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Epilepsy drug in pregnant women may increase oral cleft risk in baby. wikimedia commons

New Delhi, Dec 29, 2017: The study, published in the journal Neurology, said the risk is particularly high when the drug is used in high doses. “Our results suggest that the increased risk of oral clefts is most pronounced in women taking higher doses of topiramate to treat epilepsy,” said study co-author Elisabetta Patorno of Brigham and Women’s Hospital in Boston, US.

“Low doses of topiramate may also increase the risk of oral clefts but to a lesser extent,” Patorno said. “We hope that this work gives important information to women and their clinicians as they determine the best course of treatment and options available to individuals,” Patorno added. The findings are based on data on more than one million live births over a period of 10 years in the US.


The team examined the risk of oral clefts including cleft palate or cleft lip among three groups infants born to women who had taken topiramate in their first trimester; infants born to women who had taken the drug lamotrigine (an unrelated drug used to treat bipolar disorder and epilepsy); and infants who had not been exposed to anti-epileptic medications in utero.

The researchers found that the risk of oral clefts was approximately three times higher for the topiramate group than for either the lamotrigine or the unexposed group. “Our results suggest that women with epilepsy on topiramate have the highest relative risk of giving birth to a baby with cleft lip or cleft palate, likely due to the higher doses of topiramate when used for controlling seizures,” said corresponding author Sonia Hernandez-Diaz of the Harvard T.H. Chan School of Public Health. “The best course may be to avoid prescribing high doses of topiramate to women of childbearing age unless the benefits clearly outweigh the risks,” she added. (IANS)


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Photo by Wikimedia Commons

Japan launched its new satellite, QZS-1R.

Japan has successfully launched a new navigation satellite into orbit that will replace its decade-old navigation satellite.

The satellite, QZS-1R, was launched onboard an H-2A rocket that lifted off from the Tanegashima Space Center at 10.19 p.m. on Monday night, Mitsubishi Heavy Industries said in a statement.

The company builds and operates H-2A rockets the Japan Aerospace Exploration Agency (JAXA).

QZS-1R is a replacement for Quasi-Zenith Satellite System 1 satellite first launched in 2010. “It was a really beautiful launch," the company said in a tweet after a successful lift-off.

"H-IIA F44 flight proceeded nominally. Approximately 28 minutes 6 seconds after launch, as planned, the payload separated from the launch vehicle," the statement said.

The official QZSS website lists four satellites in the constellation: QZS-1, QZS-2, QZS-3 and QZS-4, Space.com reported.

The QZSS constellation will eventually consist of a total of seven satellites that fly in an orbit passing through a near-zenith (or directly overhead) above Japan, and QZS-R1 is meant to share nearly the same transmission signals as recent GPS satellites, according to JAXA.

It is specially optimised for mountainous and urban regions in Japan, JAXA said.

Mitsubishi's H-2A 202 rocket launch system has been operational since 2003 and has sent satellites to locations such as Venus (Akatsuki) and Mars (Emirates Mars Mission).

The latest H2-A rocket launch is the first since November 29, 2020, when Japan launched an advanced relay satellite with laser communications tech into orbit, the report said. (IANS/JB)


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Photo by Mike Enerio on Unsplash

Fireworks light up the night sky

Everyone loves firecrackers, even the most environment-friendly advocates cannot hide their joy when they see these delightful lights colour the skies. India celebrates Diwali in the true spirit of her culture and heritage by spraying the navy-blue skies with sparkling hues of gold, silver, red, and green. Firecrackers are not just a tradition in this country, they are a legacy.

The original connotation one makes with fireworks in China. The elaborate Chinese celebrations with dragons and zapping firecrackers have left their mark in human memory, but the use of fireworks is not limited to heralding the Chinese New Year. All over the world, fireworks have come to symbolise the ultimate celebration. During Diwali in India, this spirit is re-ignited every year.

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VOA

A visitor looks at statues of the 'Royal treasures of Abomey kingdom' on display at the Musee du quai Branly in Paris on Sept. 10, 2021, part of 26 artworks set to be restituted to Benin later in the year.

PARIS — In a decision with potential ramifications across European museums, France is displaying 26 looted colonial-era artifacts for one last time before returning them home to Benin.

The wooden anthropomorphic statues, royal thrones and sacred altars were pilfered by the French army in the 19th century from Western Africa.

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