Wednesday October 16, 2019

Eye Drops Exhibit Potential for Treating Dry Eye Disease

Researchers demonstrates that patients with dry eye disease experience reduced signs and symptoms of the condition in response to a new Drops for Eyes treatment.

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Research has found new drops for Eyes treat dry eye disease by knocking the immune system out of this cycle. Pixabay

Researchers, found that Eye Drops have capability for treating dry eye disease. Scientists,including one of Indian-origin, have identified the presence of a specific type of antibody, called anti-citrullinated protein autoantibodies, or ACPAs, in human tear fluid.

They also demonstrated that patients with dry eye disease experienced reduced signs and symptoms of the condition in response to a new eye drop treatment — made from pooled human antibodies — that targets ACPAs, said the study published in the journal The Ocular Surface.

“The burden of autoimmune dry eye is much greater than just having an occasional feeling of dryness, it can severely compromise quality of life to the point of disability and can compromise a person’s vision,” said Indian-origin researcher and study’s author Sandeep Jain, Professor at the University of Illinois, Chicago.

In the study, the researchers identified ACPAs as another cause of eye inflammation that also contributes to the development of these webs, which Jain calls “a vicious cycle of inflammation”.

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During the research, 27 participants with severe dry eyes diseases participated in the trial. Pixabay

The new eye drops treat dry eye disease by knocking the immune system out of this cycle, at least partially.

The drops are formulated using pooled antibodies — which are made from immune globulins processed from the donated blood of thousands of individuals, all containing varied types of antibodies — that counteract the negative effects of ACPAs.

The phase I/II drug trial compared the antibody-based eye drops with eye drops without the antibodies.

During the study, 27 participants with severe dry eye disease participated in the trial.

The participants were randomised into two groups. One group was given eye drops made from pooled antibodies and instructed to administer one drop to each eye twice daily for eight weeks.

The control group was given the same instructions with eye drops made without antibodies.

The researchers evaluated patients’ symptoms through questionnaires and measured the extent of corneal damage and the amount of pro-inflammatory biomarkers on the surface of the eye before and for the duration of the study.

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Drops for Eyes containing pooled antibodies may be safe and effective for treating dry eye disease. Pixabay

They found that people using antibody-based eye drops had a statistically significant and clinically meaningful reduction in corneal damage at eight weeks compared with the control group.
In the test group, the amount of pro-inflammatory biomarkers — or dry areas — also was reduced on the surface of the eye.

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“The data from this early clinical trial suggests that eye drops containing pooled antibodies may be safe and effective for treating dry eye disease and we look forward to conducting larger randomised trials to definitively prove its efficacy,” Jain added. (IANS)

Next Story

Afghanistan Initiates Polio Drive, Targets 8.5mn Kids

The campaign is launched in most of the places in Afghanistan where limited children were reached earlier in the year

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Afghan health authorities on launched sub-national immunization campaign to give polio immunity vaccination dose to 8.5 million children under five years old. Pixabay

Afghan health authorities on Monday launched an extended sub-national immunization campaign to give polio immunity vaccination dose to 8.5 million children under five years old.

“The five-day campaign targets over 8.5 million children under 5 years of age in 324 districts across the country. The campaign is launched in most of the places where limited children were reached earlier in the year,” Xinhua news agency quoted the Ministry of Public Health as saying.

“We are concerned that following the long pause in polio vaccination in parts of the country, more children have become vulnerable to poliovirus, therefore it is of paramount importance that we vaccinate those who have been missing out,” it added.

The Ministry called on the parents to protect their children against polio by letting the vaccinators get in when they come knocking on the doors.

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The five-day campaign in Afghanistan targets over 8.5 million children against Polio under 5 years of age in 324 districts across the country. Pixabay

The ongoing insurgency and conflicts have been hindering the efforts to curb the infectious disease in the mountainous country as 1.2 million children from inaccessible areas have missed previous drives.

READ MORE: PM Modi Stooped Down to Lift Environmental Awareness

There are only two countries in the world, Pakistan and Afghanistan, where polio cases are still reported. (IANS)