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Extract from a medicinal plant Anthocephalus Cadamba in combination with a dye exposed to near infra-red light can selectively kill cancer cells, found a multi-institutional study.
The synergistic activation of Reactive Oxygen Species (ROS) mediated autophagy (natural process of removing damaged cells) by light triggered nanoliposomes can be a useful strategy for enhancing the anti-cancer potential of combinational therapies, says the study led by researchers from the Indian Institute of Technology (IIT), Hyderabad.
The study involves Department of Biomedical Engineering, IIT, Hyderabad, Department of Biotechnology and Bioinformatics, University of Hyderabad, Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay and Division of Molecular Medicine, Bose Institute, Kolkata.
“We have taken organic solvent mediator extract from plant Anthocephalus Cadamba and then tested this extract on various cell lines, both normal healthy cell lines and cancer cell lines. We found that this extract from this plant is very selective in killing cancer cells,” Aravind Kumar Rengan from the Department of Biomedical Engineering at IIT Hyderabad, told IANS.
The researchers also found that this extract is highly hydrophobic. “We had to prepare a nano formulation out of it which will help in cells to uptake this extract easily. We prepared that, tested and found that this is very selective in killing cancer cells.”
The researchers did High Performance Liquid Chromatography (HPLC) and found few components, two of them not reported earlier.
They had to then carry out a process to help release the extract from nano formulation. “For this we deployed photothermal effect in the sense we have added a dye to this nano formulation apart from the extract and this dye will respond to only near-infrared light. When we trigger this nano-formulation using this light, the dye inside nano-formulation absorbs this light, converts it into heat and that heat is going to destabilize the nano-formaulation which will in turn cause release of this extract.”
The team carried out some basic in-vitro analysis with cell lines in lab-level conditions. It then performed a pilot study in mouse model. “We need to have a thorough in-vitro as well as animal studies to go towards translations,” he said.
Stating that the team will carry on further analysis, he said they need to identify what all those particular contents in that extract which are causing selective cancer cell death. “Only then it will be easy to go for large-scale production of that particular extract.”Rengan said a lot of clinical trials would be needed and this will take significant amount of time.
“There are many compounds which show very good results in in-vitro and animal studies but they fail in clinical trials. Unless and until we test and do stage-I clinical trials we are not very sure how effective it will be in human system. Only good thing we don’t use harmful chemicals we use only plant extract which is very much compatible.” (IANS)
The Mysore kingdom became a popular tourist destination after India became an independent country. The Wodeyar dynasty who succeeded Tipu Sultan are still royalty, but they do not rule the state. Their heritage and culture have become what Karnataka is famous for.
Among the many things that Mysore offers to the state of Karnataka, the Mysore Peta is one. In north India, various cultures have their own headgears. They wear their traditional outfits on the days of festivities and ceremonies. Likewise, in the south, especially in Karnataka, the Mysore Peta is worn.
Made of the traditional Mysore silk, the Peta is usually a white turban decorated with a gold silk thread. It is worn by the Maharaja of Mysore during Dasara, or any other public appearance. This tradition has been preserved and is used all over the state by prominent leaders.
Politicians who want to appease older, more experienced politicians, offer a peta as a sign of honour. International guests are welcomed into the city with a peta and silk shawl. In universities, the peta is worn as a replacement to the black caps, as a sign of graduation and scholarship.
Even today, in the court of Mysore, petas are worn and given out as tokens of honour. The peta of the king varies from the ones a courtier wears, and even among them, there is a difference according to status. Petas are made by a particular family and passed down from generation to generation.
Keywords: Mysore kingdom, peta, silk, Wodeyar
Renowned feminist activist, author, and a face of the women's rights movement in India, Kamla Bhasin, passed away today morning at the age of 74.
The news of the same was shared by activist Kavita Srivastava on Twitter. The tweet said, "Kamla Bhasin, our dear friend, passed away around 3am today 25th Sept. This is a big setback for the women's movement in India and the South Asian region. She celebrated life whatever the adversity. Kamla you will always live in our hearts. In Sisterhood, which is in deep grief."
Bhasin, since the 1970s, has been an advocate of women's movement not just in India but other South Asian countries as well. In fact, in 2002, she founded a feminist network named as 'Sangat', which only motive was to work with underprivileged women from rural and tribal communities, often by using non-literary tools like plays, songs, and art.
Having a Master's degree in literature, Bhasin has written many books on gender theory and feminism, and interestingly, many of them have been translated into more than 30 languages. Another quick fact revolving around Bhasin is that the chant of 'Azadi', which is often heard at protests and rallies, was first popularised by her as feminist slogan against patriarchy.
Bhasin was awarded with the "Laadli Life Time Achievement Award" in the year 2017 for her commendable work.
Keywords: Kamla Bhasin, Feminism, India, Patriarchy, Literature, Feminist, Women, Rights
The 76th United Nations General Assembly session opened discussion on 14th September. The high-level General debate began on 21st September and it will continue till 27th September. The agenda of this year's UNGA session is 'Building Resilience through hope to recover from COVID-19, rebuild sustainably, respond to the needs of the planet, respect the rights of people, and revitalize the United Nations'. Only 109 heads of state and government will attend the session in person and approximately 60 other speakers will address the debate via pre-recorded video statements due to the ongoing pandemic.
PM Narendra Modi is the first world leader who has been scheduled to address the General Assembly. He landed in New York at 6:00 AM (IST). "Landed in New York City. Will be addressing the UNGA at 6:30 PM (IST) on the 25th," he tweeted. He was received at the airport by India's permanent representative to the UN ambassador Mr. T S Tirumurti and ambassador of India to the USA Mr. Taranjit Singh Sandhu.
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Before leaving for US PM Modi said, "I will be visiting the USA from 22-25 September 2021 at the invitation of His Excellency President Joe Biden of the United States of America. During my visit, I will review the India-US Comprehensive Global Strategic Partnership with President Biden and exchange views on regional and global issues of mutual interest".
During his 5-day visit to the US PM Modi held his first bilateral meeting with President Joe Biden in the oval office of the white house. It was their first in-person meet-up after meeting on virtual mode on three different occasions. He also held a meeting with US Vice President Kamala Harris joined by the Prime Minister of Australia Scott Morrison and Prime Minister of Japan Yoshihide Suga. He held one on one meeting with the CEOs of some top companies like Qualcomm, Adobe, First Solar, General Atomics, and Blackstone. PM Modi participated in the Quad Summit held on Friday, in which the fight against Covid, climate change counterterrorism, along free and open Indo-Pacific, were the key concerns of the discussion. He also took part in Covid-19 Global Summit hosted by US President Joe Biden. Pakistan's role in terrorism was also heavily discussed
PM held a meeting with US Vice President Kamala Harris joined by the Prime Minister of Australia and Japan. Twitter
Today, 25th September 2021 PM Narendra Modi will address the 76th UNGA session at 6:30 PM (IST) which will be live-streamed on various social media platforms like Twitter, Facebook, and YouTube. PM Modi will talk about issues concerning pressing global challenges which will include the COVID-19 pandemic, the need to combat terrorism, climate change, and other important issues. It was in 2019 when PM Modi addressed the UN General Assembly physically as the pandemic went global in 2020, the 75th UNGA was held online where the speakers pre-recorded their speeches. In 2021, the option to pre-record statements has been kept open for the world leaders as the pandemic is worsening in some countries.
Prime Minister Narendra Modi will fly back to India after addressing the United Nations General Assembly.