Monday January 21, 2019

Here’s How Exercise Can Help Breast Cancer Survivors

Among those who completed the program, those who received the lifestyle intervention were about 50 per cent more likely to have disease-free survival than those who received the general recommendations

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How exercise can help breast cancer survivors. Pixabay

Survivors of early-stage breast cancer who exercise and eat a healthy diet are more likely to lose weight and experience higher rates of disease-free survival, a new study suggests.

The research is based on an examination of a lifestyle intervention that included exercise, diet, and at least one other component such as counselling, stress management, and discontinuing tobacco smoking.

The study showed that obesity and low physical activity are associated with higher risks of developing breast cancer, as well as an increased risk of recurrence and reduced survival.

“Lifestyle intervention might improve the prognosis of breast cancer patients if adherence is high,” said Wolfgang Janni from the University of Ulm in Germany.

“Many breast cancer survivors would like to contribute actively to improving their prognosis, and guiding them on lifestyle factors that can help them control weight is one possible way to positively impact patient outcomes,” said Janni.

For the study, the researchers enrolled 2,292 women among which all had a body mass index of 24 or higher.

Cancer
Cancer Ribbon. Pixabay

Some women were randomly assigned to receive either telephone-based lifestyle intervention for two years while others received general recommendations for a healthy lifestyle alone.

Those who received the telephone calls were given advice on how to improve their diets, lower fat intake, increase physical activity, achieve moderate weight loss and other tips that were geared to their specific needs.

Findings, presented at the 2018 San Antonio Breast Cancer Symposium in the US, demonstrated that patients in the lifestyle intervention arm had lost an average of one kg, while the patients in the control group had gained an average of 0.95 kg.

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Overall, 1,477 patients completed the lifestyle intervention. Those who completed the program had a 35 per cent higher rate of disease-free survival than those who began the program but did not complete it.

Among those who completed the program, those who received the lifestyle intervention were about 50 per cent more likely to have disease-free survival than those who received the general recommendations. (IANS)

Next Story

Drugs of Breast Cancer Useful in Treating Drug-Resistant Lung Tumours

For the study, the researchers targeted a specific interaction between the RAS protein and p110a

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What is to be blamed for childhood cancer? Find it out here. Pixabay

A class of drugs used to treat certain breast cancer could help tackle lung cancers that have become resistant to targeted therapies, suggests a study done on mice.

The study showed that lung tumours in mice caused by mutations in a gene called EGFR shrunk significantly when a protein called p110a was blocked by the drugs.

“At the moment, patients with EGFR-mutant lung cancers are given targeted treatments that are very effective for the first few years,” said lead researcher Julian Downward, Associate Research Director of the Francis Crick Institute in the UK.

“These drugs are improving, but unfortunately after a couple of years, cancer usually becomes resistant and starts to grow and spread again. The second line of treatment is currently conventional chemotherapy, which is not targeted and has substantial side-effects,” said Downward.

Importantly, it would be worth investigating whether p110a inhibitors could be used as second-line therapy.

Cancer
Cancer Ribbon. Pixabay

Findings, published in Cell Reports, showed that when they blocked this interaction in genetically modified mice with EGFR mutations, their tumours shrank significantly to about a tenth of the space inside the lung.

Before the intervention, the tumours filled around two-thirds of the space inside the lung.

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These drugs could potentially benefit patients with EGFR-mutant lung cancers whose tumours have become resistant to treatment and could be approved for clinical purposes in the near future, the team suggested.

Since the research is at such an early stage, more research in mice and patient cells would be needed, Downward noted. (IANS)