Saturday August 24, 2019

‘Epilepsy drug during pregnancy ups the oral cleft risk in babies’

The findings are based on data on more than one million live births over a period of 10 years in the US.

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Low doses of topiramate may also increase the risk of oral clefts but to a lesser extent. Wikimedia Commons
Low doses of topiramate may also increase the risk of oral clefts but to a lesser extent. Wikimedia Commons

The study, published in the journal Neurology, said the risk is particularly high when the drug is used in high doses. “Our results suggest that the increased risk of oral clefts is most pronounced in women taking higher doses of topiramate to treat epilepsy,” said study co-author Elisabetta Patorno of Brigham and Women’s Hospital in Boston, US.

“Low doses of topiramate may also increase the risk of oral clefts but to a lesser extent,” Patorno said. “We hope that this work gives important information to women and their clinicians as they determine the best course of treatment and options available to individuals,” Patorno added. The findings are based on data on more than one million live births over a period of 10 years in the US.

Epilepsy is likely due to the higher doses of topiramate when used for controlling seizures. Wikimedia Commons
Epilepsy is likely due to the higher doses of topiramate when used for controlling seizures. Wikimedia Commons

The team examined the risk of oral clefts including cleft palate or cleft lip among three groups infants born to women who had taken topiramate in their first trimester; infants born to women who had taken the drug lamotrigine (an unrelated drug used to treat bipolar disorder and epilepsy); and infants who had not been exposed to anti-epileptic medications in utero.

The researchers found that the risk of oral clefts was approximately three times higher for the topiramate group than for either the lamotrigine or the unexposed group.

“Our results suggest that women with epilepsy on topiramate have the highest relative risk of giving birth to a baby with cleft lip or cleft palate, likely due to the higher doses of topiramate when used for controlling seizures,” said corresponding author Sonia Hernandez-Diaz of the Harvard T.H. Chan School of Public Health. “The best course may be to avoid prescribing high doses of topiramate to women of childbearing age unless the benefits clearly outweigh the risks,” she added. IANS

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U.S. Regulators Approve New Tuberculosis Drug that Shows Dramatic Results

The new drug, Pretomanid, was developed by the nonprofit TB Alliance

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FILE - A tuberculosis patient receives treatment at a clinic in Jakarta, Indonesia. VOA

U.S. regulators Wednesday approved a new tuberculosis drug that when taken with two other medicines shows dramatic results.

The new drug, Pretomanid, was developed by the nonprofit TB Alliance.

A study shows that when taken with taken with two other drugs. Pretomanid cured 90% of patients suffering from a strain of TB that is resistant to other treatments.

The study shows the three-drug cocktail can cure TB in about six months and can also stop patients from spreading the disease in just a few days.

US, Tuberculosis, Drug
U.S. regulators Wednesday approved a new tuberculosis drug that when taken with two other medicines shows dramatic results. Pixabay

Most current TB treatments require patients to take multiple numbers of pills and months of very painful daily shots. This treatment of pills and shots can last as long as two years. Doctors say many patients either give up first or die.

Also Read- The Effectiveness of Gong Conversation Intelligence

Tuberculosis generally attacks the lungs and is spread when someone with the infection sneezes or coughs. It kills about 1.6 million people every year worldwide. (VOA)