, the messenger uses Facebook Pay to validate users' credit or debit cards to facilitate payments.

At the moment, the service doesn't require users to submit any identity verification documents to make payments. However, that might change soon, the report said. WhatsApp v2.21.22.6 beta includes a few new strings which suggest that users might have to submit identity verification documents to continue using payments.

The identity verification might be limited to those who use WhatsApp Pay to receive payments for their businesses. UPI-based apps, like Google Pay, PhonePe and even WhatsApp Pay don't require users to submit any documents to transfer or receive money. However, wallet apps like PayTM do ask for KYC verification as per RBI guidelines.

WhatsApp is yet to make an official announcement regarding this change. Since the new strings have just made their way to the beta version, it might be a while before the company reveals any details, the report said. (IANS/ MBI)


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Photo by Chelson Tamares on Unsplash

Practising good nail hygiene involves following a systematic process to ensure the longevity of our nail health.

By Rajesh U. Pandya

Although the world is recovering from coronavirus pandemic, we must not lower our guards and stay alert when it comes to hand hygiene to curb the spread of the deadly virus. But are we paying sufficient attention to our nail hygiene? Our nails are the index of well-being for our entire body. The manifestations of several critical diseases were first detected within the dirty nails.

The ignorance towards our nails becomes the breeding ground of harmful bacteria. These germs enter our body through our hands because in India we eat through our bare hands. Therefore, nail hygiene is crucial and without it hand hygiene is incomplete.

Practising good nail hygiene involves following a systematic process to ensure the longevity of our nail health. It includes ensuring that food particles, dirt and dust are not sticking to our nails and there is no build-up of nail bacteria. Thankfully, contrary to popular belief, it is not that difficult to maintain good nail hygiene. A little diligence, awareness and attention are sufficient to keep our nails healthy.

Avoiding nail hygiene makes you prone to viral infections
Due to constant negligence towards the cleanliness of the nails, many serious issues like bacterial and viral infections arise. Often these lead to serious health problems. Our hand hygiene is not perfect till the time we clean the undersides of our nails besides washing hands regularly. Most people don't mind sharing nail clippers with others. This is however an extremely unhygienic practice. When we don't share any of our personal hygiene products then why do we share our nail clippers? Nails harbour abundant germs, bacteria and viruses and sharing nail clippers is equivalent to exchanging those microorganisms.

microscopic organisms Nails harbour abundant germs, bacteria and viruses and sharing nail clippers is equivalent to exchanging those microorganisms.| Photo by CDC on Unsplash

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